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HAMAP rule MF_04035

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General rule information [?]

Accession MF_04035
Dates 30-AUG-2016 (Created)
29-SEP-2022 (Last updated, Version 4)
Viruses; Herpesviridae
Templates P04288 (GM_HHV11); P16733 (GM_HCMVA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Envelope glycoprotein M;
Gene name

Comments [?]

Function Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
Subunit Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.
Subcellular location Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Similarity Belongs to the herpesviridae glycoprotein M family.

Keywords [?]

Gene Ontology [?]

GO:0044175; Cellular component: host cell endosome membrane.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0044201; Cellular component: host cell nuclear inner membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.

Cross-references [?]

Pfam PF01528; Herpes_glycop; 1;

Computed features [?]

General Transmembrane; -; 8; trigger=yes;
ADD_TOPO_DOMAIN Intravirion; -; 5; trigger=yes;
Virion_surface; -; 4; trigger=yes;

Features [?]

From: GM_HHV11 (P04288)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     59     59       Interchain (with gN)     C  

Additional information [?]

Size range 344-473 amino acids
Related rules None
Fusion None