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HAMAP rule MF_04035

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General rule information [?]

Accession MF_04035
Dates 30-AUG-2016 (Created)
29-SEP-2022 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P04288 (GM_HHV11); P16733 (GM_HCMVA); [ Recover all ]
Triggered by HAMAP; MF_04035 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GM
Protein name RecName: Full=Envelope glycoprotein M;
Gene name Name=gM;

Comments [?]

FUNCTIONEnvelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
SUBUNITInteracts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.
SUBCELLULAR LOCATIONVirion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
SIMILARITYBelongs to the herpesviridae glycoprotein M family.

Keywords [?]

Gene Ontology [?]

GO:0044175; Cellular component:host cell endosome membrane
GO:0044178; Cellular component:host cell Golgi membrane
GO:0044201; Cellular component:host cell nuclear inner membrane
GO:0016020; Cellular component:membrane
GO:0019031; Cellular component:viral envelope
GO:0055036; Cellular component:virion membrane

Cross-references [?]

Pfam PF01528; Herpes_glycop; 1;
General Transmembrane; -; 8;
ADD_TOPO_DOMAIN Intravirion; -; 5;
ADD_TOPO_DOMAIN Virion_surface; -; 4;

Features [?]

From: GM_HHV11 (P04288)
Key From To Description Tag Condition FTGroup
DISULFID 59 59 /note="Interchain (with gN)" C

Additional information [?]

Size range 344-473 amino acids
Related rules None
Fusion Nter: None Cter: None

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