HAMAP rule MF_04035
General rule information
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Accession | MF_04035 |
Dates | 30-AUG-2016 (Created) 29-SEP-2022 (Last updated, Version 4) |
Name | HSV_GM |
Scope | Viruses; Herpesviridae |
Templates | P04288 (GM_HHV11); P16733 (GM_HCMVA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network. |
Subunit | Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex. |
Subcellular location | Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs. |
Similarity | Belongs to the herpesviridae glycoprotein M family. |
Keywords
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Disulfide bond
Glycoprotein
Host endosome
Host Golgi apparatus
Host membrane
Host nucleus
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Virion
Glycoprotein
Host endosome
Host Golgi apparatus
Host membrane
Host nucleus
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Virion
Gene Ontology
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GO:0044175; Cellular component: host cell endosome membrane.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0044201; Cellular component: host cell nuclear inner membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0044201; Cellular component: host cell nuclear inner membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 8; trigger=yes; |
ADD_TOPO_DOMAIN | Intravirion; -; 5; trigger=yes; |
Virion_surface; -; 4; trigger=yes; |
Features
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From: GM_HHV11 (P04288) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DISULFID | 59 | 59 | Interchain (with gN) | C |
Additional information
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Size range | 344-473 amino acids |
Related rules | None |
Fusion | None |