HAMAP rule MF_04035

Accession	MF_04035
Dates	30-AUG-2016 (Created) 29-SEP-2022 (Last updated, Version 4)

Name

HSV_GM

Scope

Viruses; Herpesviridae

Templates

P04288 (GM_HHV11); P16733 (GM_HCMVA): [Recover all]

Triggered by

HAMAP; MF_04035 (Get profile general information and statistics)

Identifier

GM

Protein name

RecName: Full=Envelope glycoprotein M; Short=gM;

Gene name

gM

Function	Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
Subunit	Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.
Subcellular location	Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Similarity	Belongs to the herpesviridae glycoprotein M family.

Disulfide bond
Glycoprotein
Host endosome
Host Golgi apparatus
Host membrane
Host nucleus
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Virion

GO:0044175; Cellular component: host cell endosome membrane.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0044201; Cellular component: host cell nuclear inner membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.

Pfam	PF01528; Herpes_glycop; 1;
PRINTS	PR00333; HSVINTEGRLMP; 1;

General	Transmembrane; -; 8; trigger=yes;
ADD_TOPO_DOMAIN	Intravirion; -; 5; trigger=yes;
	Virion_surface; -; 4; trigger=yes;

From: GM_HHV11 (P04288)

Key

From

To

Description

Tag

Condition

FTGroup

DISULFID

59

59

Interchain (with gN)

C

Size range	344-473 amino acids
Related rules	None
Fusion	None

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