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HAMAP rule MF_04037

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General rule information [?]

Accession MF_04037
Dates 15-SEP-2016 (Created)
29-SEP-2022 (Last updated, Version 7)
Scope(s) Viruses
Template(s) O09800 (GN_HHV11); P16795 (GN_HCMVA); P0C764 (GN_VZVO); [ Recover all ]
Triggered by HAMAP; MF_04037 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GN
Protein name RecName: Full=Envelope glycoprotein N;
Gene name Name=gN;

Comments [?]

FUNCTIONEnvelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis.
SUBUNITInteracts (via N-terminus) with gM (via N-terminus). The gM-gN heterodimer forms the gCII complex.
SUBCELLULAR LOCATIONVirion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
SIMILARITYBelongs to the herpesviridae glycoprotein N family.

Keywords [?]

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0019031; Cellular component:viral envelope
GO:0055036; Cellular component:virion membrane

Cross-references [?]

Pfam PF03554; Herpes_UL73; 1;
Pfam PF12522; UL73_N; 1;
Pfam PF05702; Herpes_UL49_5; 1;
PIRSF PIRSF038075; Herpes_UL49A_env; 1;
ADD_TOPO_DOMAIN Virion_surface; -; 1;
ADD_TOPO_DOMAIN Intravirion; -; 1;
General Transmembrane; -; 1;
General Signal; -; 0-1;

Features [?]

From: GN_HHV11 (O09800)
Key From To Description Tag Condition FTGroup
case not <Feature:Transmembrane==1>
TOPO_DOM Nter 55 /note="Virion surface"
TRANSMEM 56 76 /note="Helical"
TOPO_DOM 77 Cter /note="Intravirion"
end case
DISULFID 46 46 /note="Interchain (with gM)" C

Additional information [?]

Size range 84-171 amino acids
Related rules None
Fusion Nter: None Cter: None

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