HAMAP rule MF_04037

Accession	MF_04037
Dates	15-SEP-2016 (Created) 29-SEP-2022 (Last updated, Version 7)

Name

HSV_GN

Scope

Viruses; Herpesviridae

Templates

O09800 (GN_HHV11); P16795 (GN_HCMVA); P0C764 (GN_VZVO): [Recover all]

Triggered by

HAMAP; MF_04037 (Get profile general information and statistics)

Identifier

GN

Protein name

RecName: Full=Envelope glycoprotein N;

Gene name

gN

Function	Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis.
Subunit	Interacts (via N-terminus) with gM (via N-terminus). The gM-gN heterodimer forms the gCII complex.
Subcellular location	Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
Similarity	Belongs to the herpesviridae glycoprotein N family.

Disulfide bond
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Virion

GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.

Pfam	PF03554; Herpes_UL73; 1;
	PF12522; UL73_N; 1;
	PF05702; Herpes_UL49_5; 1;
PIRSF	PIRSF038075; Herpes_UL49A_env; 1;

ADD_TOPO_DOMAIN	Virion_surface; -; 1; trigger=yes;
	Intravirion; -; 1; trigger=yes;
General	Transmembrane; -; 1; trigger=yes;

General

Signal; -; 0-1; trigger=yes;

From: GN_HHV11 (O09800)

Key

From

To

Description

Tag

Condition

FTGroup

TOPO_DOM

Nter

55

Virion surface

TRANSMEM

56

76

Helical

TOPO_DOM

77

Cter

Intravirion

DISULFID

46

46

Interchain (with gM)

C

Size range	84-171 amino acids
Related rules	None
Fusion	None

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