HAMAP rule MF_04037
General rule information
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Accession | MF_04037 |
Dates | 15-SEP-2016 (Created) 29-SEP-2022 (Last updated, Version 7) |
Name | HSV_GN |
Scope | Viruses; Herpesviridae |
Templates | O09800 (GN_HHV11); P16795 (GN_HCMVA); P0C764 (GN_VZVO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis. |
Subunit | Interacts (via N-terminus) with gM (via N-terminus). The gM-gN heterodimer forms the gCII complex. |
Subcellular location | Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network. |
Similarity | Belongs to the herpesviridae glycoprotein N family. |
Keywords
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Disulfide bond
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Virion
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Virion
Gene Ontology
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GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
Cross-references
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Pfam | PF03554; Herpes_UL73; 1; |
PF12522; UL73_N; 1; | |
PF05702; Herpes_UL49_5; 1; | |
PIRSF | PIRSF038075; Herpes_UL49A_env; 1; |
Computed features
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case <Feature:Transmembrane==1>
ADD_TOPO_DOMAIN | Virion_surface; -; 1; trigger=yes; |
Intravirion; -; 1; trigger=yes; | |
General | Transmembrane; -; 1; trigger=yes; |
end case
General | Signal; -; 0-1; trigger=yes; |
Features
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case not <Feature:Transmembrane==1>
From: GN_HHV11 (O09800) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TOPO_DOM | Nter | 55 | Virion surface | |||||||||
TRANSMEM | 56 | 76 | Helical | |||||||||
TOPO_DOM | 77 | Cter | Intravirion |
end case
Additional information
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Size range | 84-171 amino acids |
Related rules | None |
Fusion | None |