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HAMAP rule MF_04037

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General rule information [?]

Accession MF_04037
Dates 15-SEP-2016 (Created)
29-SEP-2022 (Last updated, Version 7)
Viruses; Herpesviridae
Templates O09800 (GN_HHV11); P16795 (GN_HCMVA); P0C764 (GN_VZVO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Envelope glycoprotein N;
Gene name

Comments [?]

Function Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis.
Subunit Interacts (via N-terminus) with gM (via N-terminus). The gM-gN heterodimer forms the gCII complex.
Subcellular location Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
Similarity Belongs to the herpesviridae glycoprotein N family.

Keywords [?]

Gene Ontology [?]

GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.

Cross-references [?]

Pfam PF03554; Herpes_UL73; 1;
PF12522; UL73_N; 1;
PF05702; Herpes_UL49_5; 1;
PIRSF PIRSF038075; Herpes_UL49A_env; 1;

Computed features [?]

case <Feature:Transmembrane==1>
ADD_TOPO_DOMAIN Virion_surface; -; 1; trigger=yes;
Intravirion; -; 1; trigger=yes;
General Transmembrane; -; 1; trigger=yes;
end case
General Signal; -; 0-1; trigger=yes;

Features [?]

case not <Feature:Transmembrane==1>
From: GN_HHV11 (O09800)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     55       Virion surface        
TRANSMEM     56     76       Helical        
TOPO_DOM     77     Cter       Intravirion        
end case
DISULFID     46     46       Interchain (with gM)     C  

Additional information [?]

Size range 84-171 amino acids
Related rules None
Fusion None