HAMAP rule MF_04039

Accession	MF_04039
Dates	19-SEP-2016 (Created) 12-OCT-2022 (Last updated, Version 4)

Name

HSV_CEP2

Scope

Viruses; Herpesviridae

Template

P10200 (CEP2_HHV11)

Triggered by

HAMAP; MF_04039 (Get profile general information and statistics)

Identifier

CEP2

Protein name

RecName: Full=Cytoplasmic envelopment protein 2; AltName: Full=Tegument protein BGLF2;

Function	Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating. Activates the AP-1 pathway and enhances EBV reactivation and virus release. Inhibits type I IFN-induced TYK2, STAT1 and STAT3 phosphorylation, thereby impairing type I IFN signaling and counteracting the ability of IFN-alpha to suppress the reactivation of EBV. Recruits SHP1 phosphatase to dephosphorylate STAT1. Mediates STAT2 ubiquitination and proteasomal degradation. Also suppresses type II and type III IFN signaling. Contributes to G1/S arrest in the host cell. Acts as an miRNA regulator that interferes with the function of RISC in miRNA-mediated mRNA silencing. As a result, SUMOylation is increased. When encapsulated in the exosomes released by EBV-infected host cells, may facilitate the infection in recipient cells.
Subunit	Homodimer. Interacts with BBLF1. Interacts with with the capsid. Interacts with BKRF4 (via C-terminus); this interaction is important for infectious virion production. Interacts with host TYK2; this interaction participates to the inhibition of host type I IFN signaling. Interacts with host STAT1; this interaction leads to STAT1 dephosphorylation and inhibition. Interacts with host STAT2; this interaction leads to STAT2 degradation. Interacts with host CUL1; this interaction might facilitate CUL1 recruitment to STAT2, leading to ubiquitination and degradation of the latter. Interacts with host AGO2; this interaction participates to the host miRNA regulation leading to enhanced SUMOylation.
Induction	Expressed in the late phase of the viral replicative cycle.
Subcellular location	Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures. Associates with the capsid before the final envelopment. Recruited to the TGN via the interaction with BBLF1. Also found in the exosomes released by the host cell.

Function	Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.
Subunit	Interacts with cytoplasmic envelopment protein 3 and with the capsid.
Subcellular location	Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.

Similarity

Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.

Host cytoplasm
Host Golgi apparatus
Host nucleus
Late protein
Virion
Virion tegument

G1/S host cell cycle checkpoint dysregulation by virus
Inhibition of host STAT1 by virus
Inhibition of host TYK2 by virus
Inhibition of host STAT2 by virus

GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0019033; Cellular component: viral tegument.

Pfam	PF03044; Herpes_UL16; 1;

Size range	330-373 amino acids
Related rules	None
Fusion	None

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