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Annotation rule MF_04044
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General rule information [?]

Accession MF_04044
Dates 6-OCT-2016 (Created)
16-MAR-2021 (Last updated, Version 6)
Viruses; Herpesviridae
Templates P10220 (LTP_HHV11); P03186 (LTP_EBVB9): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Large tegument protein deneddylase;
EC 3.4.22.-;

Comments [?]

Function Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.
Catalytic activity Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=;
Subunit Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins. Interacts with inner tegument protein. Interacts with capsid vertex specific component CVC2. Interacts with the major capsid protein/MCP.
Subcellular location Virion tegument. Host cytoplasm. Host nucleus. Note=Tightly associated with the capsid.

Keywords [?]

Gene Ontology [?]

GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0019033; Cellular component: viral tegument.
GO:0004843; Molecular function: thiol-dependent deubiquitinase.
GO:0039648; Biological process: modulation by virus of host protein ubiquitination.

Cross-references [?]

PROSITE PS51521; HTUSP; 1; trigger=PRU00854;
Pfam PF04843; Herpes_teg_N; 1;
PF03586; Herpes_UL36; 1;

Features [?]

From: LTP_HHV11 (P10220)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     Nter     273       Deubiquitination activity        
REGION     579     609       Interaction with inner tegument protein        
ACT_SITE     65     65             C  
ACT_SITE     197     197             D  
ACT_SITE     199     199             H  

Additional information [?]

Size range 2059-3755 amino acids
Related rules None
Fusion None