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HAMAP rule MF_04044

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General rule information [?]

Accession MF_04044
Dates 6-OCT-2016 (Created)
9-FEB-2023 (Last updated, Version 8)
Scope(s) Viruses
Template(s) P10220 (LTP_HHV11); P03186 (LTP_EBVB9); [ Recover all ]
Triggered by HAMAP; MF_04044 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LTP
Protein name RecName: Full=Large tegument protein deneddylase;

Comments [?]

FUNCTIONLarge tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.
CATALYTIC ACTIVITY Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=;
SUBUNITInteracts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins. Interacts with inner tegument protein. Interacts with capsid vertex specific component CVC2. Interacts with the major capsid protein/MCP.
SUBCELLULAR LOCATIONVirion tegument. Host cytoplasm. Host nucleus. Note=Tightly associated with the capsid.

Keywords [?]

Gene Ontology [?]

GO:0030430; Cellular component:host cell cytoplasm
GO:0042025; Cellular component:host cell nucleus
GO:0019033; Cellular component:viral tegument
GO:0004843; Molecular function:cysteine-type deubiquitinase activity
GO:0039648; Biological process:modulation by symbiont of host protein ubiquitination

Cross-references [?]

Pfam PF04843; Herpes_teg_N; 1;
Pfam PF03586; Herpes_UL36; 1;

Features [?]

From: LTP_HHV11 (P10220)
Key From To Description Tag Condition FTGroup
REGION Nter 273 /note="Deubiquitination activity"
REGION 579 609 /note="Interaction with inner tegument protein"
ACT_SITE 65 65 C
ACT_SITE 197 197 D
ACT_SITE 199 199 H

Additional information [?]

Size range 2059-3755 amino acids
Related rules None
Fusion Nter: None Cter: None

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