HAMAP rule MF_04047

General rule information [?]

Accession	MF_04047
Dates	13-FEB-2017 (Created) 20-NOV-2019 (Last updated, Version 4)

Name

ADV_CAP3

Scope

Viruses; Adenoviridae

Template

P12537 (CAP3_ADE05)

Triggered by

HAMAP; MF_04047 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CAP3

Protein name

RecName:		Full=Pre-hexon-linking protein IIIa;
AltName:		Full=Capsid vertex-specific component IIIa;
		Short=CVSC;
AltName:		Full=Protein IIIa;
AltName:		Full=pIIIa;
Contains:
	RecName:		Full=Hexon-linking protein IIIa;

Comments [?]

Function	Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.
Subunit	Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.
Subcellular location	Virion. Host nucleus. Note=Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.
Induction	Expressed in the late phase of the viral replicative cycle.
Ptm	Cleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.
Miscellaneous	All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Similarity	Belongs to the adenoviridae hexon-linking protein IIIa family.

Keywords [?]

Capsid decoration protein
Capsid protein
Host nucleus
Late protein
Phosphoprotein
Viral genome packaging
Virion
Viral release from host cell

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0019028; Cellular component: viral capsid.
GO:0098021; Cellular component: viral capsid, decoration.

Cross-references [?]

Pfam	PF02455; Hex_IIIa; 1;

Features [?]

From: CAP3_ADE05 (P12537)

Key From To Description Tag Condition FTGroup

CHAIN Nter Cter Pre-hexon-linking protein IIIa

CHAIN Nter 570 Hexon-linking protein IIIa

PROPEP 571 Cter

REGION Nter 106 Peripentonal hexon-tethering domain

REGION 138 251 Binding to hexon-linking protein

SITE 570 571 Cleavage; by viral protease

MOD_RES 225 225 Phosphoserine; by host S

MOD_RES 274 274 Phosphothreonine; by host T

MOD_RES 310 310 Phosphoserine; by host S

MOD_RES 444 444 Phosphoserine; by host S

MOD_RES 449 449 Phosphoserine; by host S

MOD_RES 450 450 Phosphoserine; by host S

MOD_RES 452 452 Phosphoserine; by host S

MOD_RES 469 469 Phosphoserine; by host S

MOD_RES 473 473 Phosphoserine; by host S

MOD_RES 490 490 Phosphotyrosine; by host Y

MOD_RES 494 494 Phosphoserine; by host S

MOD_RES 515 515 Phosphoserine; by host S

Additional information [?]

Size range	494-615 amino acids
Related rules	None
Fusion	None

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