HAMAP logo

HAMAP rule MF_04047

Send feedback

General rule information [?]

Accession MF_04047
Dates 13-FEB-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P12537 (CAP3_ADE05); [ Recover all ]
Triggered by HAMAP; MF_04047 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CAP3
Protein name RecName: Full=Pre-hexon-linking protein IIIa;
AltName: Full=Capsid vertex-specific component IIIa;
AltName: Full=Protein IIIa;
AltName: Full=pIIIa;
RecName: Full=Hexon-linking protein IIIa;

Comments [?]

FUNCTIONStructural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.
SUBUNITInteracts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.
SUBCELLULAR LOCATIONVirion. Host nucleus. Note=Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.
INDUCTIONExpressed in the late phase of the viral replicative cycle.
PTMCleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.
MISCELLANEOUSAll late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
SIMILARITYBelongs to the adenoviridae hexon-linking protein IIIa family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0019028; Cellular component:viral capsid
GO:0098021; Cellular component:viral capsid, decoration

Cross-references [?]

Pfam PF02455; Hex_IIIa; 1;

Features [?]

From: CAP3_ADE05 (P12537)
Key From To Description Tag Condition FTGroup
CHAIN Nter Cter /note="Pre-hexon-linking protein IIIa"
CHAIN Nter 570 /note="Hexon-linking protein IIIa"
PROPEP 571 Cter
REGION Nter 106 /note="Peripentonal hexon-tethering domain"
REGION 138 251 /note="Binding to hexon-linking protein"
SITE 570 571 /note="Cleavage; by viral protease"
MOD_RES 225 225 /note="Phosphoserine; by host" S
MOD_RES 274 274 /note="Phosphothreonine; by host" T
MOD_RES 310 310 /note="Phosphoserine; by host" S
MOD_RES 444 444 /note="Phosphoserine; by host" S
MOD_RES 449 449 /note="Phosphoserine; by host" S
MOD_RES 450 450 /note="Phosphoserine; by host" S
MOD_RES 452 452 /note="Phosphoserine; by host" S
MOD_RES 469 469 /note="Phosphoserine; by host" S
MOD_RES 473 473 /note="Phosphoserine; by host" S
MOD_RES 490 490 /note="Phosphotyrosine; by host" Y
MOD_RES 494 494 /note="Phosphoserine; by host" S
MOD_RES 515 515 /note="Phosphoserine; by host" S

Additional information [?]

Size range 494-615 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)