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Annotation rule MF_04049
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General rule information [?]

Accession MF_04049
Dates 6-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 3)
Name ADV_CAP8
Scope
Viruses; Adenoviridae
Template P24936 (CAP8_ADE05)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CAP8
Protein name
RecName: Full=Pre-hexon-linking protein VIII;
AltName: Full=Pre-protein VIII;
Short=pVIII;
Contains:
RecName: Full=Hexon-linking protein-N;
AltName: Full=12.1 kDa protein VIII;
AltName: Full=Protein VIII-N;
Contains:
RecName: Full=Hexon-linking protein-C;
AltName: Full=7.6 kDa protein VIII;
AltName: Full=Protein VIII-C;
Gene name
L4

Comments [?]

Function Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Subunit Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.
Subcellular location Pre-hexon-linking protein VIII: Host nucleus.
Hexon-linking protein-N: Virion. Note=Located on the inner side of the capsid shell. Present in 120 copies per virion.
Hexon-linking protein-C: Virion. Note=Located on the inner side of the capsid shell. Present in 120 copies per virion.
Induction Expressed in the late phase of the viral replicative cycle.
Ptm Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.
Miscellaneous All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Similarity Belongs to the adenoviridae hexon-linking protein family.

Keywords [?]


Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0019028; Cellular component: viral capsid.
GO:0019012; Cellular component: virion.

Cross-references [?]

Pfam PF01310; Adeno_PVIII; 1;

Features [?]

From: CAP8_ADE05 (P24936)
Key     From     To       Description   Tag   Condition   FTGroup
CHAIN     Nter     Cter       Pre-hexon-linking protein VIII        
PEPTIDE     Nter     111       Hexon-linking protein-N        
PROPEP     112     157                
PEPTIDE     158     Cter       Hexon-linking protein-C        
SITE     111     112       Cleavage; by viral protease        
SITE     157     158       Cleavage; by viral protease        
MOD_RES     64     64       Phosphothreonine; by host     T  
MOD_RES     118     118       Phosphoserine; by host     S  
MOD_RES     174     174       Phosphoserine; by host     S  

Additional information [?]

Size range 155-278 amino acids
Related rules None
Fusion None