HAMAP rule MF_04053

Accession	MF_04053
Dates	9-MAR-2017 (Created) 4-JUN-2021 (Last updated, Version 5)

Name

ADV_CORE5

Scope

Viruses; Mastadenovirus

Template

P36717 (CORE5_ADE12)

Triggered by

HAMAP; MF_04053 (Get profile general information and statistics)

Identifier

CORE5

Protein name

RecName: Full=Core-capsid bridging protein; AltName: Full=Core protein V;

Gene name

L2

Function	Associates loosely with the viral DNA to form an outer shell around the nucleoprotein-DNA complex and links it with the capsid by binding the endosome lysis protein. Dissociates from the viral genome during entry. Might be involved in nuclear capsid assembly of the viral particles through its association with NPM1/nucleophosmin.
Subunit	Monomer. Homodimer. Exists in equilibrium between monomers and dimers in solution. Interacts with the histone-like nucleoprotein; this interactions bridge the virus core to the capsid. Interacts with core protein X; this interactions bridge the virus core to the capsid. Interacts with the endosome lysis protein VI; this interactions bridge the virus core to the capsid. Interacts with the peripentonal hexons. Interacts with host NPM1; this interaction might play a role in virus assembly.
Subcellular location	Virion. Host nucleus, host nucleolus. Note=Located inside the capsid (core). Present in 157 copies per virion. Localizes in the nucleoli during infection, then translocates from the nucleoli to the nucleoplasm as the infection progresses and is finally incorporated into the viral particles.
Induction	Expressed in the late phase of the viral replicative cycle.
Miscellaneous	This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
	All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Similarity	Belongs to the adenoviridae core-capsid bridging protein family.

DNA-binding
Host nucleus
Late protein
Viral capsid assembly
Virion
Viral release from host cell

GO:0044196; Cellular component: host cell nucleolus.
GO:0044423; Cellular component: virion component.
GO:0003677; Molecular function: DNA binding.
GO:0019076; Biological process: viral release from host cell.

Pfam	PF03910; Adeno_PV; 1;

Size range	228-421 amino acids
Related rules	None
Fusion	None

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