HAMAP rule MF_04056

General rule information [?]

Accession	MF_04056
Dates	14-MAR-2017 (Created) 20-NOV-2019 (Last updated, Version 3)

Name

ADV_PVII

Scope

Viruses; Adenoviridae

Template

P68950 (NP_ADE02)

Triggered by

HAMAP; MF_04056 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

Protein name

RecName:		Full=Pre-histone-like nucleoprotein;
AltName:		Full=Pre-core protein VII;
		Short=pVII;
Contains:
	RecName:		Full=Histone-like nucleoprotein;
			Short=NP;
	AltName:		Full=Core protein VII;

Gene name

Comments [?]

Function	Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
Subunit	Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.
Subcellular location	Pre-histone-like nucleoprotein: Host nucleus, host nucleolus.
	Histone-like nucleoprotein: Virion. Note=Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.
Induction	Expressed in the late phase of the viral replicative cycle.
Ptm	Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.
Miscellaneous	All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Similarity	Belongs to the adenoviridae histone-like nucleoprotein family.

Keywords [?]

case <FTTag:Acet>

Acetylation

end case

DNA-binding
Host nucleus
Host-virus interaction
Late protein
Phosphoprotein
Viral penetration into host nucleus
Virion
Virus entry into host cell

Gene Ontology [?]

GO:0044196; Cellular component: host cell nucleolus.
GO:0003677; Molecular function: DNA binding.
GO:0046718; Biological process: viral entry into host cell.
GO:0075732; Biological process: viral penetration into host nucleus.

Cross-references [?]

Pfam	PF03228; Adeno_VII; 1;

Features [?]

From: NP_ADE02 (P68950)

Key From To Description Tag Condition FTGroup

INIT_MET 1 1 Removed M

CHAIN 2 Cter Pre-histone-like nucleoprotein

PROPEP 2 24

CHAIN 25 Cter Histone-like nucleoprotein

MOTIF 188 Cter Nuclear localization signal

SITE 24 25 Cleavage; by viral protease G-A

MOD_RES 2 2 N-acetylserine; by host Acet S

MOD_RES 27 27 N6-acetyllysine; by host Acet K

MOD_RES 48 48 N6-acetyllysine; by host Acet K

MOD_RES 55 55 Phosphothreonine; by host T

MOD_RES 74 74 Phosphothreonine; by host T

MOD_RES 183 183 Phosphoserine; by host S

MOD_RES 185 185 Phosphoserine; by host S

Additional information [?]

Size range	115-199 amino acids
Related rules	None
Fusion	None

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