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HAMAP rule MF_04056

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General rule information [?]

Accession MF_04056
Dates 14-MAR-2017 (Created)
1-MAR-2024 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P68950 (NP_ADE02); [ Recover all ]
Triggered by HAMAP; MF_04056 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NP
Protein name RecName: Full=Pre-histone-like nucleoprotein;
AltName: Full=Pre-core protein VII;
RecName: Full=Histone-like nucleoprotein;
AltName: Full=Core protein VII;
Gene name Name=L2;

Comments [?]

FUNCTIONPlays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
SUBUNITInteracts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone- like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.
SUBCELLULAR LOCATIONPre-histone-like nucleoprotein: Host nucleus, host nucleolus.
SUBCELLULAR LOCATIONHistone-like nucleoprotein: Virion. Note=Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.
INDUCTIONExpressed in the late phase of the viral replicative cycle.
PTMCleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.
MISCELLANEOUSAll late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
SIMILARITYBelongs to the adenoviridae histone-like nucleoprotein family.

Keywords [?]

Gene Ontology [?]

GO:0044196; Cellular component:host cell nucleolus
GO:0003677; Molecular function:DNA binding
GO:0046718; Biological process:symbiont entry into host cell
GO:0075732; Biological process:viral penetration into host nucleus

Cross-references [?]

Pfam PF03228; Adeno_VII; 1;

Features [?]

From: NP_ADE02 (P68950)
Key From To Description Tag Condition FTGroup
INIT_MET 1 1 /note="Removed" M
CHAIN 2 Cter /note="Pre-histone-like nucleoprotein"
CHAIN 25 Cter /note="Histone-like nucleoprotein"
MOTIF 188 Cter /note="Nuclear localization signal"
SITE 24 25 /note="Cleavage; by viral protease" G-A
MOD_RES 2 2 /note="N-acetylserine; by host" Acet S
MOD_RES 27 27 /note="N6-acetyllysine; by host" Acet K
MOD_RES 48 48 /note="N6-acetyllysine; by host" Acet K
MOD_RES 55 55 /note="Phosphothreonine; by host" T
MOD_RES 74 74 /note="Phosphothreonine; by host" T
MOD_RES 183 183 /note="Phosphoserine; by host" S
MOD_RES 185 185 /note="Phosphoserine; by host" S

Additional information [?]

Size range 115-199 amino acids
Related rules None
Fusion Nter: None Cter: None

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