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HAMAP rule MF_04056

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General rule information [?]

Accession MF_04056
Dates 14-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 3)
Viruses; Adenoviridae
Template P68950 (NP_ADE02)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Pre-histone-like nucleoprotein;
AltName: Full=Pre-core protein VII;
RecName: Full=Histone-like nucleoprotein;
AltName: Full=Core protein VII;
Gene name

Comments [?]

Function Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
Subunit Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.
Subcellular location Pre-histone-like nucleoprotein: Host nucleus, host nucleolus.
Histone-like nucleoprotein: Virion. Note=Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.
Induction Expressed in the late phase of the viral replicative cycle.
Ptm Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.
Miscellaneous All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Similarity Belongs to the adenoviridae histone-like nucleoprotein family.

Keywords [?]

case <FTTag:Acet>
end case

Gene Ontology [?]

GO:0044196; Cellular component: host cell nucleolus.
GO:0003677; Molecular function: DNA binding.
GO:0046718; Biological process: viral entry into host cell.
GO:0075732; Biological process: viral penetration into host nucleus.

Cross-references [?]

Pfam PF03228; Adeno_VII; 1;

Features [?]

From: NP_ADE02 (P68950)
Key     From     To       Description   Tag   Condition   FTGroup
INIT_MET     1     1       Removed     M  
CHAIN     2     Cter       Pre-histone-like nucleoprotein        
PROPEP     2     24                
CHAIN     25     Cter       Histone-like nucleoprotein        
MOTIF     188     Cter       Nuclear localization signal        
SITE     24     25       Cleavage; by viral protease     G-A  
MOD_RES     2     2       N-acetylserine; by host   Acet   S  
MOD_RES     27     27       N6-acetyllysine; by host   Acet   K  
MOD_RES     48     48       N6-acetyllysine; by host   Acet   K  
MOD_RES     55     55       Phosphothreonine; by host     T  
MOD_RES     74     74       Phosphothreonine; by host     T  
MOD_RES     183     183       Phosphoserine; by host     S  
MOD_RES     185     185       Phosphoserine; by host     S  

Additional information [?]

Size range 115-199 amino acids
Related rules None
Fusion None