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HAMAP rule MF_04058

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General rule information [?]

Accession MF_04058
Dates 16-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P03262 (PKG3_ADE02); [ Recover all ]
Triggered by HAMAP; MF_04058 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PKG3
Protein name RecName: Full=Packaging protein 3;
AltName: Full=L1-52/55 kDa protein;
AltName: Full=Packaging protein 52K;
Gene name Name=L1;

Comments [?]

FUNCTIONInvolved in viral genome packaging through its interaction with packaging proteins 1 and 2. After proteolyic cleavage by adenovirus protease, L1 52/55k protein is removed from the capsid during viral maturation.
SUBUNITPart of the genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with hexon-linking protein IIIa; this interaction is required to promote correct genome packaging.
SUBCELLULAR LOCATIONHost nucleus. Note=Nuclear protein present in empty capsids and assembly intermediates.
INDUCTIONExpressed in the early phase and late phase of the viral replicative cycle.
PTMCleaved at different sites by the viral protease during virion maturation.
MISCELLANEOUSAll late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
SIMILARITYBelongs to the adenoviridae packaging protein 3 family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0019073; Biological process:viral DNA genome packaging
GO:0019076; Biological process:viral release from host cell

Cross-references [?]

Pfam PF03052; Adeno_52K; 1;

Features [?]

From: PKG3_ADE02 (P03262)
Key From To Description Tag Condition FTGroup
REGION 1 173 /note="Interaction with packaging protein 1"
SITE 351 352 /note="Cleavage; by viral protease" T-G
MOD_RES 75 75 /note="Phosphoserine; by host" S
MOD_RES 360 360 /note="Phosphoserine; by host" S

Additional information [?]

Size range 322-415 amino acids
Related rules None
Fusion Nter: None Cter: None

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