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HAMAP rule MF_04058

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General rule information [?]

Accession MF_04058
Dates 16-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Viruses; Adenoviridae
Template P03262 (PKG3_ADE02)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Packaging protein 3;
AltName: Full=L1-52/55 kDa protein;
AltName: Full=Packaging protein 52K;
Gene name

Comments [?]

Function Involved in viral genome packaging through its interaction with packaging proteins 1 and 2. After proteolyic cleavage by adenovirus protease, L1 52/55k protein is removed from the capsid during viral maturation.
Subunit Part of the genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with hexon-linking protein IIIa; this interaction is required to promote correct genome packaging.
Subcellular location Host nucleus. Note=Nuclear protein present in empty capsids and assembly intermediates.
Induction Expressed in the early phase and late phase of the viral replicative cycle.
Ptm Cleaved at different sites by the viral protease during virion maturation.
Miscellaneous All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Similarity Belongs to the adenoviridae packaging protein 3 family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0019073; Biological process: viral DNA genome packaging.
GO:0019076; Biological process: viral release from host cell.

Cross-references [?]

Pfam PF03052; Adeno_52K; 1;

Features [?]

From: PKG3_ADE02 (P03262)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     1     173       Interaction with packaging protein 1        
SITE     351     352       Cleavage; by viral protease     T-G  
MOD_RES     75     75       Phosphoserine; by host     S  
MOD_RES     360     360       Phosphoserine; by host     S  

Additional information [?]

Size range 322-415 amino acids
Related rules None
Fusion None