HAMAP rule MF_04058
General rule information
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| Accession | MF_04058 |
| Dates | 16-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 4) |
| Name | ADV_PKG3 |
| Scope(s) |
Viruses Adenoviridae |
| Template(s) | P03262 (PKG3_ADE02); [ Recover all ] |
| Triggered by |
HAMAP; MF_04058 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PKG3 |
| Protein name | RecName: Full=Packaging protein 3; AltName: Full=L1-52/55 kDa protein; AltName: Full=Packaging protein 52K; |
| Gene name | Name=L1; |
Comments
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| FUNCTION | Involved in viral genome packaging through its interaction with packaging proteins 1 and 2. After proteolyic cleavage by adenovirus protease, L1 52/55k protein is removed from the capsid during viral maturation. |
| SUBUNIT | Part of the genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with hexon-linking protein IIIa; this interaction is required to promote correct genome packaging. |
| SUBCELLULAR LOCATION | Host nucleus. Note=Nuclear protein present in empty capsids and assembly intermediates. |
| INDUCTION | Expressed in the early phase and late phase of the viral replicative cycle. |
| PTM | Cleaved at different sites by the viral protease during virion maturation. |
| MISCELLANEOUS | All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell. |
| SIMILARITY | Belongs to the adenoviridae packaging protein 3 family. |
Keywords
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Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0019073; Biological process:viral DNA genome packaging |
| GO:0019076; Biological process:viral release from host cell |
Cross-references
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| Pfam | PF03052; Adeno_52K; 1; |
Features
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| From: PKG3_ADE02 (P03262) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 1 | 173 | /note="Interaction with packaging protein 1" | |||||||||
| SITE | 351 | 352 | /note="Cleavage; by viral protease" | T-G | ||||||||
| MOD_RES | 75 | 75 | /note="Phosphoserine; by host" | S | ||||||||
| MOD_RES | 360 | 360 | /note="Phosphoserine; by host" | S | ||||||||
Additional information
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| Size range | 322-415 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |