HAMAP logo
Due to maintenance work, this service will be unavailable on Monday between 06:00 until 06:30 CEST. Apologies for the inconvenience.

HAMAP rule MF_04062

Send feedback

General rule information [?]

Accession MF_04062
Dates 24-MAR-2017 (Created)
1-MAR-2024 (Last updated, Version 10)
Name INV_PB2
Scope(s) Viruses
Orthomyxoviridae
Template(s) P03428 (PB2_I34A1); [ Recover all ]
Triggered by HAMAP; MF_04062 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PB2
Protein name RecName: Full=Polymerase basic protein 2;
AltName: Full=RNA-directed RNA polymerase subunit P3;
Gene name Name=PB2;

Comments [?]

case <OC:Alphainfluenzavirus> and <FTTag:Hostd>
FUNCTIONPlays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7- methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
SUBUNITInfluenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N- terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response.
SUBCELLULAR LOCATIONVirion. Host nucleus. Host mitochondrion.
else case <OC:Alphainfluenzavirus> and not <FTTag:Hostd>
FUNCTIONPlays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7- methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
SUBUNITInfluenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).
SUBCELLULAR LOCATIONVirion. Host nucleus.
else
FUNCTIONPlays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
SUBUNITInfluenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).
SUBCELLULAR LOCATIONVirion. Host nucleus.
end case
SIMILARITYBelongs to the influenza viruses PB2 family.

Keywords [?]


Gene Ontology [?]

case <FTTag:Hostd>
GO:0039545; Biological process:symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
GO:0033650; Cellular component:host cell mitochondrion
end case
GO:0042025; Cellular component:host cell nucleus
GO:0044423; Cellular component:virion component
GO:0003723; Molecular function:RNA binding
GO:0003968; Molecular function:RNA-dependent RNA polymerase activity
GO:0006370; Biological process:7-methylguanosine mRNA capping
GO:0075526; Biological process:cap snatching
GO:0039523; Biological process:symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0006351; Biological process:DNA-templated transcription
GO:0019083; Biological process:viral transcription

Cross-references [?]

Pfam PF00604; Flu_PB2; 1;

Features [?]

From: PB2_I34A1 (P03428)
Key From To Description Tag Condition FTGroup
MOTIF 736 739 /note="Nuclear localization signal" K-R-K-R
case <OC:Alphainfluenzavirus>
SITE 627 627 /note="Mammalian adaptation" Hostd K
SITE 627 627 /note="Avian adaptation" HostA E
end case

Additional information [?]

Size range 759-774 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)