Home  |  Contact
Annotation rule MF_04062
Send feedback

General rule information [?]

Accession MF_04062
Dates 24-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 5)
Name INV_PB2
Scope
Viruses; Orthomyxoviridae
Template P03428 (PB2_I34A1)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PB2
Protein name
RecName: Full=Polymerase basic protein 2;
AltName: Full=RNA-directed RNA polymerase subunit P3;
Gene name
PB2

Comments [?]

case <OC:Alphainfluenzavirus> and <FTTag:Hostd>
Function Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response.
Subcellular location Virion. Host nucleus. Host mitochondrion.
else case <OC:Alphainfluenzavirus> and not <FTTag:Hostd>
Function Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).
Subcellular location Virion. Host nucleus.
else
Function Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).
Subcellular location Virion. Host nucleus.
end case
Similarity Belongs to the influenza viruses PB2 family.

Keywords [?]

case <FTTag:Hostd>
end case

Gene Ontology [?]

case <FTTag:Hostd>
GO:0039545; Biological process: suppression by virus of host MAVS activity.
GO:0033650; Cellular component: host cell mitochondrion.
end case
GO:0042025; Cellular component: host cell nucleus.
GO:0019012; Cellular component: virion.
GO:0003723; Molecular function: RNA binding.
GO:0003968; Molecular function: RNA-directed 5'-3' RNA polymerase activity.
GO:0006370; Biological process: 7-methylguanosine mRNA capping.
GO:0075526; Biological process: cap snatching.
GO:0039523; Biological process: suppression by virus of host RNA polymerase II activity.
GO:0006351; Biological process: transcription, DNA-templated.
GO:0019083; Biological process: viral transcription.

Cross-references [?]

Pfam PF00604; Flu_PB2; 1;

Features [?]

From: PB2_I34A1 (P03428)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     736     739       Nuclear localization signal     K-R-K-R  
case <OC:Alphainfluenzavirus>
SITE (Optional)     627     627       Mammalian adaptation   Hostd   K  
SITE (Optional)     627     627       Avian adaptation   HostA   E  
end case

Additional information [?]

Size range 759-774 amino acids
Related rules None
Fusion None