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HAMAP rule MF_04062

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General rule information [?]

Accession MF_04062
Dates 24-MAR-2017 (Created)
29-SEP-2022 (Last updated, Version 9)
Name INV_PB2
Scope
Viruses; Orthomyxoviridae
Template P03428 (PB2_I34A1)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PB2
Protein name
RecName: Full=Polymerase basic protein 2;
AltName: Full=RNA-directed RNA polymerase subunit P3;
Gene name
PB2

Comments [?]

case <OC:Alphainfluenzavirus> and <FTTag:Hostd>
Function Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response.
Subcellular location Virion. Host nucleus. Host mitochondrion.
else case <OC:Alphainfluenzavirus> and not <FTTag:Hostd>
Function Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).
Subcellular location Virion. Host nucleus.
else
Function Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).
Subcellular location Virion. Host nucleus.
end case
Similarity Belongs to the influenza viruses PB2 family.

Keywords [?]

Cap snatching
Eukaryotic host gene expression shutoff by virus
Eukaryotic host transcription shutoff by virus
Host gene expression shutoff by virus
Host nucleus
Host-virus interaction
case <FTTag:Hostd>
Inhibition of host innate immune response by virus
Inhibition of host MAVS by virus
Inhibition of host RLR pathway by virus
Viral immunoevasion
Host mitochondrion
end case
Inhibition of host RNA polymerase II by virus
mRNA capping
mRNA processing
Viral transcription
Virion

Gene Ontology [?]

case <FTTag:Hostd>
GO:0039545; Biological process: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity.
GO:0033650; Cellular component: host cell mitochondrion.
end case
GO:0042025; Cellular component: host cell nucleus.
GO:0044423; Cellular component: virion component.
GO:0003723; Molecular function: RNA binding.
GO:0003968; Molecular function: RNA-dependent RNA polymerase activity.
GO:0006370; Biological process: 7-methylguanosine mRNA capping.
GO:0075526; Biological process: cap snatching.
GO:0039523; Biological process: suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity.
GO:0006351; Biological process: DNA-templated transcription.
GO:0019083; Biological process: viral transcription.

Cross-references [?]

Pfam PF00604; Flu_PB2; 1;

Features [?]

From: PB2_I34A1 (P03428)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     736     739       Nuclear localization signal     K-R-K-R  
case <OC:Alphainfluenzavirus>
SITE (Optional)     627     627       Mammalian adaptation   Hostd   K  
SITE (Optional)     627     627       Avian adaptation   HostA   E  
end case

Additional information [?]

Size range 759-774 amino acids
Related rules None
Fusion None


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