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Annotation rule MF_04063
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General rule information [?]

Accession MF_04063
Dates 30-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Name INFV_PA
Scope
Viruses; Orthomyxoviridae
Template P03433 (PA_I34A1)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PA
Protein name
RecName: Full=Polymerase acidic protein;
EC 3.1.-.-;
AltName: Full=RNA-directed RNA polymerase subunit P2;
Gene name
PA

Comments [?]

Function Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via C-terminus) with PB1 (via N-terminus).
Subcellular location Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Ptm Phosphorylated on serines and threonines by host kinases, including human casein kinase II.
Similarity Belongs to the influenza viruses PA family.

Keywords [?]


Gene Ontology [?]

GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0003723; Molecular function: RNA binding.
GO:0075526; Biological process: cap snatching.
GO:0039523; Biological process: suppression by virus of host RNA polymerase II activity.
GO:0006351; Biological process: transcription, DNA-templated.

Cross-references [?]

Pfam PF00603; Flu_PA; 1;

Features [?]

From: PA_I34A1 (P03433)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     124     139       Nuclear localization signal 1 (NLS1)        
MOTIF     184     247       Nuclear localization signal 2 (NLS2)        
METAL     41     41       Manganese 1; via tele nitrogen     H  
METAL     80     80       Manganese 2     E  
METAL     108     108       Manganese 1     D  
METAL     108     108       Manganese 2     D  
METAL     119     119       Manganese 1     E  
METAL     120     120       Manganese 1; via carbonyl oxygen     [IV]  

Additional information [?]

Size range 709-726 amino acids
Related rules None
Fusion None