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HAMAP rule MF_04063

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General rule information [?]

Accession MF_04063
Dates 30-MAR-2017 (Created)
19-NOV-2022 (Last updated, Version 8)
Scope(s) Viruses
Template(s) P03433 (PA_I34A1); [ Recover all ]
Triggered by HAMAP; MF_04063 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PA
Protein name RecName: Full=Polymerase acidic protein;
AltName: Full=RNA-directed RNA polymerase subunit P2;
Gene name Name=PA;

Comments [?]

FUNCTIONPlays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit
SUBUNITInfluenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via C-terminus) with PB1 (via N-terminus).
SUBCELLULAR LOCATIONHost cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
PTMPhosphorylated on serines and threonines by host kinases, including human casein kinase II.
SIMILARITYBelongs to the influenza viruses PA family.

Keywords [?]

Gene Ontology [?]

GO:0030430; Cellular component:host cell cytoplasm
GO:0042025; Cellular component:host cell nucleus
GO:0003723; Molecular function:RNA binding
GO:0075526; Biological process:cap snatching
GO:0039523; Biological process:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

Pfam PF00603; Flu_PA; 1;

Features [?]

From: PA_I34A1 (P03433)
Key From To Description Tag Condition FTGroup
MOTIF 124 139 /note="Nuclear localization signal 1 (NLS1)"
MOTIF 184 247 /note="Nuclear localization signal 2 (NLS2)"
BINDING 41 41 /ligand="Mn(2+)"
BINDING 80 80 /ligand="Mn(2+)"
BINDING 108 108 /ligand="Mn(2+)"
BINDING 108 108 /ligand="Mn(2+)"
BINDING 119 119 /ligand="Mn(2+)"
BINDING 120 120 /ligand="Mn(2+)"

Additional information [?]

Size range 709-726 amino acids
Related rules None
Fusion Nter: None Cter: None

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