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HAMAP rule MF_04064

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General rule information [?]

Accession MF_04064
Dates 31-MAR-2017 (Created)
13-OCT-2023 (Last updated, Version 7)
Scope(s) Viruses
Template(s) P0C0U1 (PB1F2_I34A1); [ Recover all ]
Triggered by HAMAP; MF_04064 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PB1F2
Protein name RecName: Full=Protein PB1-F2;
Gene name Name=PB1;

Comments [?]

case <FTTag:Signal>
FUNCTIONPlays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
SUBUNITOligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.
SUBCELLULAR LOCATIONHost mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
FUNCTIONMay play an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.
SUBCELLULAR LOCATIONHost nucleus. Host cytoplasm, host cytosol.
end case
SIMILARITYBelongs to the influenza viruses PB1-F2 family.

Keywords [?]

Gene Ontology [?]

GO:0044164; Cellular component:host cell cytosol
GO:0016020; Cellular component:membrane
case <FTTag:Signal>
GO:0044192; Cellular component:host cell mitochondrial inner membrane
GO:0042025; Cellular component:host cell nucleus
GO:0039526; Biological process:perturbation by virus of host apoptosis
GO:0032688; Biological process:negative regulation of interferon-beta production
GO:0039545; Biological process:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
end case

Cross-references [?]

Pfam PF11986; PB1-F2; 1;

Features [?]

From: PB1F2_I34A1 (P0C0U1)
Key From To Description Tag Condition FTGroup
REGION 65 87 /note="Mitochondrial targeting sequence" Signal [KR]-x*-[EG]
SITE 66 66 /note="High pathogenicity" S
SITE 66 66 /note="Low pathogenicity" N

Additional information [?]

Size range 11-90 amino acids
Related rules None
Fusion Nter: None Cter: None

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