HAMAP rule MF_04064
General rule information
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| Accession | MF_04064 |
| Dates | 31-MAR-2017 (Created)
13-OCT-2023 (Last updated, Version 7) |
| Name | INFV_PB1F2 |
| Scope(s) |
Viruses Orthomyxoviridae |
| Template(s) | P0C0U1 (PB1F2_I34A1); [ Recover all ] |
| Triggered by |
HAMAP; MF_04064 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PB1F2 |
| Protein name | RecName: Full=Protein PB1-F2; |
| Gene name | Name=PB1; |
Comments
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| case <FTTag:Signal> | |
| FUNCTION | Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis. |
| SUBUNIT | Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS. |
| SUBCELLULAR LOCATION | Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol. |
| else | |
| FUNCTION | May play an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. |
| SUBCELLULAR LOCATION | Host nucleus. Host cytoplasm, host cytosol. |
| end case | |
| SIMILARITY | Belongs to the influenza viruses PB1-F2 family. |
Keywords
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Gene Ontology
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| GO:0044164; Cellular component:host cell cytosol | |
| GO:0016020; Cellular component:membrane | |
| case <FTTag:Signal> | |
| GO:0044192; Cellular component:host cell mitochondrial inner membrane | |
| GO:0042025; Cellular component:host cell nucleus | |
| GO:0039526; Biological process:perturbation by virus of host apoptosis | |
| GO:0032688; Biological process:negative regulation of interferon-beta production | |
| GO:0039545; Biological process:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity | |
| end case | |
Cross-references
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| Pfam | PF11986; PB1-F2; 1; |
Features
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| From: PB1F2_I34A1 (P0C0U1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 65 | 87 | /note="Mitochondrial targeting sequence" | Signal | [KR]-x*-[EG] | |||||||
| SITE | 66 | 66 | /note="High pathogenicity" | S | ||||||||
| SITE | 66 | 66 | /note="Low pathogenicity" | N | ||||||||
Additional information
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| Size range | 11-90 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |