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HAMAP rule MF_04064

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General rule information [?]

Accession MF_04064
Dates 31-MAR-2017 (Created)
28-OCT-2021 (Last updated, Version 6)
Name INFV_PB1F2
Scope
Viruses; Orthomyxoviridae
Template P0C0U1 (PB1F2_I34A1)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PB1F2
Protein name
RecName: Full=Protein PB1-F2;
Gene name
PB1

Comments [?]

case <FTTag:Signal>
Function Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
Subunit Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.
Subcellular location Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
else
Function May play an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.
Subcellular location Host nucleus. Host cytoplasm, host cytosol.
end case
Similarity Belongs to the influenza viruses PB1-F2 family.

Keywords [?]

Host cytoplasm
Host nucleus
case <FTTag:Signal>
Apoptosis
Host membrane
Host mitochondrion
Host mitochondrion inner membrane
Host-virus interaction
Inhibition of host innate immune response by virus
Inhibition of host MAVS by virus
Inhibition of host RLR pathway by virus
Membrane
Modulation of host cell apoptosis by virus
Viral immunoevasion
end case

Gene Ontology [?]

GO:0044164; Cellular component: host cell cytosol.
GO:0016020; Cellular component: membrane.
case <FTTag:Signal>
GO:0044192; Cellular component: host cell mitochondrial inner membrane.
GO:0042025; Cellular component: host cell nucleus.
GO:0039526; Biological process: modulation by virus of host apoptotic process.
GO:0032688; Biological process: negative regulation of interferon-beta production.
GO:0039545; Biological process: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity.
end case

Cross-references [?]

Pfam PF11986; PB1-F2; 1;

Features [?]

From: PB1F2_I34A1 (P0C0U1)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     65     87       Mitochondrial targeting sequence   Signal   [KR]-x*-[EG]  
SITE     66     66       High pathogenicity     S  
SITE     66     66       Low pathogenicity     N  

Additional information [?]

Size range 11-90 amino acids
Related rules None
Fusion None


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