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HAMAP rule MF_04065

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General rule information [?]

Accession MF_04065
Dates 4-APR-2017 (Created)
29-SEP-2022 (Last updated, Version 9)
Viruses; Orthomyxoviridae
Template P03431 (RDRP_I34A1)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=RNA-directed RNA polymerase catalytic subunit;
AltName: Full=Polymerase basic protein 1;
AltName: Full=RNA-directed RNA polymerase subunit P1;
Gene name

Comments [?]

Function RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copies vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
Catalytic activity RHEA:21248: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Subunit Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PA (via C-terminus). Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation.
Subcellular location Host nucleus. Host cytoplasm.
Ptm Phosphorylated by host PRKCA.
Similarity Belongs to the influenza viruses polymerase PB1 family.

Keywords [?]

Gene Ontology [?]

GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0000166; Molecular function: nucleotide binding.
GO:0003968; Molecular function: RNA-dependent RNA polymerase activity.
GO:0039523; Biological process: suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity.
GO:0006351; Biological process: DNA-templated transcription.
GO:0039694; Biological process: viral RNA genome replication.

Cross-references [?]

Pfam PF00602; Flu_PB1; 1;
PIRSF PIRSF000827; RdRPol_OMV; 1;

Features [?]

From: RDRP_I34A1 (P03431)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     286     483       RdRp catalytic        
REGION     249     256       Promoter-binding site        
MOTIF     187     195       Nuclear localization signal        
MOTIF     203     216       Nuclear localization signal        

Additional information [?]

Size range 751-758 amino acids
Related rules None
Fusion None