HAMAP rule MF_04065
General rule information
[?]
| Accession | MF_04065 |
| Dates | 4-APR-2017 (Created) 29-SEP-2022 (Last updated, Version 9) |
| Name | INFV_RDRP |
| Scope | Viruses; Orthomyxoviridae |
| Template | P03431 (RDRP_I34A1) |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||||||||||||||||||
| Gene name |
|
Comments
[?]
| Function | RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copies vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs. |
| Catalytic activity | RHEA:21248: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
EC 2.7.7.48 |
| Subunit | Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PA (via C-terminus). Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation. |
| Subcellular location | Host nucleus. Host cytoplasm. |
| Ptm | Phosphorylated by host PRKCA. |
| Similarity | Belongs to the influenza viruses polymerase PB1 family. |
Keywords
[?]
Eukaryotic host gene expression shutoff by virus
Eukaryotic host transcription shutoff by virus
Host cytoplasm
Host gene expression shutoff by virus
Host nucleus
Host-virus interaction
Inhibition of host RNA polymerase II by virus
Nucleotide-binding
Nucleotidyltransferase
Phosphoprotein
RNA-directed RNA polymerase
Transferase
Viral RNA replication
Viral transcription
Eukaryotic host transcription shutoff by virus
Host cytoplasm
Host gene expression shutoff by virus
Host nucleus
Host-virus interaction
Inhibition of host RNA polymerase II by virus
Nucleotide-binding
Nucleotidyltransferase
Phosphoprotein
RNA-directed RNA polymerase
Transferase
Viral RNA replication
Viral transcription
Gene Ontology
[?]
GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0000166; Molecular function: nucleotide binding.
GO:0003968; Molecular function: RNA-dependent RNA polymerase activity.
GO:0039523; Biological process: suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity.
GO:0006351; Biological process: DNA-templated transcription.
GO:0039694; Biological process: viral RNA genome replication.
GO:0042025; Cellular component: host cell nucleus.
GO:0000166; Molecular function: nucleotide binding.
GO:0003968; Molecular function: RNA-dependent RNA polymerase activity.
GO:0039523; Biological process: suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity.
GO:0006351; Biological process: DNA-templated transcription.
GO:0039694; Biological process: viral RNA genome replication.
Cross-references
[?]
| PROSITE | PS50525; RDRP_SSRNA_NEG_SEG; 1; |
| Pfam | PF00602; Flu_PB1; 1; |
| PIRSF | PIRSF000827; RdRPol_OMV; 1; |
Features
[?]
| From: RDRP_I34A1 (P03431) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | 286 | 483 | RdRp catalytic | |||||||||
| REGION | 249 | 256 | Promoter-binding site | |||||||||
| MOTIF | 187 | 195 | Nuclear localization signal | |||||||||
| MOTIF | 203 | 216 | Nuclear localization signal | |||||||||
Additional information
[?]
| Size range | 751-758 amino acids |
| Related rules | None |
| Fusion | None |