HAMAP rule MF_04067
General rule information
[?]
| Accession | MF_04067 |
| Dates | 10-APR-2017 (Created)
4-JUN-2021 (Last updated, Version 6) |
| Name | INFV_NEP |
| Scope(s) |
Viruses Orthomyxoviridae |
| Template(s) | P03508 (NEP_I34A1); Q01640 (NEP_INCAA); [ Recover all ] |
| Triggered by |
HAMAP; MF_04067 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | NEP |
| Protein name | RecName: Full=Nuclear export protein; Short=NEP; AltName: Full=Non-structural protein 2; Short=NS2; |
| Gene name | Name=NS; |
Comments
[?]
| FUNCTION | Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced. |
| SUBUNIT | Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1. |
| SUBCELLULAR LOCATION | Virion. Host nucleus. |
| SIMILARITY | Belongs to the influenza viruses NEP family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0042025; Cellular component:host cell nucleus |
| GO:0044423; Cellular component:virion component |
| GO:0039675; Biological process:exit of virus from host cell nucleus through nuclear pore |
| GO:0006405; Biological process:RNA export from nucleus |
Cross-references
[?]
Features
[?]
| From: NEP_I34A1 (P03508) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Alphainfluenzavirus> or <OC:Betainfluenzavirus> | ||||||||||||
| MOTIF | 12 | 21 | /note="Nuclear export signal" | |||||||||
| MOTIF | 85 | 94 | /note="Nuclear export signal" | |||||||||
| end case | ||||||||||||
| From: NEP_INCAA (Q01640) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Gammainfluenzavirus> | ||||||||||||
| MOTIF | 96 | 105 | /note="Nuclear export signal" | |||||||||
| MOTIF | 122 | 132 | /note="Nuclear export signal" | |||||||||
| end case | ||||||||||||
Additional information
[?]
| Size range | 121-182 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |