HAMAP logo

HAMAP rule MF_04067

Send feedback

General rule information [?]

Accession MF_04067
Dates 10-APR-2017 (Created)
4-JUN-2021 (Last updated, Version 6)
Scope(s) Viruses
Template(s) P03508 (NEP_I34A1); Q01640 (NEP_INCAA); [ Recover all ]
Triggered by HAMAP; MF_04067 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NEP
Protein name RecName: Full=Nuclear export protein;
AltName: Full=Non-structural protein 2;
Gene name Name=NS;

Comments [?]

FUNCTIONMediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
SUBUNITInteracts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.
SIMILARITYBelongs to the influenza viruses NEP family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0044423; Cellular component:virion component
GO:0039675; Biological process:exit of virus from host cell nucleus through nuclear pore
GO:0006405; Biological process:RNA export from nucleus

Cross-references [?]

Pfam PF00601; Flu_NS2; 1;
Pfam PF03555; Flu_C_NS2; 1;

Features [?]

From: NEP_I34A1 (P03508)
Key From To Description Tag Condition FTGroup
case <OC:Alphainfluenzavirus> or <OC:Betainfluenzavirus>
MOTIF 12 21 /note="Nuclear export signal"
MOTIF 85 94 /note="Nuclear export signal"
end case
From: NEP_INCAA (Q01640)
Key From To Description Tag Condition FTGroup
case <OC:Gammainfluenzavirus>
MOTIF 96 105 /note="Nuclear export signal"
MOTIF 122 132 /note="Nuclear export signal"
end case

Additional information [?]

Size range 121-182 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)