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Annotation rule MF_04067
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General rule information [?]

Accession MF_04067
Dates 10-APR-2017 (Created)
20-NOV-2019 (Last updated, Version 5)
Name INFV_NEP
Scope
Viruses; Orthomyxoviridae
Templates P03508 (NEP_I34A1); Q01640 (NEP_INCAA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NEP
Protein name
RecName: Full=Nuclear export protein;
Short=NEP;
AltName: Full=Non-structural protein 2;
Short=NS2;
Gene name
NS

Comments [?]

Function Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
Subunit Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.
Subcellular location Virion. Host nucleus.
Similarity Belongs to the influenza viruses NEP family.

Keywords [?]


Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0019012; Cellular component: virion.
GO:0039675; Biological process: exit of virus from host cell nucleus through nuclear pore.
GO:0006405; Biological process: RNA export from nucleus.

Cross-references [?]

Pfam PF00601; Flu_NS2; 1;
PF03555; Flu_C_NS2; 1;

Features [?]

case <OC:Alphainfluenzavirus> or <OC:Betainfluenzavirus>
From: NEP_I34A1 (P03508)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     12     21       Nuclear export signal        
MOTIF     85     94       Nuclear export signal        
end case
case <OC:Gammainfluenzavirus>
From: NEP_INCAA (Q01640)
MOTIF     96     105       Nuclear export signal        
MOTIF     122     132       Nuclear export signal        
end case

Additional information [?]

Size range 121-182 amino acids
Related rules None
Fusion None