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HAMAP rule MF_04068

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General rule information [?]

Accession MF_04068
Dates 10-APR-2017 (Created)
20-NOV-2019 (Last updated, Version 3)
Name INFV_M1
Scope(s) Viruses
Template(s) P03485 (M1_I34A1); [ Recover all ]
Triggered by HAMAP; MF_04068 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier M1
Protein name RecName: Full=Matrix protein 1;
Gene name Name=M;

Comments [?]

FUNCTIONPlays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.
FUNCTIONDetermines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
SUBUNITHomodimer and homomultimer. Interacts with NEP. Binds ribonucleocapsid by both interacting with genomic RNA and NP protein. May interact with HA and NA. Cannot bind NP without genomic RNA.
SUBCELLULAR LOCATIONVirion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
MISCELLANEOUSMost abundant protein in virion. When expressed alone can form virus-like particles in transfected cells.
SIMILARITYBelongs to the influenza viruses Matrix protein M1 family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0055036; Cellular component:virion membrane
GO:0003723; Molecular function:RNA binding
GO:0039660; Molecular function:structural constituent of virion
GO:0046761; Biological process:viral budding from plasma membrane

Cross-references [?]

Pfam PF00598; Flu_M1; 1;
Pfam PF08289; Flu_M1_C; 1;

Features [?]

From: M1_I34A1 (P03485)
Key From To Description Tag Condition FTGroup
REGION 1 164 /note="Membrane-binding"
REGION 165 252 /note="RNP-binding"
MOTIF 101 105 /note="Nuclear localization signal"

Additional information [?]

Size range 248-252 amino acids
Related rules None
Fusion Nter: None Cter: None

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