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Annotation rule MF_04096
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General rule information [?]

Accession MF_04096
Dates 19-MAR-2018 (Created)
20-NOV-2019 (Last updated, Version 3)
Name BETA_CORONA_NCAP
Scope
Viruses; Betacoronavirus
Templates P03416 (NCAP_CVMA5); P59595 (NCAP_SARS): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NCAP
Protein name
RecName: Full=Nucleoprotein;
AltName: Full=Nucleocapsid protein;
Short=NC;
Short=Protein N;
Gene name
N

Comments [?]

Function Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Subcellular location Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Ptm ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues.
Similarity Belongs to the betacoronavirus nucleocapsid protein family.

Keywords [?]


Gene Ontology [?]

GO:0044172; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019013; Cellular component: viral nucleocapsid.
GO:0003723; Molecular function: RNA binding.

Cross-references [?]

Pfam PF00937; Corona_nucleoca; 1;
PIRSF PIRSF003888; Corona_nucleocap; 1;

Features [?]

From: NCAP_CVMA5 (P03416)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     56     197       RNA-binding        
REGION     267     383       Dimerization        
MOD_RES     162     162       Phosphoserine; by host     S  
MOD_RES     170     170       Phosphoserine; by host     S  
MOD_RES     177     177       Phosphothreonine; by host     T  
MOD_RES     389     389       Phosphoserine; by host     S  
MOD_RES     424     424       Phosphoserine; by host     S  
MOD_RES     428     428       Phosphothreonine; by host     T  
From: NCAP_CVHSA (P59595)
MOD_RES     177     177       Phosphoserine; by host     S  

Additional information [?]

Size range 411-468 amino acids
Related rules None
Fusion None