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HAMAP rule MF_04096

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General rule information [?]

Accession MF_04096
Dates 19-MAR-2018 (Created)
25-MAR-2021 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P03416 (NCAP_CVMA5); P59595 (NCAP_SARS); [ Recover all ]
Triggered by HAMAP; MF_04096 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NCAP
Protein name RecName: Full=Nucleoprotein;
AltName: Full=Nucleocapsid protein;
                 Short=Protein N;
Gene name Name=N;

Comments [?]

FUNCTIONPackages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
SUBUNITHomooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
SUBCELLULAR LOCATIONVirion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER- derived membranes where it participates in viral RNA synthesis and virus budding.
PTMADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
PTMPhosphorylated on serine and threonine residues.
SIMILARITYBelongs to the betacoronavirus nucleocapsid protein family.

Keywords [?]

Gene Ontology [?]

GO:0044172; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177; Cellular component:host cell Golgi apparatus
GO:0019013; Cellular component:viral nucleocapsid
GO:0003723; Molecular function:RNA binding

Cross-references [?]

Pfam PF00937; Corona_nucleoca; 1;
PIRSF PIRSF003888; Corona_nucleocap; 1;

Features [?]

From: NCAP_CVMA5 (P03416)
Key From To Description Tag Condition FTGroup
REGION 56 197 /note="RNA-binding"
REGION 267 383 /note="Dimerization"
MOD_RES 162 162 /note="Phosphoserine; by host" S
MOD_RES 170 170 /note="Phosphoserine; by host" S
MOD_RES 177 177 /note="Phosphothreonine; by host" T
MOD_RES 389 389 /note="Phosphoserine; by host" S
MOD_RES 424 424 /note="Phosphoserine; by host" S
MOD_RES 428 428 /note="Phosphothreonine; by host" T
From: NCAP_SARS (P59595)
Key From To Description Tag Condition FTGroup
MOD_RES 177 177 /note="Phosphoserine; by host" S

Additional information [?]

Size range 411-468 amino acids
Related rules None
Fusion Nter: None Cter: None

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