HAMAP rule MF_04096
General rule information
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| Accession | MF_04096 |
| Dates | 19-MAR-2018 (Created)
25-MAR-2021 (Last updated, Version 4) |
| Name | BETA_CORONA_NCAP |
| Scope(s) |
Viruses Betacoronavirus |
| Template(s) | P03416 (NCAP_CVMA5); P59595 (NCAP_SARS); [ Recover all ] |
| Triggered by |
HAMAP; MF_04096 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NCAP |
| Protein name | RecName: Full=Nucleoprotein; AltName: Full=Nucleocapsid protein; Short=NC; Short=Protein N; |
| Gene name | Name=N; |
Comments
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| FUNCTION | Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. |
| SUBUNIT | Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection. |
| SUBCELLULAR LOCATION | Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER- derived membranes where it participates in viral RNA synthesis and virus budding. |
| PTM | ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection. |
| PTM | Phosphorylated on serine and threonine residues. |
| SIMILARITY | Belongs to the betacoronavirus nucleocapsid protein family. |
Keywords
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| ADP-ribosylation |
| Host Golgi apparatus |
| Phosphoprotein |
| Ribonucleoprotein |
| RNA-binding |
| Transcription |
| Transcription regulation |
| Viral nucleoprotein |
| Virion |
Gene Ontology
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| GO:0044172; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment |
| GO:0044177; Cellular component:host cell Golgi apparatus |
| GO:0019013; Cellular component:viral nucleocapsid |
| GO:0003723; Molecular function:RNA binding |
Cross-references
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| Pfam | PF00937; Corona_nucleoca; 1; |
| PIRSF | PIRSF003888; Corona_nucleocap; 1; |
Features
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| From: NCAP_CVMA5 (P03416) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 56 | 197 | /note="RNA-binding" | |||||||||
| REGION | 267 | 383 | /note="Dimerization" | |||||||||
| MOD_RES | 162 | 162 | /note="Phosphoserine; by host" | S | ||||||||
| MOD_RES | 170 | 170 | /note="Phosphoserine; by host" | S | ||||||||
| MOD_RES | 177 | 177 | /note="Phosphothreonine; by host" | T | ||||||||
| MOD_RES | 389 | 389 | /note="Phosphoserine; by host" | S | ||||||||
| MOD_RES | 424 | 424 | /note="Phosphoserine; by host" | S | ||||||||
| MOD_RES | 428 | 428 | /note="Phosphothreonine; by host" | T | ||||||||
| From: NCAP_SARS (P59595) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 177 | 177 | /note="Phosphoserine; by host" | S | ||||||||
Additional information
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| Size range | 411-468 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |