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HAMAP rule MF_04105

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General rule information [?]

Accession MF_04105
Dates 18-OCT-2016 (Created)
1-DEC-2022 (Last updated, Version 9)
Viruses; Caudoviricetes
Template P13304 (ANTIH_BPT4)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Antiholin;
Flags: Precursor;

Comments [?]

Function Involved in lysis inhibition. Senses superinfections and inhibits the holin, thereby delaying the host cell lysis timing. The genomic DNA from the superinfecting phage bound to the complex holin-antiholin probably serves as a signal for the lysis inhibition and blocks the holin multimerization.
Subunit Homotetramer; in free-form. Homomultimer. Heterotetramer composed of 2 holin and 2 antiholin. The holin-antiholin complex binds dsDNA. Interacts (via C-terminus) with holin (via C-terminus); this interaction blocks the holin homomultimerization and delays the host cell lysis.
Subcellular location Host periplasm.
case <FTTag:disulf>
Ptm Disulfide bond is required for functionality.
end case
Similarity Belongs to the T4likevirus antiholin family.

Keywords [?]

case <FTTag:disulf>
end case

Gene Ontology [?]

GO:0140678; Molecular function: molecular function inhibitor activity.

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: ANTIH_BPT4 (P13304)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     69     75           disulf   C-x*-C  

Additional information [?]

Size range 93-100 amino acids
Related rules None
Fusion None