HAMAP rule MF_04105
General rule information
[?]
| Accession | MF_04105 |
| Dates | 18-OCT-2016 (Created)
1-DEC-2022 (Last updated, Version 9) |
| Name | ANTIH_T4 |
| Scope(s) |
Viruses Caudoviricetes |
| Template(s) | P13304 (ANTIH_BPT4); [ Recover all ] |
| Triggered by |
HAMAP; MF_04105 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | ANTIH |
| Protein name | RecName: Full=Antiholin; Flags: Precursor; |
Comments
[?]
| FUNCTION | Involved in lysis inhibition. Senses superinfections and inhibits the holin, thereby delaying the host cell lysis timing. The genomic DNA from the superinfecting phage bound to the complex holin- antiholin probably serves as a signal for the lysis inhibition and blocks the holin multimerization. |
| SUBUNIT | Homotetramer; in free-form. Homomultimer. Heterotetramer composed of 2 holin and 2 antiholin. The holin-antiholin complex binds dsDNA. Interacts (via C-terminus) with holin (via C-terminus); this interaction blocks the holin homomultimerization and delays the host cell lysis. |
| SUBCELLULAR LOCATION | Host periplasm. |
| case <FTTag:disulf> | |
| PTM | Disulfide bond is required for functionality. |
| end case | |
| SIMILARITY | Belongs to the T4likevirus antiholin family. |
Keywords
[?]
| Cytolysis | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
| Host cell lysis by virus | |
| Signal | |
| Host periplasm | |
| Viral release from host cell | |
| DNA-binding | |
Gene Ontology
[?]
| GO:0140678; Molecular function:molecular function inhibitor activity |
Cross-references
[?]
| General | Signal; -; 1; |
Features
[?]
| From: ANTIH_BPT4 (P13304) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 69 | 75 | disulf | C-x*-C | ||||||||
Additional information
[?]
| Size range | 93-100 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |