Home  |  Contact
Annotation rule MF_04105
Send feedback

General rule information [?]

Accession MF_04105
Dates 18-OCT-2016 (Created)
31-MAY-2022 (Last updated, Version 7)
Name ANTIH_T4
Scope
Viruses; Caudovirales
Template P13304 (ANTIH_BPT4)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ANTIH
Protein name
RecName: Full=Antiholin;
Flags: Precursor;

Comments [?]

Function Involved in lysis inhibition. Senses superinfections and inhibits the holin, thereby delaying the host cell lysis timing. The genomic DNA from the superinfecting phage bound to the complex holin-antiholin probably serves as a signal for the lysis inhibition and blocks the holin multimerization.
Subunit Homotetramer; in free-form. Homomultimer. Heterotetramer composed of 2 holin and 2 antiholin. The holin-antiholin complex binds dsDNA. Interacts (via C-terminus) with holin (via C-terminus); this interaction blocks the holin homomultimerization and delays the host cell lysis.
Subcellular location Host periplasm.
case <FTTag:disulf>
Ptm Disulfide bond is required for functionality.
end case
Similarity Belongs to the T4likevirus antiholin family.

Keywords [?]

Cytolysis
case <FTTag:disulf>
Disulfide bond
end case
Host cell lysis by virus
Signal
Host periplasm
Viral release from host cell
DNA-binding

Gene Ontology [?]

GO:1901218; Biological process: negative regulation of holin activity.

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: ANTIH_BPT4 (P13304)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     69     75           disulf   C-x*-C  

Additional information [?]

Size range 93-100 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)