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Annotation rule MF_04105
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General rule information [?]

Accession MF_04105
Dates 18-OCT-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Viruses; Caudovirales
Template P13304 (ANTIH_BPT4)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Antiholin;

Comments [?]

Function Involved in lysis inhibition. Interacts with and inhibits the holin thereby delaying the host cell lysis timing. Lysis inhibition is imposed when a cell infected by a T4-like virus is superinfected by new incoming viruses. This is probably due to the capsid content of the new phage being released in the periplasm because of blockage of entry due to superinfection exclusion. These periplasmically released viral proteins must somehow activate the periplasmic antiholin, which in turn will block the holin multimerization.
Subunit Interacts (via C-terminus) with holin (via C-terminus); this interaction blocks the holin homomultimerization and delays the host cell lysis.
Subcellular location Host cell inner membrane; Single-pass type II membrane protein.
Domain The transmembrane signal-anchor domain can escape spontaneously from the cell inner membrane. It is called SAR for signal-anchor-release for that reason and explains why the antiholin is an extremly instable protein. Superinfection might stabilize it so that it can inhibit holin multimerization and delay lysis.
case <FTTag:disulf>
Ptm Disulfide bond is required for functionality.
end case
Similarity Belongs to the T4likevirus antiholin family.

Keywords [?]

case <FTTag:disulf>
end case

Gene Ontology [?]

GO:0020002; Cellular component: host cell plasma membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:1901218; Biological process: negative regulation of holin activity.

Features [?]

From: ANTIH_BPT4 (P13304)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     Nter     24       Helical; Signal-anchor for type II membrane protein        
TOPO_DOM     25     Cter       Periplasmic        
DISULFID     69     75           disulf   C-x*-C  

Additional information [?]

Size range 93-100 amino acids
Related rules None
Fusion None