HAMAP rule MF_04105
General rule information
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| Accession | MF_04105 |
| Dates | 18-OCT-2016 (Created) 1-DEC-2022 (Last updated, Version 9) |
| Name | ANTIH_T4 |
| Scope | Viruses; Caudoviricetes |
| Template | P13304 (ANTIH_BPT4) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | Involved in lysis inhibition. Senses superinfections and inhibits the holin, thereby delaying the host cell lysis timing. The genomic DNA from the superinfecting phage bound to the complex holin-antiholin probably serves as a signal for the lysis inhibition and blocks the holin multimerization. |
| Subunit | Homotetramer; in free-form. Homomultimer. Heterotetramer composed of 2 holin and 2 antiholin. The holin-antiholin complex binds dsDNA. Interacts (via C-terminus) with holin (via C-terminus); this interaction blocks the holin homomultimerization and delays the host cell lysis. |
| Subcellular location | Host periplasm. |
case <FTTag:disulf>
| Ptm | Disulfide bond is required for functionality. |
end case
| Similarity | Belongs to the T4likevirus antiholin family. |
Keywords
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case <FTTag:disulf>
end case
Gene Ontology
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GO:0140678; Molecular function: molecular function inhibitor activity.
Computed features
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| General | Signal; -; 1; trigger=yes; |
Features
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| From: ANTIH_BPT4 (P13304) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 69 | 75 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 93-100 amino acids |
| Related rules | None |
| Fusion | None |