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HAMAP rule MF_04105

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General rule information [?]

Accession MF_04105
Dates 18-OCT-2016 (Created)
1-DEC-2022 (Last updated, Version 9)
Scope(s) Viruses
Template(s) P13304 (ANTIH_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ANTIH
Protein name RecName: Full=Antiholin;
                 Flags: Precursor;

Comments [?]

FUNCTIONInvolved in lysis inhibition. Senses superinfections and inhibits the holin, thereby delaying the host cell lysis timing. The genomic DNA from the superinfecting phage bound to the complex holin- antiholin probably serves as a signal for the lysis inhibition and blocks the holin multimerization.
SUBUNITHomotetramer; in free-form. Homomultimer. Heterotetramer composed of 2 holin and 2 antiholin. The holin-antiholin complex binds dsDNA. Interacts (via C-terminus) with holin (via C-terminus); this interaction blocks the holin homomultimerization and delays the host cell lysis.
case <FTTag:disulf>
PTMDisulfide bond is required for functionality.
end case
SIMILARITYBelongs to the T4likevirus antiholin family.

Keywords [?]

Gene Ontology [?]

GO:0140678; Molecular function:molecular function inhibitor activity

Cross-references [?]

General Signal; -; 1;

Features [?]

From: ANTIH_BPT4 (P13304)
Key From To Description Tag Condition FTGroup
DISULFID 69 75 disulf C-x*-C

Additional information [?]

Size range 93-100 amino acids
Related rules None
Fusion Nter: None Cter: None

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