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Annotation rule MF_04109
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General rule information [?]

Accession MF_04109
Dates 2-NOV-2016 (Created)
23-MAR-2020 (Last updated, Version 6)
Viruses; Caudovirales
Template P03706 (ENLYS_LAMBD)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Endolysin;
EC 4.2.2.n2;
AltName: Full=Transglycosylase;
AltName: Full=Lysozyme;
AltName: Full=Lysis protein;

Comments [?]

Function Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
Catalytic activity Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2;
Subunit Monomer.
Subcellular location Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.
Similarity Belongs to the glycosyl hydrolase 24 family.

Keywords [?]

Gene Ontology [?]

GO:0003796; Molecular function: lysozyme activity.
GO:0016829; Molecular function: lyase activity.
GO:0044659; Biological process: viral release from host cell by cytolysis.
GO:0009253; Biological process: peptidoglycan catabolic process.

Cross-references [?]

Pfam PF00959; Phage_lysozyme; 1;

Features [?]

From: ENLYS_LAMBD (P03706)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     19     19             E  

Additional information [?]

Size range 153-181 amino acids
Related rules None
Fusion None