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HAMAP rule MF_04109

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General rule information [?]

Accession MF_04109
Dates 2-NOV-2016 (Created)
23-AUG-2022 (Last updated, Version 7)
Scope(s) Viruses
Template(s) P03706 (ENLYS_LAMBD); [ Recover all ]
Triggered by HAMAP; MF_04109 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ENLYS
Protein name RecName: Full=Endolysin;
AltName: Full=Transglycosylase;
AltName: Full=Lysozyme;
AltName: Full=Lysis protein;

Comments [?]

FUNCTIONEndolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
CATALYTIC ACTIVITY Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2;
SUBCELLULAR LOCATIONHost cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.
SIMILARITYBelongs to the glycosyl hydrolase 24 family.

Keywords [?]

Gene Ontology [?]

GO:0003796; Molecular function:lysozyme activity
GO:0016829; Molecular function:lyase activity
GO:0044659; Biological process:viral release from host cell by cytolysis
GO:0009253; Biological process:peptidoglycan catabolic process

Cross-references [?]

Pfam PF00959; Phage_lysozyme; 1;

Features [?]

From: ENLYS_LAMBD (P03706)
Key From To Description Tag Condition FTGroup
ACT_SITE 19 19 E

Additional information [?]

Size range 153-181 amino acids
Related rules None
Fusion Nter: None Cter: None

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