HAMAP rule MF_04110
General rule information
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| Accession | MF_04110 |
| Dates | 2-NOV-2016 (Created)
23-AUG-2022 (Last updated, Version 11) |
| Name | ENDOLYSIN_T4 |
| Scope(s) |
Viruses Caudoviricetes |
| Template(s) | P00720 (ENLYS_BPT4); [ Recover all ] |
| Triggered by |
HAMAP; MF_04110 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ENLYS |
| Protein name | RecName: Full=Endolysin; EC=3.2.1.17; AltName: Full=Muramidase; AltName: Full=Lysis protein; AltName: Full=Lysozyme; |
Comments
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| FUNCTION | Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer. |
| CATALYTIC ACTIVITY | Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; |
| SUBCELLULAR LOCATION | Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane. |
| case not <FTTag:Act_site> | |
| CAUTION | Lacks the conserved Asp active site. |
| end case | |
| SIMILARITY | Belongs to the glycosyl hydrolase 24 family. |
Keywords
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| Antimicrobial |
| Bacteriolytic enzyme |
| Cytolysis |
| Glycosidase |
| Host cell lysis by virus |
| Host cytoplasm |
| Hydrolase |
| Viral release from host cell |
Gene Ontology
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| GO:0003796; Molecular function:lysozyme activity |
| GO:0044659; Biological process:viral release from host cell by cytolysis |
| GO:0009253; Biological process:peptidoglycan catabolic process |
Cross-references
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Features
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| From: ENLYS_BPT4 (P00720) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 11 | 11 | /note="Proton donor/acceptor" | E | ||||||||
| ACT_SITE | 20 | 20 | /note="Proton donor/acceptor" | Act_site | [CD] | |||||||
Additional information
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| Size range | 140-380 amino acids |
| Related rules |
MF_04136 |
| Fusion | Nter: None Cter: None |