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HAMAP rule MF_04110

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General rule information [?]

Accession MF_04110
Dates 2-NOV-2016 (Created)
23-AUG-2022 (Last updated, Version 11)
Scope(s) Viruses
Template(s) P00720 (ENLYS_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04110 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ENLYS
Protein name RecName: Full=Endolysin;
AltName: Full=Muramidase;
AltName: Full=Lysis protein;
AltName: Full=Lysozyme;

Comments [?]

FUNCTIONEndolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
CATALYTIC ACTIVITY Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=;
SUBCELLULAR LOCATIONHost cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.
case not <FTTag:Act_site>
CAUTIONLacks the conserved Asp active site.
end case
SIMILARITYBelongs to the glycosyl hydrolase 24 family.

Keywords [?]

Gene Ontology [?]

GO:0003796; Molecular function:lysozyme activity
GO:0044659; Biological process:viral release from host cell by cytolysis
GO:0009253; Biological process:peptidoglycan catabolic process

Cross-references [?]

Pfam PF00959; Phage_lysozyme; 1;

Features [?]

From: ENLYS_BPT4 (P00720)
Key From To Description Tag Condition FTGroup
ACT_SITE 11 11 /note="Proton donor/acceptor" E
ACT_SITE 20 20 /note="Proton donor/acceptor" Act_site [CD]

Additional information [?]

Size range 140-380 amino acids
Related rules MF_04136
Fusion Nter: None Cter: None

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