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HAMAP rule MF_04110

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General rule information [?]

Accession MF_04110
Dates 2-NOV-2016 (Created)
23-AUG-2022 (Last updated, Version 11)
Viruses; Caudoviricetes
Template P00720 (ENLYS_BPT4)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Endolysin;
AltName: Full=Muramidase;
AltName: Full=Lysis protein;
AltName: Full=Lysozyme;

Comments [?]

Function Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
Catalytic activity Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=;
Subcellular location Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.
case not <FTTag:Act_site>
Caution Lacks the conserved Asp active site.
end case
Similarity Belongs to the glycosyl hydrolase 24 family.

Keywords [?]

Gene Ontology [?]

GO:0003796; Molecular function: lysozyme activity.
GO:0044659; Biological process: viral release from host cell by cytolysis.
GO:0009253; Biological process: peptidoglycan catabolic process.

Cross-references [?]

Pfam PF00959; Phage_lysozyme; 1;

Features [?]

From: ENLYS_BPT4 (P00720)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE (Optional)     11     11       Proton donor/acceptor     E  
ACT_SITE (Optional)     20     20       Proton donor/acceptor   Act_site   [CD]  

Additional information [?]

Size range 140-380 amino acids
Related rules MF_04136 (ENLYS supersedes the current rule)
Fusion None