HAMAP rule MF_04110

Accession	MF_04110
Dates	2-NOV-2016 (Created) 23-AUG-2022 (Last updated, Version 11)

Name	ENDOLYSIN_T4

Scope

Viruses; Caudoviricetes

Template

P00720 (ENLYS_BPT4)

Triggered by

HAMAP; MF_04110 (Get profile general information and statistics)

Identifier

ENLYS

Protein name

RecName: Full=Endolysin; EC 3.2.1.17; AltName: Full=Muramidase; AltName: Full=Lysis protein; AltName: Full=Lysozyme;

Function	Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
Catalytic activity	Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;
Subcellular location	Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.

Caution

Lacks the conserved Asp active site.

Similarity

Belongs to the glycosyl hydrolase 24 family.

Antimicrobial
Bacteriolytic enzyme
Cytolysis
Glycosidase
Host cell lysis by virus
Host cytoplasm
Hydrolase
Viral release from host cell

GO:0003796; Molecular function: lysozyme activity.
GO:0044659; Biological process: viral release from host cell by cytolysis.
GO:0009253; Biological process: peptidoglycan catabolic process.

Pfam	PF00959; Phage_lysozyme; 1;
PRINTS	PR00684; T4LYSOZYME; 1;

From: ENLYS_BPT4 (P00720)

Key

From

To

Description

Tag

Condition

FTGroup

ACT_SITE (Optional)

11

11

Proton donor/acceptor

E

ACT_SITE (Optional)

20

20

Proton donor/acceptor

Act_site

[CD]

Size range	140-380 amino acids
Related rules	MF_04136 (ENLYS supersedes the current rule)
Fusion	None

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