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HAMAP rule MF_04129

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General rule information [?]

Accession MF_04129
Dates 28-MAR-2018 (Created)
19-NOV-2022 (Last updated, Version 5)
Name Rota_VP6_A
Scope(s) Viruses
Template(s) P04509 (VP6_ROTRF); A2T3T0 (VP6_ROTSH); P18610 (VP6_ROTBU); Q91N61 (VP6_ROTP5); [ Recover all ]
Triggered by HAMAP; MF_04129 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VP6
Protein name RecName: Full=Intermediate capsid protein VP6;

Comments [?]

FUNCTIONIntermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.
SUBCELLULAR LOCATIONVirion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
SUBUNITHomotrimer. Interacts with the inner capsid protein VP2. Interacts with the outer capsid glycoprotein VP7. Interacts with the outer capsid protein VP5*.
PTMThe N-terminus is blocked.
PTMSumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins seems to have a positive role on viral replication.
MISCELLANEOUSThe VP6 trimer contains a zinc ion located at the center of the molecule. The zinc ion is not essential for either trimerization or transcription activity of the DLP. Zinc-depleted VP6 has an increased sensitivity to proteases.
SIMILARITYBelongs to the rotavirus VP6 family.

Keywords [?]

Gene Ontology [?]

GO:0019031; Cellular component:viral envelope
GO:0039626; Cellular component:viral intermediate capsid
GO:0046789; Molecular function:host cell surface receptor binding
GO:0005198; Molecular function:structural molecule activity
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane
GO:0046872; Molecular function:metal ion binding

Cross-references [?]

Pfam PF00980; Rota_Capsid_VP6; 1;

Features [?]

From: VP6_ROTRF (P04509)
Key From To Description Tag Condition FTGroup
BINDING 153 153 /ligand="Zn(2+)"
/ligand_note="ligand shared between all trimeric partners"
BINDING 266 266 /ligand="Ca(2+)"
BINDING 286 286 /ligand="Ca(2+)"
From: VP6_ROTSH (P04509)
Key From To Description Tag Condition FTGroup
REGION 62 73 /note="Interaction with the inner capsid protein VP2"

Additional information [?]

Size range 390-400 amino acids
Related rules MF_04126
Fusion Nter: None Cter: None

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