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HAMAP rule MF_04130

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General rule information [?]

Accession MF_04130
Dates 28-MAR-2018 (Created)
20-NOV-2019 (Last updated, Version 3)
Name Rota_VP7
Scope(s) Viruses
Template(s) A2T3P5 (VP7_ROTSH); P12476 (VP7_ROTRH); Q86515 (VP7_ROTRF); [ Recover all ]
Triggered by HAMAP; MF_04130 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VP7
Protein name RecName: Full=Outer capsid glycoprotein VP7;

Comments [?]

FUNCTIONCalcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
SUBUNITHomotrimer; disulfide-linked. 2 Ca(2+) ions bound at each subunit interface in the trimer hold the trimer together. Interacts with the intermediate capsid protein VP6. Interacts with the outer capsid protein VP5*.
SUBCELLULAR LOCATIONVirion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
SIMILARITYBelongs to the rotavirus VP7 family.

Keywords [?]

Gene Ontology [?]

GO:0044166; Cellular component:host cell endoplasmic reticulum lumen
GO:0039621; Cellular component:T=13 icosahedral viral capsid
GO:0039624; Cellular component:viral outer capsid

Cross-references [?]

Pfam PF00434; VP7; 1;
General Signal; -; 1;

Features [?]

Additional information [?]

Size range 240-340 amino acids
Related rules None
Fusion Nter: None Cter: None

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