HAMAP rule MF_04130

Accession	MF_04130
Dates	28-MAR-2018 (Created) 20-NOV-2019 (Last updated, Version 3)

Name

Rota_VP7

Scope

Viruses; Rotavirus

Templates

A2T3P5 (VP7_ROTSH); P12476 (VP7_ROTRH); Q86515 (VP7_ROTRF): [Recover all]

Triggered by

HAMAP; MF_04130 (Get profile general information and statistics)

Identifier

VP7

Protein name

RecName: Full=Outer capsid glycoprotein VP7;

Function	Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
Subunit	Homotrimer; disulfide-linked. 2 Ca(2+) ions bound at each subunit interface in the trimer hold the trimer together. Interacts with the intermediate capsid protein VP6. Interacts with the outer capsid protein VP5*.
Subcellular location	Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Similarity	Belongs to the rotavirus VP7 family.

Calcium
Capsid protein
Disulfide bond
Glycoprotein
Host endoplasmic reticulum
Host-virus interaction
Metal-binding
Outer capsid protein
T=13 icosahedral capsid protein
Virion

GO:0044166; Cellular component: host cell endoplasmic reticulum lumen.
GO:0039621; Cellular component: T=13 icosahedral viral capsid.
GO:0039624; Cellular component: viral outer capsid.

Pfam	PF00434; VP7; 1;

General

Signal; -; 1; trigger=yes;

Size range	240-340 amino acids
Related rules	None
Fusion	None

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