HAMAP rule MF_04135
General rule information
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| Accession | MF_04135 |
| Dates | 11-JAN-2019 (Created)
1-MAR-2024 (Last updated, Version 8) |
| Name | PORTAL_LAMBDA |
| Scope(s) |
Viruses Caudoviricetes |
| Template(s) | P03710 (PORTL_LAMBD); [ Recover all ] |
| Triggered by |
HAMAP; MF_04135 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PORTL |
| case <OC:Lambdavirus> | |
| Protein name | RecName: Full=Portal protein B; AltName: Full=GpB; AltName: Full=Minor capsid protein B; |
| else | |
| Protein name | RecName: Full=Portal protein; |
| end case | |
| case <FTTag:cleavage> | |
| Protein name | Contains: RecName: Full=Protein B*; |
| end case | |
| case <OC:Lambdavirus> | |
| Gene name | Name=B; |
| end case | |
Comments
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| FUNCTION | Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine. |
| SUBUNIT | Homododecamer. Interacts with the terminase complex composed of two small and one large terminase subunits. |
| SUBCELLULAR LOCATION | Virion. |
| PTM | Proteolytically cleaved by the viral protease during capsid maturation. |
| SIMILARITY | Belongs to the siphoviridae portal protein family. |
Keywords
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| Capsid protein | |
| DNA-binding | |
| Viral capsid assembly | |
| Viral genome ejection through host cell envelope | |
| Viral genome packaging | |
| case <OC:Lambdavirus> | |
| Viral long flexible tail ejection system | |
| end case | |
| case <OC:Tevenvirinae> | |
| Viral contractile tail ejection system | |
| end case | |
| case <OC:Teseptimavirus> | |
| Viral short tail ejection system | |
| end case | |
| Viral penetration into host cytoplasm | |
| Viral release from host cell | |
| Virion | |
| Virus entry into host cell | |
Gene Ontology
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| GO:0046798; Cellular component:viral portal complex | |
| GO:0005198; Molecular function:structural molecule activity | |
| case <OCellular component:Lambdavirus> | |
| GO:0099001; Biological process:symbiont genome ejection through host cell envelope, long flexible tail mechanism | |
| end case | |
| GO:0019068; Biological process:virion assembly | |
Cross-references
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| Pfam | PF05136; Phage_portal_2; 1; |
| NCBIfam | TIGR01539; portal_lambda; 1; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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| From: PORTL_LAMBD (P03710) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Lambdavirus> | ||||||||||||
| CHAIN | Nter | Cter | /note="Portal protein B" | |||||||||
| else | ||||||||||||
| CHAIN | Nter | Cter | /note="Portal protein" | |||||||||
| end case | ||||||||||||
| SITE | 22 | 23 | /note="Cleavage; by viral protease" | cleavage | [GA]-G | |||||||
| case <FTTag:cleavage> | ||||||||||||
| CHAIN | 23 | Cter | /note="Protein B*" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 490-590 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |