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HAMAP rule MF_04137

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General rule information [?]

Accession MF_04137
Dates 16-APR-2019 (Created)
29-SEP-2022 (Last updated, Version 9)
Scope(s) Viruses
Template(s) P27358 (SPAN1_BPP21); [ Recover all ]
Triggered by HAMAP; MF_04137 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SPAN1
Protein name RecName: Full=Spanin, inner membrane subunit;
AltName: Full=Lysis protein Rz;

Comments [?]

FUNCTIONComponent of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans. Host outer membrane disruption is due to local fusion between the inner and outer membrane performed by the spanin complex.
case <FTGroup:1>
SUBUNITHomodimer; disulfide-linked. Interacts (via C-terminus) with the spanin outer lipoprotein subunit (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of one homodimer of the i-spanin linked by intermolecular disulfide bonds involving two Cys residues and one homodimer of the o-spanin covalently linked by an intermolecular disulfide bond involving one Cys.
end case
case <AnyFeature:Transmembrane<2>
SUBCELLULAR LOCATIONHost cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
end case
case <Feature:Coiled_coil>
DOMAINThe coiled coil region is probably involved in host membrane fusion leading to lysis.
end case
SIMILARITYBelongs to the Lambdavirus i-spanin family.

Keywords [?]

Gene Ontology [?]

GO:0020002; Cellular component:host cell plasma membrane
GO:0016020; Cellular component:membrane
GO:0044659; Biological process:viral release from host cell by cytolysis

Cross-references [?]

Pfam PF03245; Phage_lysis; 1;
General Coiled_coil; -; 0-unlimited;
ADD_TOPO_DOMAIN Cytoplasmic; -; 1;
ADD_TOPO_DOMAIN Periplasmic; -; 1;
General Transmembrane; -; 0-1;

Features [?]

From: SPAN1_LAMBD (P00726)
Key From To Description Tag Condition FTGroup
DISULFID 99 99 /note="Interchain" C 1
DISULFID 152 152 /note="Interchain" C 1
case not <Feature:Transmembrane==1>
TOPO_DOM Nter 3 /note="Cytoplasmic"
TRANSMEM 4 24 /note="Helical; Signal-anchor for type II membrane protein"
TOPO_DOM 25 Cter /note="Periplasmic"
end case

Additional information [?]

Size range 95-195 amino acids
Related rules None
Fusion Nter: None Cter: None

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