HAMAP rule MF_04137
General rule information
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Accession | MF_04137 |
Dates | 16-APR-2019 (Created)
29-SEP-2022 (Last updated, Version 9) |
Name | I-SPANIN_LAMBDA |
Scope(s) |
Viruses |
Template(s) | P27358 (SPAN1_BPP21); [ Recover all ] |
Triggered by |
HAMAP; MF_04137 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | SPAN1 |
Protein name | RecName: Full=Spanin, inner membrane subunit; Short=i-spanin; AltName: Full=Lysis protein Rz; |
Comments
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FUNCTION | Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans. Host outer membrane disruption is due to local fusion between the inner and outer membrane performed by the spanin complex. |
case <FTGroup:1> | |
SUBUNIT | Homodimer; disulfide-linked. Interacts (via C-terminus) with the spanin outer lipoprotein subunit (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of one homodimer of the i-spanin linked by intermolecular disulfide bonds involving two Cys residues and one homodimer of the o-spanin covalently linked by an intermolecular disulfide bond involving one Cys. |
end case | |
case <AnyFeature:Transmembrane<2> | |
SUBCELLULAR LOCATION | Host cell inner membrane; Single-pass type II membrane protein; Periplasmic side. |
end case | |
case <Feature:Coiled_coil> | |
DOMAIN | The coiled coil region is probably involved in host membrane fusion leading to lysis. |
end case | |
SIMILARITY | Belongs to the Lambdavirus i-spanin family. |
Keywords
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case <Feature:coiled> | |
Coiled coil | |
end case | |
Cytolysis | |
case <FTGroup:1> | |
Disulfide bond | |
end case | |
case <Feature:Transmembrane> | |
Signal-anchor | |
Transmembrane | |
Transmembrane helix | |
Host cell inner membrane | |
Host cell membrane | |
Host membrane | |
Membrane | |
end case | |
Host cell lysis by virus | |
Viral release from host cell |
Gene Ontology
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GO:0020002; Cellular component:host cell plasma membrane |
GO:0016020; Cellular component:membrane |
GO:0044659; Biological process:viral release from host cell by cytolysis |
Cross-references
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Pfam | PF03245; Phage_lysis; 1; |
General | Coiled_coil; -; 0-unlimited; |
ADD_TOPO_DOMAIN | Cytoplasmic; -; 1; |
ADD_TOPO_DOMAIN | Periplasmic; -; 1; |
General | Transmembrane; -; 0-1; |
Features
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From: SPAN1_LAMBD (P00726) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DISULFID | 99 | 99 | /note="Interchain" | C | 1 | |||||||
DISULFID | 152 | 152 | /note="Interchain" | C | 1 | |||||||
case not <Feature:Transmembrane==1> | ||||||||||||
TOPO_DOM | Nter | 3 | /note="Cytoplasmic" | |||||||||
TRANSMEM | 4 | 24 | /note="Helical; Signal-anchor for type II membrane protein" | |||||||||
TOPO_DOM | 25 | Cter | /note="Periplasmic" | |||||||||
end case |
Additional information
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Size range | 95-195 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |