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Annotation rule MF_04139 |
Accession | MF_04139 |
Dates | 21-MAY-2019 (Created) 20-NOV-2019 (Last updated, Version 4) |
Name | ALT_T4 |
Scope | Viruses |
Template | P12726 (ALT_BPT4) |
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Function | ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction. |
Catalytic activity | RHEA:19149: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
EC 2.4.2.31 PhysiologicalDirection=left-to-right (RHEA:19150) |
Subcellular location | Virion. Note=About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA. |
Similarity | Belongs to the Tevenvirinae NAD(+)--arginine ADP-ribosyltransferase family. |
Pfam | PF03496; ADPrib_exo_Tox; 1; |
PIRSF | PIRSF000491; Alt_phage; 1; |
General | Coiled_coil; -; 0-unlimited; trigger=yes; |
From: ALT_BPT4 (P12726) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
SITE (Optional) | 6 | 7 | Cleavage | Propep | E-[ILSV] |
Size range | 600-750 amino acids |
Related rules | None |
Fusion | None |