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HAMAP rule MF_04139

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General rule information [?]

Accession MF_04139
Dates 21-MAY-2019 (Created)
17-MAY-2022 (Last updated, Version 8)
Name ALT_T4
Scope(s) Viruses
Template(s) P12726 (ALT_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04139 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ALT
case <OC:Tevenvirinae>
Protein name RecName: Full=NAD(+)--arginine ADP-ribosyltransferase;
AltName: Full=Alt protein;
                 Flags: Precursor;
Gene name Name=alt;
Protein name RecName: Full=NAD(+)--arginine ADP-ribosyltransferase;
end case
case <FTTag:Propep>
Protein name Flags: Precursor;
end case

Comments [?]

FUNCTIONADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction.
case <FTTag:Act_site>
CATALYTIC ACTIVITY Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19150;
end case
SUBCELLULAR LOCATIONVirion. Note=About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA.
SIMILARITYBelongs to the Tevenvirinae NAD(+)--arginine ADP- ribosyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0044423; Cellular component:virion component
GO:0106274; Molecular function:NAD+-protein-arginine ADP-ribosyltransferase activity
GO:0046782; Biological process:regulation of viral transcription

Cross-references [?]

Pfam PF03496; ADPrib_exo_Tox; 1;
PIRSF PIRSF000491; Alt_phage; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

From: ALT_BPT4 (P12726)
Key From To Description Tag Condition FTGroup
SITE 6 7 /note="Cleavage" Propep E-[ILSV]
case <FTTag:Propep>
CHAIN 7 Cter /note="NAD(+)--arginine ADP-ribosyltransferase"
CHAIN Nter Cter /note="NAD(+)--arginine ADP-ribosyltransferase"
end case
ACT_SITE 576 576 Act_site E

Additional information [?]

Size range 600-750 amino acids
Related rules None
Fusion Nter: None Cter: None

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