HAMAP rule MF_04139
General rule information
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Accession | MF_04139 |
Dates | 21-MAY-2019 (Created) 17-MAY-2022 (Last updated, Version 8) |
Name | ALT_T4 |
Scope | Viruses |
Template | P12726 (ALT_BPT4) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Tevenvirinae>
Protein name |
|
Gene name |
|
else
Protein name |
|
end case
case <FTTag:Propep>
Protein name |
|
end case
Comments
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Function | ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction. |
case <FTTag:Act_site>
Catalytic activity | RHEA:19149: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
EC 2.4.2.31 PhysiologicalDirection=left-to-right (RHEA:19150) |
end case
Subcellular location | Virion. Note=About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA. |
Similarity | Belongs to the Tevenvirinae NAD(+)--arginine ADP-ribosyltransferase family. |
Keywords
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Gene Ontology
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GO:0044423; Cellular component: virion component.
GO:0106274; Molecular function: NAD+-protein-arginine ADP-ribosyltransferase activity.
GO:0046782; Biological process: regulation of viral transcription.
GO:0106274; Molecular function: NAD+-protein-arginine ADP-ribosyltransferase activity.
GO:0046782; Biological process: regulation of viral transcription.
Cross-references
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Pfam | PF03496; ADPrib_exo_Tox; 1; |
PIRSF | PIRSF000491; Alt_phage; 1; |
PROSITE | PS51996; TR_MART; 1; trigger=PRU01340; |
Computed features
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General | Coiled_coil; -; 0-unlimited; trigger=yes; |
Features
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From: ALT_BPT4 (P12726) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
SITE (Optional) | 6 | 7 | Cleavage | Propep | E-[ILSV] |
case <FTTag:Propep>
else
end case
Additional information
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Size range | 600-750 amino acids |
Related rules | None |
Fusion | None |