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HAMAP rule MF_04139

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General rule information [?]

Accession MF_04139
Dates 21-MAY-2019 (Created)
17-MAY-2022 (Last updated, Version 8)
Name ALT_T4
Scope
Viruses
Template P12726 (ALT_BPT4)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ALT
case <OC:Tevenvirinae>
Protein name
RecName: Full=NAD(+)--arginine ADP-ribosyltransferase;
EC 2.4.2.31;
AltName: Full=Alt protein;
Flags: Precursor;
Gene name
alt
else
Protein name
RecName: Full=NAD(+)--arginine ADP-ribosyltransferase;
EC 2.4.2.31;
end case
case <FTTag:Propep>
Protein name
Flags: Precursor;
end case

Comments [?]

Function ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction.
case <FTTag:Act_site>
Catalytic activity RHEA:19149: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
EC 2.4.2.31
PhysiologicalDirection=left-to-right (RHEA:19150)
end case
Subcellular location Virion. Note=About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA.
Similarity Belongs to the Tevenvirinae NAD(+)--arginine ADP-ribosyltransferase family.

Keywords [?]

Glycosyltransferase
NAD
Nucleotidyltransferase
Transferase
Virion

Gene Ontology [?]

GO:0044423; Cellular component: virion component.
GO:0106274; Molecular function: NAD+-protein-arginine ADP-ribosyltransferase activity.
GO:0046782; Biological process: regulation of viral transcription.

Cross-references [?]

Pfam PF03496; ADPrib_exo_Tox; 1;
PIRSF PIRSF000491; Alt_phage; 1;
PROSITE PS51996; TR_MART; 1; trigger=PRU01340;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Features [?]

From: ALT_BPT4 (P12726)
Key     From     To       Description   Tag   Condition   FTGroup
SITE (Optional)     6     7       Cleavage   Propep   E-[ILSV]  
case <FTTag:Propep>
PROPEP     Nter     6                
CHAIN     7     Cter       NAD(+)--arginine ADP-ribosyltransferase        
else
CHAIN     Nter     Cter       NAD(+)--arginine ADP-ribosyltransferase        
end case
ACT_SITE     576     576           Act_site   E  

Additional information [?]

Size range 600-750 amino acids
Related rules None
Fusion None


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