HAMAP rule MF_04139
General rule information
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| Accession | MF_04139 |
| Dates | 21-MAY-2019 (Created)
2-SEP-2024 (Last updated, Version 13) |
| Name | ALT_T4 |
| Scope(s) |
Viruses |
| Template(s) | P12726 (ALT_BPT4); [ Recover all ] |
| Triggered by |
HAMAP; MF_04139 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ALT |
| case <FTTag:cleavage1> and <FTTag:cleavage2> | |
| Protein name | RecName: Full=NAD(+)--arginine ADP-ribosyltransferase; EC=2.4.2.31; Contains: RecName: Full=Mature NAD(+)--arginine ADP-ribosyltransferase; |
| else | |
| Protein name | RecName: Full=NAD(+)--arginine ADP-ribosyltransferase; EC=2.4.2.31; |
| end case | |
Comments
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| FUNCTION | ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction. |
| SUBCELLULAR LOCATION | Virion. Note=About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA. |
| SIMILARITY | Belongs to the Tevenvirinae NAD(+)--arginine ADP- ribosyltransferase family. |
| case <FTTag:Act_site> | |
| CATALYTIC ACTIVITY | Reaction=L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L- arginyl-[protein] + nicotinamide + H(+); Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19150; |
| end case | |
| case <FTTag:cleavage1> and <FTTag:cleavage2> | |
| PTM | Proteolytic cleavages at the N- and C-termini by the prohead core protein protease give rise to the mature enzyme. |
| end case | |
Keywords
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Gene Ontology
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| GO:0044423; Cellular component:virion component |
| GO:0106274; Molecular function:NAD+-protein-arginine ADP-ribosyltransferase activity |
| GO:0046782; Biological process:regulation of viral transcription |
Cross-references
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| Pfam | PF03496; ADPrib_exo_Tox; 1; |
| PIRSF | PIRSF000491; Alt_phage; 1; |
| General | Coiled_coil; -; 0-unlimited; |
| PROSITE | PS51996; TR_MART; 1; |
Features
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| From: ALT_BPT4 (P12726) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| CHAIN | Nter | Cter | /note="NAD(+)--arginine ADP-ribosyltransferase" | |||||||||
| SITE | 6 | 7 | /note="Cleavage" | cleavage1 | E-[LVS] | |||||||
| SITE | 619 | 620 | /note="Cleavage" | cleavage2 | E-S | |||||||
| case <FTTag:cleavage1> and <FTTag:cleavage2> | ||||||||||||
| CHAIN | 7 | 619 | /note="Mature NAD(+)--arginine ADP-ribosyltransferase" | |||||||||
| end case | ||||||||||||
| ACT_SITE | 576 | 576 | Act_site | E | ||||||||
Additional information
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| Size range | 600-750 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |