HAMAP rule MF_04141
General rule information
[?]
Accession |
MF_04141 |
Dates |
8-OCT-2019 (Created) 19-NOV-2022 (Last updated, Version 9) |
Scope |
Viruses; Tevenvirinae |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=NAD--protein ADP-ribosyltransferase modA;
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EC 2.4.2.31;
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AltName:
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Full=RNA polymerase ADP-ribosylase modA;
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Function |
ADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP-ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters. |
Catalytic activity |
RHEA:19149: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
EC 2.4.2.31
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Subcellular location |
Virion. Note=This protein is injected from the virion into the bacterial cell. |
Similarity |
Belongs to the Tevenvirinae NAD--protein ADP-ribosyltransferase modA family. |
GO:0106274; Molecular function: NAD+-protein-arginine ADP-ribosyltransferase activity.
GO:0044423; Cellular component: virion component.
From: MODA_BPT4 (P39421) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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165
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165
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E
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BINDING
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72
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72
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/ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540
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R
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Additional information
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Size range |
190-210 amino acids |
Related rules |
None |
Fusion |
None |