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HAMAP rule MF_04141

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General rule information [?]

Accession MF_04141
Dates 8-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 9)
Name MODA_T4
Scope(s) Viruses
Template(s) P39421 (MODA_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04141 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MODA
Protein name RecName: Full=NAD--protein ADP-ribosyltransferase modA;
AltName: Full=RNA polymerase ADP-ribosylase modA;
Gene name Name=modA;

Comments [?]

FUNCTIONADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP- ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters.
CATALYTIC ACTIVITY Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=;
SUBCELLULAR LOCATIONVirion. Note=This protein is injected from the virion into the bacterial cell.
SIMILARITYBelongs to the Tevenvirinae NAD--protein ADP- ribosyltransferase modA family.

Keywords [?]

Gene Ontology [?]

GO:0106274; Molecular function:NAD+-protein-arginine ADP-ribosyltransferase activity
GO:0044423; Cellular component:virion component

Cross-references [?]

Features [?]

From: MODA_BPT4 (P39421)
Key From To Description Tag Condition FTGroup
ACT_SITE 165 165 E
BINDING 72 72 /ligand="NAD(+)"

Additional information [?]

Size range 190-210 amino acids
Related rules None
Fusion Nter: None Cter: None

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