HAMAP rule MF_04141
General rule information
[?]
Accession | MF_04141 |
Dates | 8-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 9) |
Name | MODA_T4 |
Scope(s) |
Viruses Tevenvirinae |
Template(s) | P39421 (MODA_BPT4); [ Recover all ] |
Triggered by |
HAMAP; MF_04141 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | MODA |
Protein name | RecName: Full=NAD--protein ADP-ribosyltransferase modA; EC=2.4.2.31; AltName: Full=RNA polymerase ADP-ribosylase modA; |
Gene name | Name=modA; |
Comments
[?]
FUNCTION | ADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP- ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters. |
CATALYTIC ACTIVITY | Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D- ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; |
SUBCELLULAR LOCATION | Virion. Note=This protein is injected from the virion into the bacterial cell. |
SIMILARITY | Belongs to the Tevenvirinae NAD--protein ADP- ribosyltransferase modA family. |
Keywords
[?]
Gene Ontology
[?]
GO:0106274; Molecular function:NAD+-protein-arginine ADP-ribosyltransferase activity |
GO:0044423; Cellular component:virion component |
Cross-references
[?]
Features
[?]
From: MODA_BPT4 (P39421) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 165 | 165 | E | |||||||||
BINDING | 72 | 72 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R |
Additional information
[?]
Size range | 190-210 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |