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HAMAP rule MF_04141

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General rule information [?]

Accession MF_04141
Dates 8-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 9)
Name MODA_T4
Viruses; Tevenvirinae
Template P39421 (MODA_BPT4)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=NAD--protein ADP-ribosyltransferase modA;
AltName: Full=RNA polymerase ADP-ribosylase modA;
Gene name

Comments [?]

Function ADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP-ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters.
Catalytic activity RHEA:19149: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
Subcellular location Virion. Note=This protein is injected from the virion into the bacterial cell.
Similarity Belongs to the Tevenvirinae NAD--protein ADP-ribosyltransferase modA family.

Keywords [?]

Gene Ontology [?]

GO:0106274; Molecular function: NAD+-protein-arginine ADP-ribosyltransferase activity.
GO:0044423; Cellular component: virion component.

Features [?]

From: MODA_BPT4 (P39421)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     165     165             E  
BINDING     72     72       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     R  

Additional information [?]

Size range 190-210 amino acids
Related rules None
Fusion None