HAMAP rule MF_04141

General rule information [?]

Accession	MF_04141
Dates	8-OCT-2019 (Created) 19-NOV-2022 (Last updated, Version 9)

Name

MODA_T4

Scope

Viruses; Tevenvirinae

Template

P39421 (MODA_BPT4)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MODA

Protein name

RecName:		Full=NAD--protein ADP-ribosyltransferase modA;
		EC 2.4.2.31;
AltName:		Full=RNA polymerase ADP-ribosylase modA;

Gene name

modA

Comments [?]

Function	ADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP-ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters.
Catalytic activity	RHEA:19149: L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide EC 2.4.2.31
Subcellular location	Virion. Note=This protein is injected from the virion into the bacterial cell.
Similarity	Belongs to the Tevenvirinae NAD--protein ADP-ribosyltransferase modA family.

Keywords [?]

Gene Ontology [?]

GO:0106274; Molecular function: NAD+-protein-arginine ADP-ribosyltransferase activity.
GO:0044423; Cellular component: virion component.

Features [?]

From: MODA_BPT4 (P39421)

Key From To Description Tag Condition FTGroup

ACT_SITE 165 165 E

BINDING 72 72 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 R

Additional information [?]