HAMAP rule MF_04141
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_04141 |
| Accession | MF_04141 |
| Dates | 8-OCT-2019 (Created)
2-SEP-2024 (Last updated, Version 10) |
| Name | MODA_T4 |
| Scope(s) |
Viruses Tevenvirinae |
| Template(s) | P39421 (MODA_BPT4); [ Recover all ] |
| Triggered by |
HAMAP; MF_04141 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MODA |
| Protein name | RecName: Full=NAD--protein ADP-ribosyltransferase modA; EC=2.4.2.31; AltName: Full=RNA polymerase ADP-ribosylase modA; |
| Gene name | Name=modA; |
Comments
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| FUNCTION | ADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP- ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters. |
| CATALYTIC ACTIVITY | Reaction=L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L- arginyl-[protein] + nicotinamide + H(+); Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; |
| SUBCELLULAR LOCATION | Virion. Note=This protein is injected from the virion into the bacterial cell. |
| SIMILARITY | Belongs to the Tevenvirinae NAD--protein ADP- ribosyltransferase modA family. |
Keywords
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Gene Ontology
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| GO:0106274; Molecular function:NAD+-protein-arginine ADP-ribosyltransferase activity |
| GO:0044423; Cellular component:virion component |
Cross-references
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Features
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| From: MODA_BPT4 (P39421) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 165 | 165 | E | |||||||||
| BINDING | 72 | 72 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
Additional information
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| Size range | 190-210 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |