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Annotation rule MF_04143 |
General rule information
[?]
Accession |
MF_04143 |
Dates |
12-DEC-2019 (Created) 3-FEB-2020 (Last updated, Version 5) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <Feature:PF17057>
else
end case
case <OC:Poxviridae>
Function |
Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses. |
else case <OC:Viruses>
Function |
Nuclease that cleaves host 2',3'-cGAMP. |
end case
case <OC:Insecta>
Function |
Nuclease that cleaves 2',3'-cGAMP. |
end case
Catalytic activity |
RHEA:59472: 2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)
PhysiologicalDirection=left-to-right
(RHEA:59473)
|
case <OC:Viruses>
Subunit |
Homodimer. |
Domain |
The substrate binding site is formed by the N-terminus of a monomer and the C-terminus of the opposite monomer. |
end case
case <Feature:PF17057>
Similarity |
In the N-terminal section; belongs to the poxin family. |
|
In the C-terminal section; belongs to the Schlafen protein family. Subgroup poxviridae B3 subfamily. |
else case <OC:Viruses>
Similarity |
Belongs to the poxin family. |
else case <OC:Insecta>
Similarity |
Belongs to the poxin family. Highly divergent. |
Caution |
The active site cannot be determined by similarity to the viral poxins. |
end case
GO:0061507; Molecular function: cyclic-GMP-AMP binding.
GO:0004518; Molecular function: nuclease activity.
case <OC:Poxviridae>
GO:0039503; Biological process: suppression by virus of host innate immune response.
end case
case <OC:Viruses>
From: POXIN_VACCW (Q01225) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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17
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17
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Proton donor
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H
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ACT_SITE
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138
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138
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Shared with catalytic histidine of dimeric partner
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Y
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ACT_SITE
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142
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142
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Proton acceptor; shared with catalytic histidine of dimeric partner
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|
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K
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SITE
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60
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60
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Substrate binding
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R
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SITE
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105
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105
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Substrate binding
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I
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SITE
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149
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149
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Substrate binding
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|
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N
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|
SITE
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169
|
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169
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Substrate binding
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Q
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SITE
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182
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182
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Substrate binding
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R
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SITE
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184
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184
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Substrate binding
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R
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SITE
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186
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186
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Substrate binding
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K
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end case
case <Feature:PF17057>
From: POXIN_CWPXB (Q8QMP8) |
REGION
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Nter
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238
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Poxin-like
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REGION
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239
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Cter
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Schlafen-like
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end case
Additional information
[?]
Size range |
180-550 amino acids |
Related rules |
None |
Fusion |
None |