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HAMAP rule MF_04153

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General rule information [?]

Accession MF_04153
Dates 17-JAN-2021 (Created)
25-FEB-2021 (Last updated, Version 3)
Name SSB_T7
Scope
Viruses
Template P03696 (SSB_BPT7)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SSB
case <OC:Teseptimavirus>
Protein name
RecName: Full=Single-stranded DNA-binding protein;
Short=SSB protein;
AltName: Full=2.5 protein;
AltName: Full=Gene product 2.5;
Short=gp2.5;
else
Protein name
RecName: Full=Single-stranded DNA-binding protein;
Short=SSB protein;
AltName: Full=Helix-destabilizing protein;
end case

Comments [?]

Function Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions and mediates homologous DNA strand exchange. Promotes also the formation of joint molecules. Disrupts loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.
case <OC:Teseptimavirus>
Subunit Homodimer. Interacts (via C-terminus) with the viral DNA polymerase. Interacts with the viral helicase/primase. Part of the replicase complex that includes the DNA polymerase, host thioredoxin, the primase/helicase and the single-stranded DNA binding protein.
else
Subunit Homodimer. Interacts (via C-terminus) with the viral DNA polymerase. Interacts with the viral helicase/primase. Part of the replicase complex that includes the DNA polymerase, the primase/helicase and the single-stranded DNA binding protein.
end case
Domain The acidic C-terminus is involved in modulating the ssDNA binding properties. It is also required for dimer formation and for interactions with the viral DNA polymerase and the helicase.
Similarity Belongs to the Teseptimavirus single-stranded DNA-binding protein family.

Keywords [?]

DNA recombination
DNA repair
DNA-binding
Viral DNA replication

Gene Ontology [?]

GO:0003697; Molecular function: single-stranded DNA binding.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0039693; Biological process: viral DNA genome replication.

Features [?]

From: SSB_BPT7 (P03696)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     212     232       Dimerization and interaction with the viral DNA polymerase and helicase        

Additional information [?]

Size range 210-260 amino acids
Related rules None
Fusion None


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