HAMAP rule MF_04153
General rule information
[?]
| Accession | MF_04153 |
| Dates | 17-JAN-2021 (Created)
25-FEB-2021 (Last updated, Version 3) |
| Name | SSB_T7 |
| Scope(s) |
Viruses |
| Template(s) | P03696 (SSB_BPT7); [ Recover all ] |
| Triggered by |
HAMAP; MF_04153 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | SSB |
| case <OC:Teseptimavirus> | |
| Protein name | RecName: Full=Single-stranded DNA-binding protein; Short=SSB protein; AltName: Full=2.5 protein; AltName: Full=Gene product 2.5; Short=gp2.5; |
| else | |
| Protein name | RecName: Full=Single-stranded DNA-binding protein; Short=SSB protein; AltName: Full=Helix-destabilizing protein; |
| end case | |
Comments
[?]
| FUNCTION | Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions and mediates homologous DNA strand exchange. Promotes also the formation of joint molecules. Disrupts loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. |
| case <OC:Teseptimavirus> | |
| SUBUNIT | Homodimer. Interacts (via C-terminus) with the viral DNA polymerase. Interacts with the viral helicase/primase. Part of the replicase complex that includes the DNA polymerase, host thioredoxin, the primase/helicase and the single-stranded DNA binding protein. |
| else | |
| SUBUNIT | Homodimer. Interacts (via C-terminus) with the viral DNA polymerase. Interacts with the viral helicase/primase. Part of the replicase complex that includes the DNA polymerase, the primase/helicase and the single-stranded DNA binding protein. |
| end case | |
| DOMAIN | The acidic C-terminus is involved in modulating the ssDNA binding properties. It is also required for dimer formation and for interactions with the viral DNA polymerase and the helicase. |
| SIMILARITY | Belongs to the Teseptimavirus single-stranded DNA-binding protein family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0003697; Molecular function:single-stranded DNA binding |
| GO:0006310; Biological process:DNA recombination |
| GO:0006281; Biological process:DNA repair |
| GO:0039693; Biological process:viral DNA genome replication |
Cross-references
[?]
Features
[?]
| From: SSB_BPT7 (P03696) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 212 | 232 | /note="Dimerization and interaction with the viral DNA polymerase and helicase" | |||||||||
| polymerase and helicase" | ||||||||||||
Additional information
[?]
| Size range | 210-260 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |