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HAMAP rule MF_04153

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General rule information [?]

Accession MF_04153
Dates 17-JAN-2021 (Created)
25-FEB-2021 (Last updated, Version 3)
Name SSB_T7
Scope(s) Viruses
Template(s) P03696 (SSB_BPT7); [ Recover all ]
Triggered by HAMAP; MF_04153 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SSB
case <OC:Teseptimavirus>
Protein name RecName: Full=Single-stranded DNA-binding protein;
                 Short=SSB protein;
AltName: Full=2.5 protein;
AltName: Full=Gene product 2.5;
                 Short=gp2.5;
else
Protein name RecName: Full=Single-stranded DNA-binding protein;
                 Short=SSB protein;
AltName: Full=Helix-destabilizing protein;
end case

Comments [?]

FUNCTIONSingle-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions and mediates homologous DNA strand exchange. Promotes also the formation of joint molecules. Disrupts loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.
case <OC:Teseptimavirus>
SUBUNITHomodimer. Interacts (via C-terminus) with the viral DNA polymerase. Interacts with the viral helicase/primase. Part of the replicase complex that includes the DNA polymerase, host thioredoxin, the primase/helicase and the single-stranded DNA binding protein.
else
SUBUNITHomodimer. Interacts (via C-terminus) with the viral DNA polymerase. Interacts with the viral helicase/primase. Part of the replicase complex that includes the DNA polymerase, the primase/helicase and the single-stranded DNA binding protein.
end case
DOMAINThe acidic C-terminus is involved in modulating the ssDNA binding properties. It is also required for dimer formation and for interactions with the viral DNA polymerase and the helicase.
SIMILARITYBelongs to the Teseptimavirus single-stranded DNA-binding protein family.

Keywords [?]


Gene Ontology [?]

GO:0003697; Molecular function:single-stranded DNA binding
GO:0006310; Biological process:DNA recombination
GO:0006281; Biological process:DNA repair
GO:0039693; Biological process:viral DNA genome replication

Cross-references [?]


Features [?]

From: SSB_BPT7 (P03696)
Key From To Description Tag Condition FTGroup
REGION 212 232 /note="Dimerization and interaction with the viral DNA polymerase and helicase"
polymerase and helicase"

Additional information [?]

Size range 210-260 amino acids
Related rules None
Fusion Nter: None Cter: None



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