HAMAP rule MF_04155

General rule information [?]

Accession	MF_04155
Dates	8-FEB-2021 (Created) 19-NOV-2022 (Last updated, Version 6)

Name

Helic_T4

Scope

Viruses

Template

P04530 (HELIC_BPT4)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HELIC

case <OC:Tequatrovirus>

Protein name

RecName:		Full=DnaB-like replicative helicase;
		EC 3.6.4.-;
AltName:		Full=Gene product 41;
		Short=Gp41;

Gene name

else

Protein name

RecName:		Full=DnaB-like replicative helicase;
		EC 3.6.4.-;

end case

Comments [?]

Function	ATP-dependent DNA helicase essential for viral DNA replication and recombination. The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis. Interaction with the primase allows the primase to initiate lagging strand synthesis and fully activates the helicase. Loaded by the helicase assembly factor on replication forks that begin at discrete replication origin sequences, as well as on forks that are created during recombination.
Subunit	Homohexamer. The homohexamer is a trimer of asymmetric dimers. Interacts with the DNA primase; this interaction forms the active primosome complex, which is composed of 6 helicase and 1 primase subunits and expresses full helicase and primase activities. Interacts (via C-terminus) with the helicase assembly factor; this interaction brings about the rapid assembly of the helicase onto ssDNA. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the DnaB-like replicative helicase and the helicase assembly factor.
Similarity	Belongs to the helicase family. DnaB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003678; Molecular function: DNA helicase activity.

Cross-references [?]

Features [?]

From: HELIC_BPT4 (P04530)

Key From To Description Tag Condition FTGroup

BINDING 197 204 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [AG]-[AGP]-[IPSTV]-[GHN]-[AFSV]-G-K-[ST]

Additional information [?]