HAMAP rule MF_04155

General rule information [?]

Accession	MF_04155
Dates	8-FEB-2021 (Created) 19-NOV-2022 (Last updated, Version 6)
Name	Helic_T4
Scope(s)	Viruses
Template(s)	P04530 (HELIC_BPT4); [ Recover all ]
Triggered by	HAMAP; MF_04155 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HELIC
case <OC:Tequatrovirus>
RecName: Full=DnaB-like replicative helicase;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=Gene product 41;<br />                  Short=Gp41;
Gene name	Name=41;
else
RecName: Full=DnaB-like replicative helicase;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;
end case

Comments [?]

FUNCTION	ATP-dependent DNA helicase essential for viral DNA replication and recombination. The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis. Interaction with the primase allows the primase to initiate lagging strand synthesis and fully activates the helicase. Loaded by the helicase assembly factor on replication forks that begin at discrete replication origin sequences, as well as on forks that are created during recombination.
SUBUNIT	Homohexamer. The homohexamer is a trimer of asymmetric dimers. Interacts with the DNA primase; this interaction forms the active primosome complex, which is composed of 6 helicase and 1 primase subunits and expresses full helicase and primase activities. Interacts (via C-terminus) with the helicase assembly factor; this interaction brings about the rapid assembly of the helicase onto ssDNA. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the DnaB-like replicative helicase and the helicase assembly factor.
SIMILARITY	Belongs to the helicase family. DnaB subfamily.

Keywords [?]

ATP-binding
DNA replication
DNA-binding
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Viral DNA replication

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0003678; Molecular function:DNA helicase activity

Cross-references [?]

Features [?]

From: HELIC_BPT4 (P04530)

Key

From

Description

Tag

Condition

FTGroup

BINDING

197

204

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

[AG]-[AGP]-[IPSTV]-[GHN]-[AFSV]-G-K-[ST]

Additional information [?]