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HAMAP rule MF_04155

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General rule information [?]

Accession MF_04155
Dates 8-FEB-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Name Helic_T4
Scope(s) Viruses
Template(s) P04530 (HELIC_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04155 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HELIC
case <OC:Tequatrovirus>
RecName: Full=DnaB-like replicative helicase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=Gene product 41;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=Gp41;
Gene name Name=41;
RecName: Full=DnaB-like replicative helicase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;
end case

Comments [?]

FUNCTIONATP-dependent DNA helicase essential for viral DNA replication and recombination. The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis. Interaction with the primase allows the primase to initiate lagging strand synthesis and fully activates the helicase. Loaded by the helicase assembly factor on replication forks that begin at discrete replication origin sequences, as well as on forks that are created during recombination.
SUBUNITHomohexamer. The homohexamer is a trimer of asymmetric dimers. Interacts with the DNA primase; this interaction forms the active primosome complex, which is composed of 6 helicase and 1 primase subunits and expresses full helicase and primase activities. Interacts (via C-terminus) with the helicase assembly factor; this interaction brings about the rapid assembly of the helicase onto ssDNA. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the DnaB-like replicative helicase and the helicase assembly factor.
SIMILARITYBelongs to the helicase family. DnaB subfamily.

Keywords [?]

DNA replication
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Viral DNA replication

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003678; Molecular function:DNA helicase activity

Cross-references [?]

Pfam PF00772; DnaB; 0-1;
Pfam PF03796; DnaB_C; 0-1;
Pfam PF07068; Gp23; 0-1;

Features [?]

From: HELIC_BPT4 (P04530)
Key From To Description Tag Condition FTGroup
BINDING 197 204 /ligand="ATP"

Additional information [?]

Size range 380-680 amino acids
Related rules None
Fusion Nter: None Cter: None

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