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HAMAP rule MF_04155

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General rule information [?]

Accession MF_04155
Dates 8-FEB-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Name Helic_T4
Template P04530 (HELIC_BPT4)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Tequatrovirus>
Protein name
RecName: Full=DnaB-like replicative helicase;
EC 3.6.4.-;
AltName: Full=Gene product 41;
Gene name
Protein name
RecName: Full=DnaB-like replicative helicase;
EC 3.6.4.-;
end case

Comments [?]

Function ATP-dependent DNA helicase essential for viral DNA replication and recombination. The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis. Interaction with the primase allows the primase to initiate lagging strand synthesis and fully activates the helicase. Loaded by the helicase assembly factor on replication forks that begin at discrete replication origin sequences, as well as on forks that are created during recombination.
Subunit Homohexamer. The homohexamer is a trimer of asymmetric dimers. Interacts with the DNA primase; this interaction forms the active primosome complex, which is composed of 6 helicase and 1 primase subunits and expresses full helicase and primase activities. Interacts (via C-terminus) with the helicase assembly factor; this interaction brings about the rapid assembly of the helicase onto ssDNA. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the DnaB-like replicative helicase and the helicase assembly factor.
Similarity Belongs to the helicase family. DnaB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003678; Molecular function: DNA helicase activity.

Cross-references [?]

PROSITE PS51199; SF4_HELICASE; 0-1; trigger=PRU00596;
Pfam PF00772; DnaB; 0-1;
PF03796; DnaB_C; 0-1;
PF07068; Gp23; 0-1;

Features [?]

From: HELIC_BPT4 (P04530)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     197     204       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [AG]-[AGP]-[IPSTV]-[GHN]-[AFSV]-G-K-[ST]  

Additional information [?]

Size range 380-680 amino acids
Related rules None
Fusion None