HAMAP rule MF_04156

General rule information [?]

Accession	MF_04156
Dates	26-FEB-2021 (Created) 31-MAR-2021 (Last updated, Version 3)
Name	HELIC_LOADER_T4
Scope(s)	Viruses Enterobacteria phage T4
Template(s)	P13342 (HLOAD_BPT4); [ Recover all ]
Triggered by	HAMAP; MF_04156 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HLOAD
case <OC:Tequatrovirus>
RecName: Full=DNA helicase assembly protein;<br /> AltName: Full=Gene product 59;<br />                  Short=Gp59;<br /> AltName: Full=Helicase loader;<br /> AltName: Full=Helicase loading protein;
Gene name	Name=59;
else
RecName: Full=DNA helicase assembly protein;<br /> AltName: Full=Helicase loader;<br /> AltName: Full=Helicase loading protein;
end case

Comments [?]

FUNCTION	DNA helicase loader protein that participates in viral DNA replication, recombination, and repair. At the fork, required for loading of the replicative helicase onto DNA protected by the ssDNA- binding protein. Coordinates simultaneous synthesis of leading- and lagging-strands.
SUBUNIT	Monomer. Homohexamer; when associated with DNA. Interacts (via C-terminus) with the DnaB-like replicative helicase (via C-terminus); this interaction brings about the rapid assembly of the helicase onto ssDNA. Interacts (via C-terminus) with the single-stranded DNA-binding protein; a ternary complex between the helicase assembly protein, the single-stranded DNA-binding protein and ssDNA is an obligatory intermediate in the helicase loading mechanism. Interacts with the viral DNA polymerase. Binds to single and double-stranded DNA. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein (SSB), the primase, the DnaB-like replicative helicase and the helicase assembly factor.
SIMILARITY	Belongs to the Tequatrovirus DNA helicase assembly protein family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding

GO:0039693; Biological process:viral DNA genome replication

Cross-references [?]

Features [?]

Additional information [?]