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HAMAP rule MF_04156

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General rule information [?]

Accession MF_04156
Dates 26-FEB-2021 (Created)
31-MAR-2021 (Last updated, Version 3)
Scope(s) Viruses
Enterobacteria phage T4
Template(s) P13342 (HLOAD_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04156 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HLOAD
case <OC:Tequatrovirus>
RecName: Full=DNA helicase assembly protein;<br /> AltName: Full=Gene product 59;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=Gp59;<br /> AltName: Full=Helicase loader;<br /> AltName: Full=Helicase loading protein;
Gene name Name=59;
RecName: Full=DNA helicase assembly protein;<br /> AltName: Full=Helicase loader;<br /> AltName: Full=Helicase loading protein;
end case

Comments [?]

FUNCTIONDNA helicase loader protein that participates in viral DNA replication, recombination, and repair. At the fork, required for loading of the replicative helicase onto DNA protected by the ssDNA- binding protein. Coordinates simultaneous synthesis of leading- and lagging-strands.
SUBUNITMonomer. Homohexamer; when associated with DNA. Interacts (via C-terminus) with the DnaB-like replicative helicase (via C-terminus); this interaction brings about the rapid assembly of the helicase onto ssDNA. Interacts (via C-terminus) with the single-stranded DNA-binding protein; a ternary complex between the helicase assembly protein, the single-stranded DNA-binding protein and ssDNA is an obligatory intermediate in the helicase loading mechanism. Interacts with the viral DNA polymerase. Binds to single and double-stranded DNA. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein (SSB), the primase, the DnaB-like replicative helicase and the helicase assembly factor.
SIMILARITYBelongs to the Tequatrovirus DNA helicase assembly protein family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0039693; Biological process:viral DNA genome replication

Cross-references [?]

Pfam PF08993; T4_Gp59_N; 1;
Pfam PF08994; T4_Gp59_C; 1;
PIRSF PIRSF004374; Phage-associated_Gp59; 1;

Features [?]

Additional information [?]

Size range 150-300 amino acids
Related rules None
Fusion Nter: None Cter: None

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