HAMAP rule MF_04158
General rule information
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| Accession | MF_04158 |
| Dates | 26-FEB-2021 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | Antitermination_lambda |
| Scope(s) |
Viruses |
| Template(s) | P03047 (REGQ_LAMBD); [ Recover all ] |
| Triggered by |
HAMAP; MF_04158 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | REGQ |
| Protein name | RecName: Full=Antitermination protein Q; |
| case <OC:Lambdavirus> | |
| Gene name | Name=Q; |
| end case | |
Comments
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| FUNCTION | Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes. Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP. To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation. Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes. |
| SUBUNIT | Interacts with host RPOB (via flap domain); this interaction renders host RNAP resistant to transcription pausing and allows it to read through termination signals. Interacts with host RNA polymerase sigma factor RPOD (via domain-4). Interacts with host NUSA (via N- terminus and AR2 domain); this interaction releases the autoinhibition of NUSA. |
| SIMILARITY | Belongs to the phage antitermination Q type 2 family. |
Keywords
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| DNA-binding | |
| Host-virus interaction | |
| Transcription regulation | |
| Transcription termination | |
| case <FTGroup:1> | |
| Zinc | |
| Zinc-finger | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| GO:0006353; Biological process:DNA-templated transcription termination | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
| GO:0031564; Biological process:transcription antitermination | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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| Pfam | PF03589; Antiterm; 0-2; |
Features
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| From: REGQ_LAMBD (P03047) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <FTGroup:1> | ||||||||||||
| ZN_FING | 118 | 147 | ||||||||||
| end case | ||||||||||||
| DNA_BIND | 171 | 192 | ||||||||||
| BINDING | 118 | 118 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 121 | 121 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 144 | 144 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 147 | 147 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| SITE | 101 | 101 | /note="Interaction with host rpoB" | T | ||||||||
| SITE | 134 | 134 | /note="Interaction with host RNA polymerase sigma factor RPOD" | E | ||||||||
| SITE | 160 | 160 | /note="Interaction with host rpoB" | A | ||||||||
| SITE | 165 | 165 | /note="Interaction with host rpoB" | T | ||||||||
Additional information
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| Size range | 190-280 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |