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HAMAP rule MF_04158

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General rule information [?]

Accession MF_04158
Dates 26-FEB-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Name Antitermination_lambda
Scope
Viruses
Template P03047 (REGQ_LAMBD)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
REGQ
Protein name
RecName: Full=Antitermination protein Q;
case <OC:Lambdavirus>
Gene name
Q
end case

Comments [?]

Function Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes. Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP. To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation. Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes.
Subunit Interacts with host RPOB (via flap domain); this interaction renders host RNAP resistant to transcription pausing and allows it to read through termination signals. Interacts with host RNA polymerase sigma factor RPOD (via domain-4). Interacts with host NUSA (via N-terminus and AR2 domain); this interaction releases the autoinhibition of NUSA.
Similarity Belongs to the phage antitermination Q type 2 family.

Keywords [?]

DNA-binding
Host-virus interaction
Transcription regulation
Transcription termination
case <FTGroup:1>
Zinc
Zinc-finger
Metal-binding
end case

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0006353; Biological process: DNA-templated transcription termination.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0031564; Biological process: transcription antitermination.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF03589; Antiterm; 0-2;

Features [?]

case <FTGroup:1>
From: REGQ_LAMBD (P03047)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     118     147                
end case
DNA_BIND     171     192                
BINDING     118     118       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     121     121       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     144     144       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     147     147       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
SITE (Optional)     101     101       Interaction with host rpoB     T  
SITE (Optional)     134     134       Interaction with host RNA polymerase sigma factor RPOD     E  
SITE (Optional)     160     160       Interaction with host rpoB     A  
SITE (Optional)     165     165       Interaction with host rpoB     T  

Additional information [?]

Size range 190-280 amino acids
Related rules None
Fusion None


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