HAMAP rule MF_04162

General rule information [?]

Accession	MF_04162
Dates	20-APR-2021 (Created) 19-NOV-2022 (Last updated, Version 6)
Name	T4_Clamp_Loader_L
Scope(s)	Viruses
Template(s)	P04526 (LOADL_BPT4); [ Recover all ]
Triggered by	HAMAP; MF_04162 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LOADL
Protein name	RecName: Full=Sliding-clamp-loader large subunit; EC=3.6.4.-; AltName: Full=Clamp loader gp44 subunit;

Comments [?]

FUNCTION	Forms the sliding-clamp-loader together with the small subunit. Functions as an ATPase enzyme. The clamp loader holds the clamp in an open conformation and places it onto the DNA. 4 ATP molecules must bind to the sliding-clamp-loader before the latter can open the sliding clamp. ATP hydrolysis triggers the detachment of the sliding clamp from the sliding-clamp-loader, freeing the sliding clamp to track along DNA.
SUBUNIT	The sliding-clamp-loader consists of 4 large subunits and 1 small subunit. Interacts with the sliding clamp; this interaction allows the sliding-clamp-loader to open the sliding clamp. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the helicase and the helicase assembly factor.
SIMILARITY	Belongs to the Tevenvirinae sliding-clamp-loader large subunit family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0003677; Molecular function:DNA binding

GO:0039693; Biological process:viral DNA genome replication

GO:0003689; Molecular function:DNA clamp loader activity

GO:0016887; Molecular function:ATP hydrolysis activity