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HAMAP rule MF_04162

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General rule information [?]

Accession MF_04162
Dates 20-APR-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Name T4_Clamp_Loader_L
Scope(s) Viruses
Template(s) P04526 (LOADL_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04162 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LOADL
Protein name RecName: Full=Sliding-clamp-loader large subunit;
AltName: Full=Clamp loader gp44 subunit;

Comments [?]

FUNCTIONForms the sliding-clamp-loader together with the small subunit. Functions as an ATPase enzyme. The clamp loader holds the clamp in an open conformation and places it onto the DNA. 4 ATP molecules must bind to the sliding-clamp-loader before the latter can open the sliding clamp. ATP hydrolysis triggers the detachment of the sliding clamp from the sliding-clamp-loader, freeing the sliding clamp to track along DNA.
SUBUNITThe sliding-clamp-loader consists of 4 large subunits and 1 small subunit. Interacts with the sliding clamp; this interaction allows the sliding-clamp-loader to open the sliding clamp. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the helicase and the helicase assembly factor.
SIMILARITYBelongs to the Tevenvirinae sliding-clamp-loader large subunit family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0039693; Biological process:viral DNA genome replication
GO:0003689; Molecular function:DNA clamp loader activity
GO:0016887; Molecular function:ATP hydrolysis activity

Cross-references [?]

Pfam PF00004; AAA; 0-1;
Pfam PF06144; DNA_pol3_delta; 0-1;
Pfam PF08542; Rep_fac_C; 0-1;

Features [?]

From: LOADL_BPT4 (P04526)
Key From To Description Tag Condition FTGroup
BINDING 12 15 /ligand="ATP"
BINDING 53 58 /ligand="ATP"
BINDING 24 24 /ligand="ATP"
BINDING 205 205 /ligand="ATP"

Additional information [?]

Size range 260-490 amino acids
Related rules None
Fusion Nter: None Cter: None

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