HAMAP rule MF_04162
General rule information
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Accession | MF_04162 |
Dates | 20-APR-2021 (Created) 19-NOV-2022 (Last updated, Version 6) |
Name | T4_Clamp_Loader_L |
Scope | Viruses |
Template | P04526 (LOADL_BPT4) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Comments
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Function | Forms the sliding-clamp-loader together with the small subunit. Functions as an ATPase enzyme. The clamp loader holds the clamp in an open conformation and places it onto the DNA. 4 ATP molecules must bind to the sliding-clamp-loader before the latter can open the sliding clamp. ATP hydrolysis triggers the detachment of the sliding clamp from the sliding-clamp-loader, freeing the sliding clamp to track along DNA. |
Subunit | The sliding-clamp-loader consists of 4 large subunits and 1 small subunit. Interacts with the sliding clamp; this interaction allows the sliding-clamp-loader to open the sliding clamp. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the helicase and the helicase assembly factor. |
Similarity | Belongs to the Tevenvirinae sliding-clamp-loader large subunit family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0039693; Biological process: viral DNA genome replication.
GO:0003689; Molecular function: DNA clamp loader activity.
GO:0016887; Molecular function: ATP hydrolysis activity.
GO:0003677; Molecular function: DNA binding.
GO:0039693; Biological process: viral DNA genome replication.
GO:0003689; Molecular function: DNA clamp loader activity.
GO:0016887; Molecular function: ATP hydrolysis activity.
Cross-references
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Features
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From: LOADL_BPT4 (P04526) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 12 | 15 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [DEILSTV]-[EILMNQ]-[KR]-Y | ||||||||
BINDING (Optional) | 53 | 58 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x-G-K-[ST]-[ST] | ||||||||
BINDING (Optional) | 24 | 24 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [ILV] | ||||||||
BINDING (Optional) | 205 | 205 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R |
Additional information
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Size range | 260-490 amino acids |
Related rules | None |
Fusion | None |