HAMAP rule MF_04162

General rule information [?]

Accession	MF_04162
Dates	20-APR-2021 (Created) 19-NOV-2022 (Last updated, Version 6)

Name	T4_Clamp_Loader_L

Scope

Viruses

Template

P04526 (LOADL_BPT4)

Triggered by

HAMAP; MF_04162 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

LOADL

Protein name

RecName:		Full=Sliding-clamp-loader large subunit;
		EC 3.6.4.-;
AltName:		Full=Clamp loader gp44 subunit;

Comments [?]

Function	Forms the sliding-clamp-loader together with the small subunit. Functions as an ATPase enzyme. The clamp loader holds the clamp in an open conformation and places it onto the DNA. 4 ATP molecules must bind to the sliding-clamp-loader before the latter can open the sliding clamp. ATP hydrolysis triggers the detachment of the sliding clamp from the sliding-clamp-loader, freeing the sliding clamp to track along DNA.
Subunit	The sliding-clamp-loader consists of 4 large subunits and 1 small subunit. Interacts with the sliding clamp; this interaction allows the sliding-clamp-loader to open the sliding clamp. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the helicase and the helicase assembly factor.
Similarity	Belongs to the Tevenvirinae sliding-clamp-loader large subunit family.

Keywords [?]

ATP-binding
Viral DNA replication
DNA-binding
Hydrolase
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0039693; Biological process: viral DNA genome replication.
GO:0003689; Molecular function: DNA clamp loader activity.
GO:0016887; Molecular function: ATP hydrolysis activity.

Cross-references [?]

Pfam	PF00004; AAA; 0-1;
	PF06144; DNA_pol3_delta; 0-1;
	PF08542; Rep_fac_C; 0-1;

Features [?]

From: LOADL_BPT4 (P04526)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 12 15 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [DEILSTV]-[EILMNQ]-[KR]-Y

BINDING (Optional) 53 58 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-x-G-K-[ST]-[ST]

BINDING (Optional) 24 24 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [ILV]

BINDING (Optional) 205 205 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R

Additional information [?]

Size range	260-490 amino acids
Related rules	None
Fusion	None

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