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Annotation rule MF_04162
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General rule information [?]

Accession MF_04162
Dates 20-APR-2021 (Created)
17-JUN-2021 (Last updated, Version 3)
Name T4_Clamp_Loader_L
Scope
Viruses
Template P04526 (LOADL_BPT4)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LOADL
Protein name
RecName: Full=Sliding-clamp-loader large subunit;
EC 3.6.4.-;
AltName: Full=Clamp loader gp44 subunit;

Comments [?]

Function Forms the sliding-clamp-loader together with the small subunit. Functions as an ATPase enzyme. The clamp loader holds the clamp in an open conformation and places it onto the DNA. 4 ATP molecules must bind to the sliding-clamp-loader before the latter can open the sliding clamp. ATP hydrolysis triggers the detachment of the sliding clamp from the sliding-clamp-loader, freeing the sliding clamp to track along DNA.
Subunit The sliding-clamp-loader consists of 4 large subunits and 1 small subunit. Interacts with the sliding clamp; this interaction allows the sliding-clamp-loader to open the sliding clamp. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the helicase and the helicase assembly factor.
Similarity Belongs to the Tevenvirinae sliding-clamp-loader large subunit family.

Keywords [?]

ATP-binding
Viral DNA replication
DNA-binding
Hydrolase
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0039693; Biological process: viral DNA genome replication.
GO:0003689; Molecular function: DNA clamp loader activity.
GO:0140603; Molecular function: ATP hydrolysis activity.

Cross-references [?]

Pfam PF00004; AAA; 0-1;
PF06144; DNA_pol3_delta; 0-1;
PF08542; Rep_fac_C; 0-1;

Features [?]

From: LOADL_BPT4 (P04526)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     12     15       ATP     [DEILSTV]-[EILMNQ]-[KR]-Y  
NP_BIND (Optional)     53     58       ATP     G-x-G-K-[ST]-[ST]  
BINDING (Optional)     24     24       ATP; via amide nitrogen and carbonyl oxygen     [ILV]  
BINDING (Optional)     205     205       ATP     R  

Additional information [?]

Size range 260-490 amino acids
Related rules None
Fusion None


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