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HAMAP rule MF_04164

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General rule information [?]

Accession MF_04164
Dates 16-APR-2021 (Created)
20-APR-2021 (Last updated, Version 2)
Name T4_Sigma-like factor
Scope(s) Viruses
Template(s) P04524 (SIGML_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04164 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SIGML
Protein name RecName: Full=RNA polymerase sigma-like factor;
AltName: Full=Promoter specificity factor;

Comments [?]

FUNCTIONPlays a role in the transcription of the viral late genes by acting as a late promoter recognition subunit. Associates with host RNA polymerase (RNAP) core and thus replaces the host sigma-70/rpoD subunit in the complex. May also play a role in DNA packaging by interacting with the terminase subunit gp17.
SUBUNITInteracts with the host RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ to form the RNAP-gp55 holoenzyme. Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the late transcription coactivator, and the sliding clamp. Interacts with the terminase large subunit; this interaction may load the terminase onto DNA for packaging.
SIMILARITYBelongs to the Tevenvirinae RNA polymerase sigma-like factor family.

Keywords [?]

Gene Ontology [?]

GO:0016987; Molecular function:sigma factor activity
GO:0003677; Molecular function:DNA binding
GO:0019086; Biological process:late viral transcription

Cross-references [?]

Pfam PF04542; Sigma70_r2; 0-1;

Features [?]

From: SIGML_BPT4 (P04524)
Key From To Description Tag Condition FTGroup
DNA_BIND 114 114 [RK]
REGION 13 113 /note="Interaction with host RNAP core and recognition of the promoter specific element"
SITE 70 70 /note="Interaction with host RNAP" [DE]
SITE 74 74 /note="Interaction with host RNAP" [DE]
SITE 77 77 /note="Interaction with host RNAP" [DE]

Additional information [?]

Size range 134-214 amino acids
Related rules None
Fusion Nter: None Cter: None

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