HAMAP rule MF_04164
General rule information
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Accession | MF_04164 |
Dates | 16-APR-2021 (Created)
20-APR-2021 (Last updated, Version 2) |
Name | T4_Sigma-like factor |
Scope(s) |
Viruses |
Template(s) | P04524 (SIGML_BPT4); [ Recover all ] |
Triggered by |
HAMAP; MF_04164 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | SIGML |
Protein name | RecName: Full=RNA polymerase sigma-like factor; AltName: Full=Promoter specificity factor; |
Comments
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FUNCTION | Plays a role in the transcription of the viral late genes by acting as a late promoter recognition subunit. Associates with host RNA polymerase (RNAP) core and thus replaces the host sigma-70/rpoD subunit in the complex. May also play a role in DNA packaging by interacting with the terminase subunit gp17. |
SUBUNIT | Interacts with the host RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ to form the RNAP-gp55 holoenzyme. Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the late transcription coactivator, and the sliding clamp. Interacts with the terminase large subunit; this interaction may load the terminase onto DNA for packaging. |
SIMILARITY | Belongs to the Tevenvirinae RNA polymerase sigma-like factor family. |
Keywords
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DNA-binding |
Host-virus interaction |
Nucleotidyltransferase |
Sigma factor |
Viral transcription |
Transcription regulation |
Transferase |
Gene Ontology
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GO:0016987; Molecular function:sigma factor activity |
GO:0003677; Molecular function:DNA binding |
GO:0019086; Biological process:late viral transcription |
Cross-references
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Pfam | PF04542; Sigma70_r2; 0-1; |
Features
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From: SIGML_BPT4 (P04524) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DNA_BIND | 114 | 114 | [RK] | |||||||||
REGION | 13 | 113 | /note="Interaction with host RNAP core and recognition of the promoter specific element" | |||||||||
SITE | 70 | 70 | /note="Interaction with host RNAP" | [DE] | ||||||||
SITE | 74 | 74 | /note="Interaction with host RNAP" | [DE] | ||||||||
SITE | 77 | 77 | /note="Interaction with host RNAP" | [DE] |
Additional information
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Size range | 134-214 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |