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Annotation rule MF_04164
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General rule information [?]

Accession MF_04164
Dates 16-APR-2021 (Created)
20-APR-2021 (Last updated, Version 2)
Name T4_Sigma-like factor
Scope
Viruses
Template P04524 (SIGML_BPT4)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SIGML
Protein name
RecName: Full=RNA polymerase sigma-like factor;
AltName: Full=Promoter specificity factor;

Comments [?]

Function Plays a role in the transcription of the viral late genes by acting as a late promoter recognition subunit. Associates with host RNA polymerase (RNAP) core and thus replaces the host sigma-70/rpoD subunit in the complex. May also play a role in DNA packaging by interacting with the terminase subunit gp17.
Subunit Interacts with the host RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ to form the RNAP-gp55 holoenzyme. Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the late transcription coactivator, and the sliding clamp. Interacts with the terminase large subunit; this interaction may load the terminase onto DNA for packaging.
Similarity Belongs to the Tevenvirinae RNA polymerase sigma-like factor family.

Keywords [?]


Gene Ontology [?]

GO:0016987; Molecular function: sigma factor activity.
GO:0003677; Molecular function: DNA binding.
GO:0019086; Biological process: late viral transcription.

Cross-references [?]

Pfam PF04542; Sigma70_r2; 0-1;

Features [?]

From: SIGML_BPT4 (P04524)
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     114     114             [RK]  
REGION     13     113       Interaction with host RNAP core and recognition of the promoter specific element        
SITE (Optional)     70     70       Interaction with host RNAP     [DE]  
SITE (Optional)     74     74       Interaction with host RNAP     [DE]  
SITE (Optional)     77     77       Interaction with host RNAP     [DE]  

Additional information [?]

Size range 134-214 amino acids
Related rules None
Fusion None