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HAMAP rule MF_04165

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General rule information [?]

Accession MF_04165
Dates 16-APR-2021 (Created)
27-APR-2021 (Last updated, Version 3)
Scope(s) Viruses
Template(s) P13338 (LTACT_BPT4); [ Recover all ]
Triggered by HAMAP; MF_04165 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LTACT
Protein name RecName: Full=Late transcription coactivator;
AltName: Full=RNA polymerase-associated protein Gp33;

Comments [?]

FUNCTIONActivates transcription at late promoters when the sliding clamp is present. Binds to both the host RNA polymerase (RNAP) and the upstream dsDNA.
SUBUNITInteracts with the beta subunit of host RNAP RpoB (via flap domain). Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the coactivator gp33, and the sliding clamp.
DOMAINThe C-terminus is involved in transcriptional enhancement.
SIMILARITYBelongs to the Tevenvirinae late transcription coactivator family.

Keywords [?]

Gene Ontology [?]

GO:0140537; Molecular function:transcription regulator activator activity
GO:0019086; Biological process:late viral transcription

Cross-references [?]

Pfam PF16805; Trans_coact; 1;

Features [?]

From: LTACT_BPT4 (P13338)
Key From To Description Tag Condition FTGroup
REGION 62 92 /note="Interaction with host RNAP"
REGION 106 112 /note="Involved in transcriptional enhancement" [NQS]-[NST]-L-[DE]-[DFGI]-[FL]-x

Additional information [?]

Size range 60-300 amino acids
Related rules None
Fusion Nter: None Cter: None

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