HAMAP rule MF_04165
General rule information
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Accession | MF_04165 |
Dates | 16-APR-2021 (Created)
27-APR-2021 (Last updated, Version 3) |
Name | T4_TRANSCR_COACT |
Scope(s) |
Viruses |
Template(s) | P13338 (LTACT_BPT4); [ Recover all ] |
Triggered by |
HAMAP; MF_04165 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | LTACT |
Protein name | RecName: Full=Late transcription coactivator; AltName: Full=RNA polymerase-associated protein Gp33; |
Comments
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FUNCTION | Activates transcription at late promoters when the sliding clamp is present. Binds to both the host RNA polymerase (RNAP) and the upstream dsDNA. |
SUBUNIT | Interacts with the beta subunit of host RNAP RpoB (via flap domain). Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the coactivator gp33, and the sliding clamp. |
DOMAIN | The C-terminus is involved in transcriptional enhancement. |
SIMILARITY | Belongs to the Tevenvirinae late transcription coactivator family. |
Keywords
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Gene Ontology
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GO:0140537; Molecular function:transcription regulator activator activity |
GO:0019086; Biological process:late viral transcription |
Cross-references
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Pfam | PF16805; Trans_coact; 1; |
Features
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From: LTACT_BPT4 (P13338) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 62 | 92 | /note="Interaction with host RNAP" | |||||||||
REGION | 106 | 112 | /note="Involved in transcriptional enhancement" | [NQS]-[NST]-L-[DE]-[DFGI]-[FL]-x |
Additional information
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Size range | 60-300 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |