HAMAP rule MF_04165

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_04165
Accession	MF_04165
Dates	16-APR-2021 (Created) 27-APR-2021 (Last updated, Version 4)
Name	T4_TRANSCR_COACT
Scope(s)	Viruses
Template(s)	P13338; [ Recover all ]
Triggered by	HAMAP; MF_04165 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LTACT
Protein name	RecName: Full=Late transcription coactivator; AltName: Full=RNA polymerase-associated protein Gp33;

Comments [?]

FUNCTION	Activates transcription at late promoters when the sliding clamp is present. Binds to both the host RNA polymerase (RNAP) and the upstream dsDNA.
SUBUNIT	Interacts with the beta subunit of host RNAP RpoB (via flap domain). Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the coactivator gp33, and the sliding clamp.
DOMAIN	The C-terminus is involved in transcriptional enhancement.
SIMILARITY	Belongs to the Tevenvirinae late transcription coactivator family.

Keywords [?]

Gene Ontology [?]

GO:0140537; Molecular function:transcription regulator activator activity

GO:0019086; Biological process:late viral transcription

Cross-references [?]

Pfam	PF16805; Trans_coact; 1;

Features [?]

From: LTACT_BPT4 (P13338)

Key

From

Description

Tag

Condition

FTGroup

REGION

/note="Interaction with host RNAP"

REGION

106

112

/note="Involved in transcriptional enhancement"

[NQS]-[NST]-L-[DE]-[DFGI]-[FL]-x

Additional information [?]