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HAMAP rule MF_04167

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General rule information [?]

Accession MF_04167
Dates 13-JUL-2021 (Created)
3-AUG-2021 (Last updated, Version 2)
Scope(s) Viruses
Template(s) Q6QGS2 (APNUC_BPT5); [ Recover all ]
Triggered by HAMAP; MF_04167 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier APNUC
Protein name RecName: Full=DNA-(apurinic or apyrimidinic site) endonuclease;
AltName: Full=AP endonuclease;
AltName: Full=Apurinic-apyrimidinic endonuclease;

Comments [?]

FUNCTIONPerforms endonucleolytic cleavage at abasic sites, which are generated by the base-excision activity of host Ung. The cleavage generates a 5'-deoxyribose phosphate and 3'-hydroxyl end. The sites are specifically recognized through the formation of a complex with host Ung. The viral endonucleolytic activity damages the host DNA, blocks host DNA replication and induces cell division arrest. This may provide an advantage for the phage and save nucleotides for the viral replication since specifically targets the host DNA, which possesses more misincorporated uracils than the viral genome.
SUBUNITInteracts with host Ung; this interaction allows the viral AP endonuclease to localize to newly formed AP sites and cleave them, leading to inhibition of bacterial growth.
SIMILARITYBelongs to the apurinic/apyrimidinic endonuclease family.

Keywords [?]

Gene Ontology [?]

GO:0003906; Molecular function:DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0099015; Biological process:degradation of host chromosome by virus

Cross-references [?]

Features [?]

Additional information [?]

Size range 110-130 amino acids
Related rules None
Fusion Nter: None Cter: None

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