HAMAP rule MF_04167
General rule information
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Accession | MF_04167 |
Dates | 13-JUL-2021 (Created) 3-AUG-2021 (Last updated, Version 2) |
Name | APNUC_T5 |
Scope | Viruses |
Template | Q6QGS2 (APNUC_BPT5) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Comments
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Function | Performs endonucleolytic cleavage at abasic sites, which are generated by the base-excision activity of host Ung. The cleavage generates a 5'-deoxyribose phosphate and 3'-hydroxyl end. The sites are specifically recognized through the formation of a complex with host Ung. The viral endonucleolytic activity damages the host DNA, blocks host DNA replication and induces cell division arrest. This may provide an advantage for the phage and save nucleotides for the viral replication since specifically targets the host DNA, which possesses more misincorporated uracils than the viral genome. |
Subunit | Interacts with host Ung; this interaction allows the viral AP endonuclease to localize to newly formed AP sites and cleave them, leading to inhibition of bacterial growth. |
Similarity | Belongs to the apurinic/apyrimidinic endonuclease family. |
Keywords
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Bacterial host gene expression shutoff by virus
Degradation of host chromosome by virus
Endonuclease
Nuclease
Degradation of host chromosome by virus
Endonuclease
Nuclease
Gene Ontology
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GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0099015; Biological process: degradation of host chromosome by virus.
GO:0099015; Biological process: degradation of host chromosome by virus.
Additional information
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Size range | 110-130 amino acids |
Related rules | None |
Fusion | None |