HAMAP rule MF_04167

General rule information [?]

Accession	MF_04167
Dates	13-JUL-2021 (Created) 3-AUG-2021 (Last updated, Version 2)

Name

APNUC_T5

Scope

Viruses

Template

Q6QGS2 (APNUC_BPT5)

Triggered by

HAMAP; MF_04167 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

APNUC

Protein name

RecName:		Full=DNA-(apurinic or apyrimidinic site) endonuclease;
		EC 3.1.-.-;
AltName:		Full=AP endonuclease;
AltName:		Full=Apurinic-apyrimidinic endonuclease;

Comments [?]

Function	Performs endonucleolytic cleavage at abasic sites, which are generated by the base-excision activity of host Ung. The cleavage generates a 5'-deoxyribose phosphate and 3'-hydroxyl end. The sites are specifically recognized through the formation of a complex with host Ung. The viral endonucleolytic activity damages the host DNA, blocks host DNA replication and induces cell division arrest. This may provide an advantage for the phage and save nucleotides for the viral replication since specifically targets the host DNA, which possesses more misincorporated uracils than the viral genome.
Subunit	Interacts with host Ung; this interaction allows the viral AP endonuclease to localize to newly formed AP sites and cleave them, leading to inhibition of bacterial growth.
Similarity	Belongs to the apurinic/apyrimidinic endonuclease family.

Keywords [?]

Bacterial host gene expression shutoff by virus
Degradation of host chromosome by virus
Endonuclease
Nuclease

Gene Ontology [?]

GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0099015; Biological process: degradation of host chromosome by virus.

Additional information [?]

Size range	110-130 amino acids
Related rules	None
Fusion	None

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