HAMAP rule MF_04167

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_04167
Accession	MF_04167
Dates	13-JUL-2021 (Created) 3-AUG-2021 (Last updated, Version 2)
Name	APNUC_T5
Scope(s)	Viruses
Template(s)	Q6QGS2 (APNUC_BPT5); [ Recover all ]
Triggered by	HAMAP; MF_04167 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	APNUC
Protein name	RecName: Full=DNA-(apurinic or apyrimidinic site) endonuclease; EC=3.1.-.-; AltName: Full=AP endonuclease; AltName: Full=Apurinic-apyrimidinic endonuclease;

Comments [?]

FUNCTION	Performs endonucleolytic cleavage at abasic sites, which are generated by the base-excision activity of host Ung. The cleavage generates a 5'-deoxyribose phosphate and 3'-hydroxyl end. The sites are specifically recognized through the formation of a complex with host Ung. The viral endonucleolytic activity damages the host DNA, blocks host DNA replication and induces cell division arrest. This may provide an advantage for the phage and save nucleotides for the viral replication since specifically targets the host DNA, which possesses more misincorporated uracils than the viral genome.
SUBUNIT	Interacts with host Ung; this interaction allows the viral AP endonuclease to localize to newly formed AP sites and cleave them, leading to inhibition of bacterial growth.
SIMILARITY	Belongs to the apurinic/apyrimidinic endonuclease family.

Keywords [?]

Gene Ontology [?]

GO:0003906; Molecular function:DNA-(apurinic or apyrimidinic site) endonuclease activity

GO:0099015; Biological process:degradation of host chromosome by virus

Cross-references [?]

Features [?]

Additional information [?]