HAMAP rule MF_04201
General rule information
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| Accession | MF_04201 |
| Dates | 23-MAR-2018 (Created) 29-SEP-2022 (Last updated, Version 4) |
| Name | ALPHA_CORONA_M |
| Scope | Viruses; Alphacoronavirus |
| Template | P04135 (VME1_CVPPU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. |
| Subunit | Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus. |
| Subcellular location | Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer. |
| Similarity | Belongs to the alphacoronaviruses M protein family. |
Keywords
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Glycoprotein
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Gene Ontology
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GO:0030430; Cellular component: host cell cytoplasm.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0039660; Molecular function: structural constituent of virion.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0039660; Molecular function: structural constituent of virion.
Cross-references
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| Pfam | PF01635; Corona_M; 1; |
Computed features
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| General | Transmembrane; -; 3; |
Features
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| From: VME1_CVPPU (P04135) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | 18 | 47 | Virion surface | |||||||||
| TRANSMEM | 48 | 68 | Helical | |||||||||
| TOPO_DOM | 69 | 77 | Intravirion | |||||||||
| TRANSMEM | 78 | 98 | Helical | |||||||||
| TOPO_DOM | 99 | 112 | Virion surface | |||||||||
| TRANSMEM | 113 | 133 | Helical | |||||||||
| TOPO_DOM | 134 | 262 | Intravirion | |||||||||
| REGION | 237 | 252 | Interaction with N protein | |||||||||
Additional information
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| Size range | 225-262 amino acids |
| Related rules | None |
| Fusion | None |