HAMAP rule MF_04201
General rule information
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| Accession | MF_04201 |
| Dates | 23-MAR-2018 (Created)
29-SEP-2022 (Last updated, Version 4) |
| Name | ALPHA_CORONA_M |
| Scope(s) |
Viruses Alphacoronavirus |
| Template(s) | P04135 (VME1_CVPPU); [ Recover all ] |
| Triggered by |
HAMAP; MF_04201 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | VME1 |
| Protein name | RecName: Full=Membrane protein; Short=M protein; AltName: Full=E1 glycoprotein; AltName: Full=Matrix glycoprotein; AltName: Full=Membrane glycoprotein; |
| Gene name | Name=M; |
Comments
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| FUNCTION | Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. |
| SUBUNIT | Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus. |
| SUBCELLULAR LOCATION | Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer. |
| SIMILARITY | Belongs to the alphacoronaviruses M protein family. |
Keywords
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| Glycoprotein |
| Host Golgi apparatus |
| Host membrane |
| Membrane |
| Transmembrane |
| Transmembrane helix |
| Viral envelope protein |
| Viral matrix protein |
| Virion |
Gene Ontology
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| GO:0030430; Cellular component:host cell cytoplasm |
| GO:0044178; Cellular component:host cell Golgi membrane |
| GO:0016020; Cellular component:membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0055036; Cellular component:virion membrane |
| GO:0039660; Molecular function:structural constituent of virion |
Cross-references
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| Pfam | PF01635; Corona_M; 1; |
| General | Transmembrane; -; 3; |
Features
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| From: VME1_CVPPU (P04135) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | 18 | 47 | /note="Virion surface" | |||||||||
| TRANSMEM | 48 | 68 | /note="Helical" | |||||||||
| TOPO_DOM | 69 | 77 | /note="Intravirion" | |||||||||
| TRANSMEM | 78 | 98 | /note="Helical" | |||||||||
| TOPO_DOM | 99 | 112 | /note="Virion surface" | |||||||||
| TRANSMEM | 113 | 133 | /note="Helical" | |||||||||
| TOPO_DOM | 134 | 262 | /note="Intravirion" | |||||||||
| REGION | 237 | 252 | /note="Interaction with N protein" | |||||||||
Additional information
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| Size range | 225-262 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |