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HAMAP rule MF_04201

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General rule information [?]

Accession MF_04201
Dates 23-MAR-2018 (Created)
29-SEP-2022 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P04135 (VME1_CVPPU); [ Recover all ]
Triggered by HAMAP; MF_04201 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VME1
Protein name RecName: Full=Membrane protein;
                 Short=M protein;
AltName: Full=E1 glycoprotein;
AltName: Full=Matrix glycoprotein;
AltName: Full=Membrane glycoprotein;
Gene name Name=M;

Comments [?]

FUNCTIONComponent of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
SUBUNITHomomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
SUBCELLULAR LOCATIONVirion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
SIMILARITYBelongs to the alphacoronaviruses M protein family.

Keywords [?]

Gene Ontology [?]

GO:0030430; Cellular component:host cell cytoplasm
GO:0044178; Cellular component:host cell Golgi membrane
GO:0016020; Cellular component:membrane
GO:0019031; Cellular component:viral envelope
GO:0055036; Cellular component:virion membrane
GO:0039660; Molecular function:structural constituent of virion

Cross-references [?]

Pfam PF01635; Corona_M; 1;
General Transmembrane; -; 3;

Features [?]

From: VME1_CVPPU (P04135)
Key From To Description Tag Condition FTGroup
TOPO_DOM 18 47 /note="Virion surface"
TRANSMEM 48 68 /note="Helical"
TOPO_DOM 69 77 /note="Intravirion"
TRANSMEM 78 98 /note="Helical"
TOPO_DOM 99 112 /note="Virion surface"
TRANSMEM 113 133 /note="Helical"
TOPO_DOM 134 262 /note="Intravirion"
REGION 237 252 /note="Interaction with N protein"

Additional information [?]

Size range 225-262 amino acids
Related rules None
Fusion Nter: None Cter: None

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