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HAMAP rule MF_04201

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General rule information [?]

Accession MF_04201
Dates 23-MAR-2018 (Created)
29-SEP-2022 (Last updated, Version 4)
Viruses; Alphacoronavirus
Template P04135 (VME1_CVPPU)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Membrane protein;
Short=M protein;
AltName: Full=E1 glycoprotein;
AltName: Full=Matrix glycoprotein;
AltName: Full=Membrane glycoprotein;
Gene name

Comments [?]

Function Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Subcellular location Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
Similarity Belongs to the alphacoronaviruses M protein family.

Keywords [?]

Gene Ontology [?]

GO:0030430; Cellular component: host cell cytoplasm.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0039660; Molecular function: structural constituent of virion.

Cross-references [?]

Pfam PF01635; Corona_M; 1;

Computed features [?]

General Transmembrane; -; 3;

Features [?]

From: VME1_CVPPU (P04135)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     18     47       Virion surface        
TRANSMEM     48     68       Helical        
TOPO_DOM     69     77       Intravirion        
TRANSMEM     78     98       Helical        
TOPO_DOM     99     112       Virion surface        
TRANSMEM     113     133       Helical        
TOPO_DOM     134     262       Intravirion        
REGION     237     252       Interaction with N protein        

Additional information [?]

Size range 225-262 amino acids
Related rules None
Fusion None