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HAMAP rule MF_04204

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General rule information [?]

Accession MF_04204
Dates 3-APR-2018 (Created)
30-MAY-2023 (Last updated, Version 7)
Viruses; Betacoronavirus
Template P59637 (VEMP_SARS)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Envelope small membrane protein;
Short=E protein;
Short=sM protein;
Gene name

Comments [?]

Function Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Subcellular location Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Similarity Belongs to the betacoronaviruses E protein family.

Keywords [?]

Gene Ontology [?]

GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016020; Cellular component: membrane.
GO:0140975; Biological process: disruption of cellular component of another organism.
GO:0046760; Biological process: viral budding from Golgi membrane.

Cross-references [?]

Pfam PF02723; NS3_envE; 1;

Computed features [?]

General Transmembrane; -; 1;

Features [?]

From: VEMP_SARS (P59637)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     16       Virion surface        
TRANSMEM     17     37       Helical        
TOPO_DOM     38     Cter       Intravirion        

Additional information [?]

Size range 76-88 amino acids
Related rules None
Fusion None