HAMAP rule MF_04204

General rule information [?]

Accession	MF_04204
Dates	3-APR-2018 (Created) 30-MAY-2023 (Last updated, Version 7)

Name	BETA_CORONA_E

Scope

Viruses; Betacoronavirus

Template

P59637 (VEMP_SARS)

Triggered by

HAMAP; MF_04204 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

VEMP

Protein name

RecName:		Full=Envelope small membrane protein;
		Short=E protein;
		Short=sM protein;

Gene name

Comments [?]

Function	Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit	Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Subcellular location	Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Similarity	Belongs to the betacoronaviruses E protein family.

Keywords [?]

Apoptosis
Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016020; Cellular component: membrane.
GO:0140975; Biological process: disruption of cellular component of another organism.
GO:0046760; Biological process: viral budding from Golgi membrane.

Cross-references [?]

Pfam	PF02723; NS3_envE; 1;

Computed features [?]

General

Transmembrane; -; 1;

Features [?]

From: VEMP_SARS (P59637)

Key From To Description Tag Condition FTGroup

TOPO_DOM Nter 16 Virion surface

TRANSMEM 17 37 Helical

TOPO_DOM 38 Cter Intravirion

Additional information [?]

Size range	76-88 amino acids
Related rules	None
Fusion	None

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