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HAMAP rule MF_04204

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General rule information [?]

Accession MF_04204
Dates 3-APR-2018 (Created)
28-JUL-2023 (Last updated, Version 8)
Scope(s) Viruses
Template(s) P59637 (VEMP_SARS); [ Recover all ]
Triggered by HAMAP; MF_04204 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VEMP
Protein name RecName: Full=Envelope small membrane protein;
                 Short=E protein;
                 Short=sM protein;
Gene name Name=E;

Comments [?]

FUNCTIONPlays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
SUBUNITHomopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
SUBCELLULAR LOCATIONHost Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
SIMILARITYBelongs to the betacoronaviruses E protein family.

Keywords [?]

Gene Ontology [?]

GO:0044177; Cellular component:host cell Golgi apparatus
GO:0044178; Cellular component:host cell Golgi membrane
GO:0016020; Cellular component:membrane
GO:0140975; Biological process:disruption of cellular anatomical structure in another organism
GO:0046760; Biological process:viral budding from Golgi membrane

Cross-references [?]

Pfam PF02723; NS3_envE; 1;
General Transmembrane; -; 1;

Features [?]

From: VEMP_SARS (P59637)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 16 /note="Virion surface"
TRANSMEM 17 37 /note="Helical"
TOPO_DOM 38 Cter /note="Intravirion"

Additional information [?]

Size range 76-88 amino acids
Related rules None
Fusion Nter: None Cter: None

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