HAMAP rule MF_04204
General rule information
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Accession | MF_04204 |
Dates | 3-APR-2018 (Created)
28-JUL-2023 (Last updated, Version 8) |
Name | BETA_CORONA_E |
Scope(s) |
Viruses Betacoronavirus |
Template(s) | P59637 (VEMP_SARS); [ Recover all ] |
Triggered by |
HAMAP; MF_04204 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | VEMP |
Protein name | RecName: Full=Envelope small membrane protein; Short=E protein; Short=sM protein; |
Gene name | Name=E; |
Comments
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FUNCTION | Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. |
SUBUNIT | Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein. |
SUBCELLULAR LOCATION | Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal. |
SIMILARITY | Belongs to the betacoronaviruses E protein family. |
Keywords
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Gene Ontology
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GO:0044177; Cellular component:host cell Golgi apparatus |
GO:0044178; Cellular component:host cell Golgi membrane |
GO:0016020; Cellular component:membrane |
GO:0140975; Biological process:disruption of cellular anatomical structure in another organism |
GO:0046760; Biological process:viral budding from Golgi membrane |
Cross-references
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Pfam | PF02723; NS3_envE; 1; |
General | Transmembrane; -; 1; |
Features
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From: VEMP_SARS (P59637) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TOPO_DOM | Nter | 16 | /note="Virion surface" | |||||||||
TRANSMEM | 17 | 37 | /note="Helical" | |||||||||
TOPO_DOM | 38 | Cter | /note="Intravirion" |
Additional information
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Size range | 76-88 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |