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Annotation rule MF_04205 |
Accession | MF_04205 |
Dates | 3-APR-2018 (Created) 20-NOV-2019 (Last updated, Version 3) |
Name | ALPHA_CORONA_E |
Scope | Viruses; Alphacoronavirus |
Template | Q6Q1S0 (VEMP_CVHNL) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. |
Subunit | Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein. |
Subcellular location | Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal. |
Similarity | Belongs to the alphacoronaviruses E protein family. |
Pfam | PF02723; NS3_envE; 1; |
General | Transmembrane; -; 1; |
From: VEMP_CVHNL (Q6Q1S0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TOPO_DOM | Nter | 15 | Virion surface | |||||||||
TRANSMEM | 16 | 36 | Helical | |||||||||
TOPO_DOM | 37 | Cter | Intravirion |
Size range | 76-82 amino acids |
Related rules | None |
Fusion | None |