HAMAP rule MF_04205
General rule information
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| Accession | MF_04205 |
| Dates | 3-APR-2018 (Created)
28-JUL-2023 (Last updated, Version 7) |
| Name | ALPHA_CORONA_E |
| Scope(s) |
Viruses Alphacoronavirus |
| Template(s) | Q6Q1S0 (VEMP_CVHNL); [ Recover all ] |
| Triggered by |
HAMAP; MF_04205 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | VEMP |
| Protein name | RecName: Full=Envelope small membrane protein; Short=E protein; Short=sM protein; |
| Gene name | Name=E; |
Comments
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| FUNCTION | Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. |
| SUBUNIT | Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein. |
| SUBCELLULAR LOCATION | Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal. |
| SIMILARITY | Belongs to the alphacoronaviruses E protein family. |
Keywords
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Gene Ontology
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| GO:0044177; Cellular component:host cell Golgi apparatus |
| GO:0044178; Cellular component:host cell Golgi membrane |
| GO:0016020; Cellular component:membrane |
| GO:0140975; Biological process:disruption of cellular anatomical structure in another organism |
| GO:0046760; Biological process:viral budding from Golgi membrane |
Cross-references
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| Pfam | PF02723; NS3_envE; 1; |
| General | Transmembrane; -; 1; |
Features
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| From: VEMP_CVHNL (Q6Q1S0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 15 | /note="Virion surface" | |||||||||
| TRANSMEM | 16 | 36 | /note="Helical" | |||||||||
| TOPO_DOM | 37 | Cter | /note="Intravirion" | |||||||||
Additional information
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| Size range | 76-82 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |