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| Annotation rule MF_04205 |
General rule information
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| Accession | MF_04205 |
| Dates | 3-APR-2018 (Created) 20-NOV-2019 (Last updated, Version 3) |
| Name | ALPHA_CORONA_E |
| Scope | Viruses; Alphacoronavirus |
| Template | Q6Q1S0 (VEMP_CVHNL) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. |
| Subunit | Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein. |
| Subcellular location | Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal. |
| Similarity | Belongs to the alphacoronaviruses E protein family. |
Keywords
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Gene Ontology
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GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0044662; Biological process: disruption by virus of host cell membrane.
GO:0046760; Biological process: viral budding from Golgi membrane.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0044662; Biological process: disruption by virus of host cell membrane.
GO:0046760; Biological process: viral budding from Golgi membrane.
Cross-references
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| Pfam | PF02723; NS3_envE; 1; |
Computed features
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| General | Transmembrane; -; 1; |
Features
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| From: VEMP_CVHNL (Q6Q1S0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 15 | Virion surface | |||||||||
| TRANSMEM | 16 | 36 | Helical | |||||||||
| TOPO_DOM | 37 | Cter | Intravirion | |||||||||
Additional information
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| Size range | 76-82 amino acids |
| Related rules | None |
| Fusion | None |