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Annotation rule MF_04206
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General rule information [?]

Accession MF_04206
Dates 3-APR-2018 (Created)
20-NOV-2019 (Last updated, Version 3)
Name GAMMA_CORONA_E
Scope
Viruses; Gammacoronavirus
Template Q89894 (VEMP_IBVB)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
VEMP
Protein name
RecName: Full=Envelope small membrane protein;
Short=E protein;
Short=sM protein;
Gene name
E

Comments [?]

Function Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.
Subcellular location Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Similarity Belongs to the gammacoronaviruses E protein family.

Keywords [?]


Gene Ontology [?]

GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0044662; Biological process: disruption by virus of host cell membrane.
GO:0046760; Biological process: viral budding from Golgi membrane.

Cross-references [?]

Pfam PF03620; IBV_3C; 1;

Computed features [?]

General Transmembrane; -; 1;

Features [?]

From: VEMP_IBVB (Q89894)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     10       Virion surface        
TRANSMEM     11     31       Helical        
TOPO_DOM     32     Cter       Intravirion        

Additional information [?]

Size range 93-109 amino acids
Related rules None
Fusion None