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HAMAP rule MF_04206

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General rule information [?]

Accession MF_04206
Dates 3-APR-2018 (Created)
28-JUL-2023 (Last updated, Version 7)
Scope(s) Viruses
Template(s) Q89894 (VEMP_IBVB); [ Recover all ]
Triggered by HAMAP; MF_04206 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VEMP
Protein name RecName: Full=Envelope small membrane protein;
                 Short=E protein;
                 Short=sM protein;
Gene name Name=E;

Comments [?]

FUNCTIONPlays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
SUBUNITHomooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.
SUBCELLULAR LOCATIONHost Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
SIMILARITYBelongs to the gammacoronaviruses E protein family.

Keywords [?]

Gene Ontology [?]

GO:0044177; Cellular component:host cell Golgi apparatus
GO:0044178; Cellular component:host cell Golgi membrane
GO:0016020; Cellular component:membrane
GO:0140975; Biological process:disruption of cellular anatomical structure in another organism
GO:0046760; Biological process:viral budding from Golgi membrane

Cross-references [?]

Pfam PF03620; IBV_3C; 1;
General Transmembrane; -; 1;

Features [?]

From: VEMP_IBVB (Q89894)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 10 /note="Virion surface"
TRANSMEM 11 31 /note="Helical"
TOPO_DOM 32 Cter /note="Intravirion"

Additional information [?]

Size range 93-109 amino acids
Related rules None
Fusion Nter: None Cter: None

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