HAMAP rule MF_04206
General rule information
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Accession | MF_04206 |
Dates | 3-APR-2018 (Created)
28-JUL-2023 (Last updated, Version 7) |
Name | GAMMA_CORONA_E |
Scope(s) |
Viruses Gammacoronavirus |
Template(s) | Q89894 (VEMP_IBVB); [ Recover all ] |
Triggered by |
HAMAP; MF_04206 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | VEMP |
Protein name | RecName: Full=Envelope small membrane protein; Short=E protein; Short=sM protein; |
Gene name | Name=E; |
Comments
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FUNCTION | Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. |
SUBUNIT | Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein. |
SUBCELLULAR LOCATION | Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal. |
SIMILARITY | Belongs to the gammacoronaviruses E protein family. |
Keywords
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Gene Ontology
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GO:0044177; Cellular component:host cell Golgi apparatus |
GO:0044178; Cellular component:host cell Golgi membrane |
GO:0016020; Cellular component:membrane |
GO:0140975; Biological process:disruption of cellular anatomical structure in another organism |
GO:0046760; Biological process:viral budding from Golgi membrane |
Cross-references
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Pfam | PF03620; IBV_3C; 1; |
General | Transmembrane; -; 1; |
Features
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From: VEMP_IBVB (Q89894) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TOPO_DOM | Nter | 10 | /note="Virion surface" | |||||||||
TRANSMEM | 11 | 31 | /note="Helical" | |||||||||
TOPO_DOM | 32 | Cter | /note="Intravirion" |
Additional information
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Size range | 93-109 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |