Annotation rule MF_00133
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General rule information [?]

Accession MF_00133
Dates 1-JUN-2001 (Created)
10-OCT-2014 (Last updated, Version 41)
Name Trp_synth_beta
Scope Bacteria
Templates P0A2K1 (TRPB_SALTY); P0A879 (TRPB_ECOLI); Q8U093 (TRPB1_PYRFU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Tryptophan synthase beta chain;
Gene name

Comments [?]

Function The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Catalytic activity L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O.
Cofactor pyridoxal 5'-phosphate
Pathway Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.
Subunit Tetramer of two alpha and two beta chains.
Similarity Belongs to the TrpB family.

Keywords [?]

Gene Ontology [?]

GO:0004834; Molecular function: tryptophan synthase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.

Cross-references [?]

Pfam PF00291; PALP; 1;
TIGRFAMs TIGR00263; TrpB; 1;

Features [?]

From: TRPB_ECOLI (P0A879)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     87     87       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 388-459 amino acids
Related rules None
Fusion None
Comments Highly divergent CHLTR; sequence not included in alignment. Duplicated trpB seems of archaebacterial origin. Some archaea have only such form (AERPE), some have only the classical form (METJA) and some have both including two bacteria (AQUAE and THEMA).