HAMAP rule MF_00207
General rule information
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| Accession | MF_00207 |
| Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 26) |
| Name | PPase_C |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P37487 (PPAC_BACSU); Q58025 (PPAC_METJA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00207 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PPAC |
| Protein name | RecName: Full=Probable manganese-dependent inorganic pyrophosphatase; EC=3.6.1.1; AltName: Full=Pyrophosphate phospho-hydrolase; Short=PPase; |
| Gene name | Name=ppaC; |
Comments
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| CATALYTIC ACTIVITY | Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.; |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the PPase class C family. |
Keywords
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| Cytoplasm | |
| Hydrolase | |
| case <FTGroup:1> | |
| Manganese | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0004427; Molecular function:inorganic diphosphate phosphatase activity |
| GO:0030145; Molecular function:manganese ion binding |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: PPAC_BACSU (P37487) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 9 | 9 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
H | 1 | |||||||
| BINDING | 13 | 13 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | 1 | |||||||
| BINDING | 15 | 15 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | 1 | |||||||
| BINDING | 75 | 75 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | 1 | |||||||
| BINDING | 75 | 75 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | 1 | |||||||
| BINDING | 97 | 97 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
H | 1 | |||||||
| BINDING | 149 | 149 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | 1 | |||||||
Additional information
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| Size range | 307-336 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The sequence of ppaC in THEMA is interrupted by a 130-residue insert that contains 2 CBS domains. |