HAMAP rule MF_00328
General rule information
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| Accession | MF_00328 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 28) |
| Name | Guanylate_kinase |
| Scope(s) |
Bacteria |
| Template(s) | P60546 (KGUA_ECOLI); P15454 (KGUA_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_00328 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KGUA |
| Protein name | RecName: Full=Guanylate kinase; EC=2.7.4.8; AltName: Full=GMP kinase; |
| Gene name | Name=gmk; |
Comments
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| FUNCTION | Essential for recycling GMP and indirectly, cGMP. |
| CATALYTIC ACTIVITY | Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780, ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189, ChEBI:CHEBI:456216; EC=2.7.4.8; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the guanylate kinase family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0004385; Molecular function:guanylate kinase activity |
| GO:0006163; Biological process:purine nucleotide metabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00625; Guanylate_kin; 1; |
| NCBIfam | TIGR03263; guanyl_kin; 1; |
| PROSITE | PS00856; GUANYLATE_KINASE_1; 1; |
| PROSITE | PS50052; GUANYLATE_KINASE_2; 1; |
Features
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| From: KGUA_ECOLI (P60546) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 11 | 18 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GSA]-x-[SAT]-[GA]-x-G-K-x | ||||||||
Additional information
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| Size range | 176-254 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <Unknown> |
| Comments | Possible wrong start in MYCGE and MYCPN |