HAMAP rule MF_00600
General rule information
[?]
| Accession | MF_00600 |
| Dates | 15-NOV-2002 (Created)
28-NOV-2023 (Last updated, Version 77) |
| Name | CH60 |
| Scope(s) |
Bacteria Archaea Methanococcales Methanomicrobiales Methanosarcinaceae Methanospirillaceae Plastid |
| Template(s) | P0A6F5 (CH60_ECOLI); P61491 (CH60_THETH); P31293 (CH60_ALLVI); Q60024 (CH60_THEBR); [ Recover all ] |
| Triggered by |
HAMAP; MF_00600 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | CH60 |
| case not <OG:Chloroplast> | |
| Protein name | RecName: Full=Chaperonin GroEL; EC=5.6.1.7; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin-60; Short=Cpn60; |
| else case <OG:Chloroplast> | |
| Protein name | RecName: Full=Chaperonin GroEL, chloroplastic; EC=5.6.1.7; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin-60; Short=Cpn60; |
| end case | |
| Gene name | Name=groEL; Synonyms=groL; |
Comments
[?]
| FUNCTION | Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano- cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.; EC=5.6.1.7; |
| SUBUNIT | Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES. |
| case <OC:Bacteria> or <OC:Archaea> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the chaperonin (HSP60) family. |
Keywords
[?]
| ATP-binding | |
| Chaperone | |
| case <OC:Bacteria> or <OC:Archaea> | |
| Cytoplasm | |
| end case | |
| Isomerase | |
| Nucleotide-binding | |
Gene Ontology
[?]
| GO:0005524; Molecular function:ATP binding | |
| GO:0051082; Molecular function:unfolded protein binding | |
| GO:0042026; Biological process:protein refolding | |
| case <OCellular component:Bacteria> or <OC:Archaea> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
[?]
| Pfam | PF00118; Cpn60_TCP1; 1; |
| PRINTS | PR00298; CHAPERONIN60; 1; |
| NCBIfam | TIGR02348; GroEL; 1; |
| PROSITE | PS00296; CHAPERONINS_CPN60; 1; |
Features
[?]
| From: CH60_ECOLI (P0A6F5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 30 | 33 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T-x-[GA]-P | ||||||||
| BINDING | 87 | 91 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D-G-T-T-T | ||||||||
| BINDING | 479 | 481 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ND]-[AV]-[AVL] | ||||||||
| BINDING | 51 | 51 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 415 | 415 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| BINDING | 495 | 495 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
Additional information
[?]
| Size range | 470-620 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |