HAMAP rule MF_00967

General rule information [?]

Accession	MF_00967
Dates	25-JUN-2013 (Created) 26-JAN-2023 (Last updated, Version 6)
Name	DEAD_helicase_SrmB
Scope(s)	Bacteria Pseudomonadota
Template(s)	P21507 (SRMB_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00967 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SRMB
RecName: Full=ATP-dependent RNA helicase SrmB;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.13">3.6.4.13</a>;
Gene name	Name=srmB;

Comments [?]

FUNCTION	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
CATALYTIC ACTIVITY	Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
SUBUNIT	Interacts with the 50S ribosomal subunit.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the DEAD box helicase family. SrmB subfamily.

Keywords [?]

ATP-binding
Cytoplasm
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Nucleotide-binding
Ribosome biogenesis

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0003724; Molecular function:RNA helicase activity

GO:0000027; Biological process:ribosomal large subunit assembly

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]