HAMAP logo

HAMAP rule MF_01006

Send feedback

General rule information [?]

Accession MF_01006
Dates 1-MAR-2002 (Created)
29-NOV-2023 (Last updated, Version 59)
Name Undec_diphosphatase
Scope(s) Bacteria
Archaea
Template(s) P60932 (UPPP_ECOLI); P60934 (UPPP_STRPN); [ Recover all ]
Triggered by HAMAP; MF_01006 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UPPP
case <OC:Bacteria>
Protein name RecName: Full=Undecaprenyl-diphosphatase;
                 EC=3.6.1.27;
AltName: Full=Bacitracin resistance protein;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
case <OC:Archaea>
Protein name RecName: Full=Undecaprenyl-diphosphatase;
                 EC=3.6.1.27;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
Gene name Name=uppP;

Comments [?]

case <OC:Bacteria>
FUNCTIONCatalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
end case
case <OC:Archaea>
FUNCTIONCatalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
end case
CATALYTIC ACTIVITY Reaction=di-trans,octa-cis-undecaprenyl diphosphate + H2O = di- trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:28094, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58405, ChEBI:CHEBI:60392; EC=3.6.1.27;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
case <OC:Bacteria>
MISCELLANEOUSBacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
end case
SIMILARITYBelongs to the UppP family.

Keywords [?]

case <OC:Bacteria>
Antibiotic resistance
Cell shape
Cell wall biogenesis/degradation
end case
Hydrolase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <OC:Bacteria>
Peptidoglycan synthesis
end case
Cell membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0050380; Molecular function:undecaprenyl-diphosphatase activity
case <OCellular component:Bacteria>
GO:0046677; Biological process:response to antibiotic
end case
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02673; BacA; 1;
NCBIfam TIGR00753; Undec_PP_bacA; 1;
General Transmembrane; -; 5-9;

Features [?]


Additional information [?]

Size range 237-343 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments UPPP2 from RHILO is shorter but can not easily be extended.



View rule in raw text format (no links)