HAMAP rule MF_01022
General rule information
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Accession | MF_01022 |
Dates | 14-JUN-2002 (Created)
1-JUN-2023 (Last updated, Version 32) |
Name | Bifunc_HisB |
Scope(s) |
Bacteria |
Template(s) | Q9S5G5 (HIS7_ECO57); P06987 (HIS7_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01022 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | HIS7 |
Protein name | RecName: Full=Histidine biosynthesis bifunctional protein HisB; Includes: RecName: Full=Histidinol-phosphatase; EC=3.1.3.15; Includes: RecName: Full=Imidazoleglycerol-phosphate dehydratase; Short=IGPD; EC=4.2.1.19; |
Gene name | Name=hisB; |
Comments
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CATALYTIC ACTIVITY | Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol- 4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040, ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19; |
CATALYTIC ACTIVITY | Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate; Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
case <FTGroup:1> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; |
end case | |
PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. |
PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | In the N-terminal section; belongs to the histidinol- phosphatase family. |
SIMILARITY | In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. |
Keywords
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Amino-acid biosynthesis | |
Cytoplasm | |
Histidine biosynthesis | |
Hydrolase | |
Lyase | |
Magnesium | |
Metal-binding | |
Multifunctional enzyme | |
case <FTGroup:1> | |
Zinc | |
end case |
Gene Ontology
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GO:0004401; Molecular function:histidinol-phosphatase activity |
GO:0004424; Molecular function:imidazoleglycerol-phosphate dehydratase activity |
GO:0000105; Biological process:histidine biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00475; IGPD; 1; |
Pfam | PF08645; PNK3P; 1; |
NCBIfam | TIGR01662; HAD-SF-IIIA; 1; |
NCBIfam | TIGR01261; HisB_Nterm; 1; |
NCBIfam | TIGR01656; Histidinol-ppas; 1; |
PROSITE | PS00954; IGP_DEHYDRATASE_1; 1; |
PROSITE | PS00955; IGP_DEHYDRATASE_2; 1; |
Features
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From: HIS7_ECO57 (Q9S5G5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | Nter | 166 | /note="Histidinol-phosphatase" | |||||||||
REGION | 167 | Cter | /note="Imidazoleglycerol-phosphate dehydratase" | |||||||||
ACT_SITE | 9 | 9 | /note="Nucleophile" | D | ||||||||
ACT_SITE | 11 | 11 | /note="Proton donor" | D | ||||||||
BINDING | 9 | 9 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
BINDING | 11 | 11 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
BINDING | 93 | 93 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 95 | 95 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
BINDING | 101 | 101 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 103 | 103 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 130 | 130 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D |
Additional information
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Size range | 350-390 amino acids |
Related rules |
MF_00076 |
Fusion | Nter: None Cter: None |