HAMAP rule MF_01242
General rule information
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| Accession | MF_01242 |
| Dates | 23-MAY-2003 (Created)
19-NOV-2019 (Last updated, Version 18) |
| Name | Aliphatic_amidase |
| Scope(s) |
Bacteria |
| Template(s) | Q9L543 (AMIE_BACSP); Q9RQ17 (AMIE_GEOSE); O25067 (AMIE_HELPY); P11436 (AMIE_PSEAE); Q01360 (AMIE_RHOER); [ Recover all ] |
| Triggered by |
HAMAP; MF_01242 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AMIE |
| Protein name | RecName: Full=Aliphatic amidase; EC=3.5.1.4; AltName: Full=Acylamide amidohydrolase; |
| Gene name | Name=amiE; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. |
| FUNCTION | Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates. |
| CATALYTIC ACTIVITY | Reaction=a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+); Xref=Rhea:RHEA:12020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:35757, ChEBI:CHEBI:83628; EC=3.5.1.4; |
| SIMILARITY | Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family. |
Keywords
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Gene Ontology
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| GO:0004040; Molecular function:amidase activity |
Cross-references
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Features
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| From: AMIE_PSEAE (P11436) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 59 | 59 | /note="Proton acceptor" | E | ||||||||
| ACT_SITE | 134 | 134 | /note="Proton donor" | K | ||||||||
| ACT_SITE | 166 | 166 | /note="Nucleophile" | C | ||||||||
Additional information
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| Size range | 339-348 amino acids |
| Related rules |
MF_01243 |
| Fusion | Nter: None Cter: None |