HAMAP rule MF_01247
General rule information
[?]
| Accession | MF_01247 |
| Dates | 6-APR-2004 (Created)
19-NOV-2022 (Last updated, Version 25) |
| Name | HTH_type_MalT |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P06993 (MALT_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01247 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | MALT |
| Protein name | RecName: Full=HTH-type transcriptional regulator MalT; AltName: Full=ATP-dependent transcriptional activator MalT; |
| Gene name | Name=malT; |
Comments
[?]
| FUNCTION | Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. |
| ACTIVITY REGULATION | Activated by ATP and maltotriose, which are both required for DNA binding. |
| SUBUNIT | Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose. |
| SIMILARITY | Belongs to the MalT family. |
Keywords
[?]
| DNA-binding |
| Transcription |
| Transcription regulation |
| Activator |
| ATP-binding |
| Nucleotide-binding |
| Carbohydrate metabolism |
Gene Ontology
[?]
| GO:0005524; Molecular function:ATP binding |
| GO:0003700; Molecular function:DNA-binding transcription factor activity |
| GO:0045913; Biological process:positive regulation of carbohydrate metabolic process |
| GO:0045893; Biological process:positive regulation of DNA-templated transcription |
Cross-references
[?]
| Pfam | PF00196; GerE; 1; |
| PRINTS | PR00038; HTHLUXR; 1; |
| PROSITE | PS00622; HTH_LUXR_1; 1; |
| PROSITE | PS50043; HTH_LUXR_2; 1; |
Features
[?]
| From: MALT_ECOLI (P06993) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 39 | 46 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
x-P-[AS]-G-[YF]-G-K-[TS] | ||||||||
Additional information
[?]
| Size range | 870-940 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |