HAMAP rule MF_01395

General rule information [?]

Accession	MF_01395
Dates	27-NOV-2008 (Created) 1-JUN-2023 (Last updated, Version 24)
Name	AcetylCoA_CT_beta
Scope(s)	Bacteria Plastid
Template(s)	P0A9Q5 (ACCD_ECOLI); Q5HF73 (ACCD_STAAC); Q2MI91 (ACCD_SOLLC); P18823 (ACCD_PEA); [ Recover all ]
Triggered by	HAMAP; MF_01395 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ACCD
case <OG:Chloroplast>
Protein name	RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic; Short=ACCase subunit beta; Short=Acetyl-CoA carboxylase carboxyltransferase subunit beta; EC=2.1.3.15;
Gene name	Name=accD;
else
Protein name	RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Short=ACCase subunit beta; Short=Acetyl-CoA carboxylase carboxyltransferase subunit beta; EC=2.1.3.15;
Gene name	Name=accD;
end case

Comments [?]

FUNCTION	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
CATALYTIC ACTIVITY	Reaction=acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl- CoA + N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54728, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145; EC=2.1.3.15;
case <FTGroup:1>
COFACTOR	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
PATHWAY	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
case <OG:Chloroplast>
SUBUNIT	Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).
else
SUBUNIT	Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
end case
case <OC:Bacteria>
SUBCELLULAR LOCATION	Cytoplasm.
else case <OG:Chloroplast>
SUBCELLULAR LOCATION	Plastid, chloroplast stroma.
end case
SIMILARITY	Belongs to the AccD/PCCB family.

Keywords [?]

Gene Ontology [?]

GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity
GO:0006633; Biological process:fatty acid biosynthetic process
case <OCellular component:Bacteria>
GO:0005737; Cellular component:cytoplasm
else case <OG:Chloroplast>
GO:0009570; Cellular component:chloroplast stroma
end case
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Features [?]

From: ACCD_ECOLI (P0A9Q5)

Key

From

Description

Tag

Condition

FTGroup

case not <OC:Mycobacterium>

ZN_FING

/note="C4-type"

C-x(1,2)-C-x(12,18)-C-x(1,2)-C

BINDING

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"

BINDING

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"

BINDING

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"

BINDING

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"

end case

Additional information [?]

Size range	288-700 amino acids
Related rules	None
Fusion	Nter: None Cter: MF_00823 (accA)
Comments	A few Bacillota encode a fusion between AccD and AccA (CLOTE, EUBR3, FRAAA, FRACC, FRASN, NATTJ) as do a few Actinomycetota (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations and an occasional fragment of the other form which may or may not be expressed (see rice). The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes. Not all proteins are able to bind the zinc. Mycobacteria do not seem to have this particular protein; they have 6 accD paralogues however.