HAMAP rule MF_01570

General rule information [?]

Accession	MF_01570
Dates	21-AUG-2006 (Created) 1-JUN-2023 (Last updated, Version 13)
Name	Pro_tRNA_synth_type2
Scope(s)	Bacteria Alphaproteobacteria Epsilonproteobacteria
Template(s)	Q6N5P6 (SYP_RHOPA); [ Recover all ]
Triggered by	HAMAP; MF_01570 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SYP
Protein name	RecName: Full=Proline--tRNA ligase; EC=6.1.1.15; AltName: Full=Prolyl-tRNA synthetase; Short=ProRS;
Gene name	Name=proS;

Comments [?]

FUNCTION	Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
CATALYTIC ACTIVITY	Reaction=ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl- tRNA(Pro); Xref=Rhea:RHEA:14305, Rhea:RHEA-COMP:9700, Rhea:RHEA- COMP:9702, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:60039, ChEBI:CHEBI:78442, ChEBI:CHEBI:78532, ChEBI:CHEBI:456215; EC=6.1.1.15;
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0004827; Molecular function:proline-tRNA ligase activity

GO:0006433; Biological process:prolyl-tRNA aminoacylation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]