HAMAP rule MF_01601
General rule information
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Accession | MF_01601 |
Dates | 25-OCT-2004 (Created)
1-JUN-2023 (Last updated, Version 27) |
Name | Heptose_epimerase |
Scope(s) |
Bacteria |
Template(s) | P67910 (HLDD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01601 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | HLDD |
Protein name | RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase; EC=5.1.3.20; AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase; Short=ADP-glyceromanno-heptose 6-epimerase; Short=ADP-hep 6-epimerase; Short=AGME; |
Gene name | Name=hldD; |
Comments
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FUNCTION | Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. |
CATALYTIC ACTIVITY | Reaction=ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D- manno-heptose; Xref=Rhea:RHEA:17577, ChEBI:CHEBI:59967, ChEBI:CHEBI:61506; EC=5.1.3.20; |
COFACTOR | Name=NADP(+); Xref=ChEBI:CHEBI:58349; Note=Binds 1 NADP(+) per subunit.; |
PATHWAY | Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno- heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D- glycero-beta-D-manno-heptose 7-phosphate: step 4/4. |
SUBUNIT | Homopentamer. |
DOMAIN | Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain. |
SIMILARITY | Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. |
Keywords
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case <FT:18> | |
Acetylation | |
end case | |
Carbohydrate metabolism | |
Isomerase | |
NADP |
Gene Ontology
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GO:0008712; Molecular function:ADP-glyceromanno-heptose 6-epimerase activity |
GO:0005975; Biological process:carbohydrate metabolic process |
Cross-references
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Features
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From: HLDD_ECOLI (P67910) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 10 | 11 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
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BINDING | 31 | 32 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
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BINDING | 75 | 79 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
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BINDING | 201 | 204 | /ligand="substrate" | |||||||||
ACT_SITE | 140 | 140 | /note="Proton acceptor" | Y | ||||||||
ACT_SITE | 178 | 178 | /note="Proton acceptor" | K | ||||||||
BINDING | 38 | 38 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[KQR] | ||||||||
BINDING | 53 | 53 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[KQR] | ||||||||
BINDING | 92 | 92 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
N | ||||||||
BINDING | 144 | 144 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
K | ||||||||
BINDING | 169 | 169 | /ligand="substrate" | N | ||||||||
BINDING | 170 | 170 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[VI] | ||||||||
BINDING | 178 | 178 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
K | ||||||||
BINDING | 180 | 180 | /ligand="substrate" | x | ||||||||
BINDING | 187 | 187 | /ligand="substrate" | [HKQ] | ||||||||
BINDING | 209 | 209 | /ligand="substrate" | [HR] | ||||||||
BINDING | 272 | 272 | /ligand="substrate" | Y | ||||||||
case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
MOD_RES | 267 | 267 | /note="N6-acetyllysine" | K | ||||||||
end case |
Additional information
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Size range | 291-340 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |